Brian L. Pagenkopf

Brian L. Pagenkopf

Contact Information

Title: Professor
Office: 2020 BGS
Lab: 2008 BGS
Phone (Office): ext 81430
Phone (Lab): ext 81589

Organic Teaching Division

Synthesis, Catalysis and Molecular Materials

Synthetic methods and natural product total synthesis, catalysis, silole-based materials

Group Website 
LinkedIn, Google Scholar, ResearchGate


B.Sc., University of Minnesota; Ph.D., Montana State University; Postdoc, Caltech and ETH


  • College of Natural Sciences Teaching Excellence Award
  • Department of Defense New Investigator Award
  • NSERC Discovery Accelerator Supplement


In my group we are engaged in a variety of reaction discovery, methodology development and natural products/functional materials synthesis projects. Our long term objectives for new transformations is to bring them to a sufficient state of maturity that they find use in the standard repertoire of synthetic chemistry. We use natural products to contextualize representative substrates to ensure synthetic relevancy, and in turn some of these become targets for total synthesis. We have a multidisciplinary research program with expertise in cyclopropanes, epoxide reactions, THF synthesis, asymmetric catalysis and siloles.


  • 2213 - Organic Chemistry for Life Sciences
  • 2223 - Organic Chemistry of Biological Molecules
  • 2283 - Organic Chemistry II: Mechanism and Reactivity
  • 3330 - Industrial Chemistry
  • 3370 - Organic and Inorganic Structure Elucidation
  • 3373 - Organic Chemistry III: Reactions and Strategies for Synthesis
  • 4473 - Modern Chemical Synthesis
  • 9563 - Organic Synthesis
  • 9623 - Advanced Synthetic Methods
  • 9723 - Advanced Synthetic Methods II


  • Correlating Structures to Electrochemiluminescence Efficiencies of Silole Compounds in Coreactant Systems. Xiaoli Qin, Liuqing Yang, Xin Wang, Darshil Patel, Kenneth Chu, Lindsay Kelland, Jonathan Ralph Adsetts, Congyang Zhang, Mark Steven Workentin, Brian L. Pagenkopf and Zhifeng Ding, ChemElectroChem 20229, e202200605. 

  • Benzosiloles with Crystallization‐induced Emission Enhancement of Electrochemiluminescence: Synthesis, Electrochemistry, and Crystallography. Liuqing Yang, Donghyun Koo, Jackie Wu, Jonathan M. Wong, Tyler Day, Ruizhong Zhang, Harshana Kolongoda, Kehan Liu, Jian Wang, Zhifeng Ding, Brian L. Pagenkopf, Chemistry—A European Journal 202026, 11715 - 11721. 

  • Synthesis of Hexahydropyridazines by [4+2] Cycloaddition of Donor-Acceptor Cyclobutanes and cis-Diazenes. Jackie Wu, Paul Winiarz, Dhwanish Patel, Johanna de Jong, David Tong, Tristan Chidley, Naresh Vemula and Brian L. Pagenkopf, Organic Letters 2020, 22, 3140–3144. 

  • Gram Scale Synthesis of the Co(nmp)Catalyst to Prepare trans-2,5-Disubstituted Tetrahydrofurans by the Aerobic Oxidative Cyclization of 4-Pentene-1-ols. Barbora Morra, Nicholas A. Morra, Daniel G. MacDonald and Brian L. Pagenkopf, Synthesis 2020, 52, 847–852.

  • Synthesis of Functionalized Tetrahydropyridines by SnCl4-mediated [4+2] Cycloaddition between Donor–Acceptor Cyclobutanes and Nitriles. David Tong, Jackie Wu, Nathan Bazinski, Donghyun Koo, Naresh Vemula and Brian L. Pagenkopf, Chemistry—A European Journal 2019, 25, 15244–15247.