Selected Recent Publications Related to the Research Area 3
(Human Placenta as a Model for Tumor Progression):

Khoo, N.K.S., Bechberger, J.F., Shepherd, T., Bond, S.L., McCrae, K., Hamilton, G.S. and Lala, P.K.  SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype: Mechanisms responsible for hyperinvasiveness and resistance to antiinvasive action of TGFb.  Intl. J. Cancer.  77, 429-439, 1998.

Khoo, N.K.S., Zhang, Y., Bechberger, J.F., Bond, S.L., Hum, K. and Lala, P.K.  SV40 Tag transformation of the normal invasive trophoblast results in a premalignant phenotype: II.  Changes in gap junctional intecellular communication.  Intl. J. Cancer.  77, 440-448, 1998.

Lala, P.K., Khoo, N.K.S., Guimond, M.J. and Chakraborty, C.  Control mechanisms in human trophoblast proliferation and invasiveness and their derangement during trophoblastic tumor progression.  Trophoblast Res. 13, 119-136, 1999.

Lee, B.P., Rushlow, W., Chakraborty, C., and Lala, P.K. Human trophoblast as a model for tumor progression: Differential gene expression in premalignant human trophoblast. Role of IGFBP-5. Int. J. Cancer. 94, 674-684, 2001.

Xu, G., Chakraborty, C. and Lala, P.K. Expression of TGF-b signaling genes in the normal, premalignant and malignant human trophoblast: loss of smad3 in choriocarcinoma cells. Biochem. Biophys. Res. Comm. 287, 47-55, 2001.

Lala, P.K., Lee BP, Xu G and Chakraborty, C., Human placental trophoblast as a model for tumour progression. Can. J. Physiol. Pharmacol. 80, 142-149, 2002.

Xu G, Chakraborty C and Lala PK.  Restoration of TGF-beta regulation of plasminogen activator inhibitor-1 in Smad3-restituted human choriocarcinoma cells.  Biochem Biophys Res Commun. 294, 1079-86, 2002.

Xu, G., Chakraborty, C. andLala, P. K. Reconstitution of Smad3 restores TGF-b response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells. Biochem Biophys Res Commun. 300, 383-390, 2003.

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