PTG - Pre-Clinical

The Pre-Clinical PTG conducts studies to:

  1. Screen for biological and pharmacological activities in vitro and in vivo for relative potency (EC50, IC50 values)
  2. Elucidate mechanism(s) of action to provide biological plausibility of evidence
  3. Conduct clinical studies in selected cases for validation of results obtained from pre-clinical studies
  4. Pharmacokinetics in animals and humans

For a list of recent publications, click here.

Pre-Clinical PTG Members


Dr. Edmund Lui - UWO, Dept. Physiology & Pharmacology

Keywords: vascular protection, anti-inflammatory, anti-oxident

Not currently accepting students or post-doctoral fellows


Dr. Marica Bakovic - University of Guelph, Dept. Human Health & Nutritional Sciences

Keywords: metabolism, metabolic syndrome, obesity, diabetes


Dr. James Henry - McMaster University, Dept. Psychiatry & Behavioural Neurosciences

Keywords: pain, fatigue, osteoarthritis


Dr. Zach Suntres - Northern Ontario School of Medicine, Division of Medical Sciences

Keywords: nanotechnology-drug delivery systems, liver and lung injuries, neuronal/oxidative stress mechanisms, biomarkers


Dr. Qingping Feng - UWO, Dept. Physiology and Pharmacology

Keywords: myocardial ischemia and reperfusion, cardioprotection, nitric oxide, signal transduction, apoptosis, cardiomyocyte culture


Dr. Morris Karmazyn - UWO, Dept. Physiology and Pharmacology.

Keywords: hypertrophy, cardiac myocytes, phenylephrine, cell signalling, calcineurin activation, Na-H exchange


Dr. Earl Noble - UWO, Dept. Kinesiology

Keywords: exercise, stress, endurance


Dr. Subrata Chakrabarti - UWO, Dept. Pathology

Keywords: chronic diabetic complications, diabetic retinopathy, diabetic cardiomyopathy, vasoactive factors, extracellular matrix proteins, angiogenesis, epigenetics


Dr. John Trevithick - UWO, Depts. Kinesiology, Biochemistry

Keywords: retinopathy, cataracts


Dr. Lique Coolen - UWO, Dept. Physiology and Pharmacology

Keywords: erectile dysfunction, sexual motivation, sexual arousal, Zucker rat, ex copula


Dr. Joaquim Madrenas - Robarts Research Institute; UWO, Dept. MIcrobiology & Immunology

Keywords: T-lymphocyte activation, adaptive immunity, infectious disease, allergies, cancer


Dr. Kem Rogers -UWO, Dept. Anatomy & Cell Biology

Keywords: vascular biology, atherosclerosis, aortic valve sclerosis


Dr. John Ciriello - UWO, Dept. Physiology and Pharmacology

Keywords: sleep apnea, hypertension, arterial pressure, cardiac funcion