Selected Recent Publications Related to the Research Area 1
(Mechanisms at the fetal-maternal interface regulating placental development and functions):

Xu, G., Chakraborty, C. and Lala, P. K. Reconstitution of Smad3 restores TGF-? response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells. Biochem Biophys Res Commun. 300, 383-390, 2003.

Liu, J., Chakraborty, C., Barbin Y.P., Dixon S.J. and Lala P.K. Non catalytic domain of uPA stimulates human extravillous trophoblast migration by utilising phospholipase C, P-I-3 kinase and MAP kinase, Exp. Cell Res. 286, 138-151, 2003.

Chakraborty, C., Barbin Y.P., Dixon, S.J., Chakraborty, S., Chidiac P. and Lala, P.K. Endothelin-1 promotes migration, elevation of [Ca++]i and phosphorylation of MAP kinase in a human extravillous trophoblast cell line. Mol. Cell Endcrinol. 201, 63-73, 2003.

Lala, P.K. and Chakraborty C. Factors regulating trophoblast migration and invasiveness: Possible derangements contributing to preeclampsia and fetal injury (current topic). Placenta, 24 (6) 575-587, 2003, 2003.

Munir, S, Xu, G., Wu, Y., Yang, B., Lala P.K. and Peng C. Nodal and activin receptor-like kinase (ALK) 7 inhibits proliferation and induce apoptosis in human trophoblast cells. J Biol Chem. 279 (30) 31277-31286, 2004.

Nicola C., Timoshenko A.V., Dixon J., Lala P.K. and Chakraborty C. EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain. J Clin Endocrinol Metab. 90(8), 4736-46, 2005.

Zygmunt, M., McKinnon, T., Heer F., Lala, P.K. and Han, V.K.M. HCG increases trophoblast migration in vitro via the insulin-like growth factor-II/mannose-6 phosphate receptor. Mol Hum Reprod. 11(4):261-7. 2005.

Nicola, C., Chirpac,A., Lala, P.K. and Chakraborty,C Roles of Rho guanosine triphosphatase A, Rho kinases and extracellular signal regulated kinases (1/2) in Prostaglandin E2-mediated migration of first trimester human extravillous trophoblast. Endocrinology. Epub 13 December, 2007, 149(3) 1243-51, 2008.

Nicola, C., Lala, P.K. and Chakraborty, C. Prostaglandin(PG)E2-mediated migration of human trophoblast requires Rac1 and Cdc42 GTPases.Biol. Reprod 78, 976-982,2008.

Ajayai, F., Congosa, N., Gaffey, T., Asman, Y.W., Watson, W., Baldi, A., Lala, P.K., Shridhar, V., Brost, B. and Chien, J. Elevated expression of serine protease HtrA1 inn preeclampsia and its role in trophoblast migration and invasion Amer J Obstet. Gynecol. 199, issue 5, 557.e1-557.e10, November 2008.

Iacob D., Cai J., Tsonis M., Babwah A., Chakraborty C., Bhattacharjee R.N. and Lala, P.K. Decorin-mediated inhibition of proliferation and migration of the human trophoblast via different tyrosine kinase receptors. Endocrinology 149(12) 6187-97, E pub August 14, 2008.

Khan, G.A., Gannareddy, G., Lala, N , DiGugliemo, J and Lala, P.K. Decorin is a novel VEGFR-2 binding antagonist for human extravillous trophoblast Molecular Endocrinology, E pub June 9, 2011; 25(8): 1431-1443.

Lala N, Girish G V, Cloutier-Bosworth A and Lala P K. Mechanisms in Decorin regulation of Vascular Endothelial Growth Factor-induced Human Trophoblast Migration and Acquisition of Endothelial Phenotype. BIOLOGY OF REPRODUCTION (2012) 87(3):59, 1–14 ; before print June 13, 2012, doi: 10.1095/biolreprod.111.097881

Lala, P.K. and Nandi, P. (2016) Mechanisms of trophoblast migration, endometrial angiogenesis in preeclampsia: the role of decorin. (Invited and commissioned review).CELL ADHESION & MIGRATION. VOL. 10, NOS. 1–2, 1–15. Published on line; http://dx.doi.org/10.1080/19336918.2015.1106669

Nandi P, Siddiqui MF and Lala PK (2015) Restraint of trophoblast invasion of the uterus by decorin : role in preeclampsia. American J. Reprod. Immunol. doi:10.1111/aji.12449, 2015

206 Siddiqui MF. Nandi P, Girish GV, Nygard K, Eastabrook G, de Vrijer B, Han VKM, Lala PK, (2016) Decorin over-expression by decidual cells in preeclampsia: a potential blood biomarker. American J Obstet Gynecol 215:361.e1-15. http://dx.doi.org/10.1016/j.ajog.2016.03.020

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