Selected Recent Publications Related to the Research Area 2
(Mechanism in breast cancer progression and metastasis):

Jadeski, L.C., Chakraborty C., and Lala, P. K. Nitric Oxide-mediated promotion of mammary tumor cell migration requires seqented activation of Nitric Oxide synthase, guanylate cyclase and MAP Kinase. Int. J. Cancer. 106, 496-504. 2003.

Timoshenko, A.V., Xu, G., Chakrabarti, S., Lala, P.K., and Chakraborty, C. Role of postaglandin E2 receptors in migration of murine and human breast cancer cells. Exp Cell Res. 289(2), 265-74, 2003.

Timoshenko, A. V., Lala, P. K., Chakraborty, C. PGE2-mediated up-regulation of iNOS in murine breast cancer cells through the activation of EP4 receptors. Int. J. Cancer, 108, 384-389, 2004.

Timoshenko,A.V., Chakraborty C., Wagner G.F., and Lala, P.K. COX-2-mediated upregulation of the lymphangiogenic factor VEGF-C in human breast cancer. Brit. J. Cancer, 94 (8) 1154-63, 2006.

Timoshenko, A.V., Rastogi,S. and Lala, P.K. Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells. Brit. J. Cancer 97 (10), 1090-1098, 2007.

Bhattacharjee, R.N, Timoshenko, A, Cai, J and Lala, P.K. Relationship between Cyclo-oxygenase-2 and Human Epidermal Growth fector Receptor-2 in Vascular Endothelial Growth Factor-C upregulation and lymphangiogenesis in human breast cancer. Cancer Science, 101 (9) 2016-2032, Sept 2010, epub. July1, 2010.

Timoshenko A.V, Kaltner H, André S, Gabius H-J and Lala P K. Differential stimulation of VEGF-C production by adhesion/growth-regulatory galectins and plant lectins in human breast cancer cells. Anticancer research, 30, 4829-4834, 2010.

Majumder M, Tutunea-Fatan1 E, Xin X, Rodriguez-Torre M, Torres-Garcia J , Wiebe1 R,. Timoshenko AV, Bhattacharjee RN, Chambers AF , Lala, PK Co-expression of ?9?1 integrin and VEGF-D confers lymphatic metastatic phenotype to a human breast cancer cell line MDA-MB-468LN. PLoS One 2012 7(4): e35094. doi:10.1371/journal.pone.0035094

Xin X, Majumder M, Girish G, Mohindra V, Maruyama T and Lala P.K Targeting COX-2 and EP4 to Control Tumor Growth, Angiogenesis, Lymphangiogenesis and Metastasis to the Lungs and Lymph Nodes in a Mouse Breast Cancer Model. Lab Investigation (2012) 92, 1115–1128;doi:10.1038/labinvest.2012.90; published online 28 May 2012.

Majumder, M, Xin X and Lala P K. A practical and sensitive method of quantitating lymphangiogenesis in vivo. Lab Invest. 2013 May 27. doi: 10.1038/labinvest.2013.72. [Epub ahead of print]

Majumder M, Xin X, Liu L, Girish GV and Lala PK. Prostaglandin E2 receptor EP4 as the common target on cancer cells and macrophages to abolish angiogenesis, lymphangiogenesis, metastasis, and stem-like cell functions. Cancer Science 105 (2014) 1142–1151.

Tutunea-Fatan Elena, Majumder, Mousumi Xin, Xiping and Lala Peeyush K, The Role of CCL21/CCR7 Chemokine Axis in Breast Cancer Induced Lymphangiogenesis. Molecular Cancer (2015) 14:35 DO10.1186/s12943-015-0306-4.

Majumder M, Landman E, Liu L, Hess D and Lala P.K. COX2 Elevates Oncogenic miR526bin Breast Cancer by EP4 Activation. Molecular Cancer Research (2015) 13(6) 1022-1033, Published Online March 2, 2015; doi: 10.1158/1541-7786.MCR-14-0543

15. Majumder M, Xin X, Liu L, Tutunea-Fatan E, Rodriguez-Torres M, Vincent K, Postovit L-M, Hess D, andLala PK, COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis. Stem cells. 34:2290–2305(2016)

Nandi P, Girish GV, Majumder M, Xin X, Tutunea-Fatan E and Lala, PK.PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells.(2017) BMC Cancer, 017 Jan 5;17(1):11. doi: 10.1186/s12885-016-3018-2.PMID: 28056899

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