Index to Platforms:

Plant Biotechnology

  1. Sun, C., Li, Y., Wu, Q., Luo, H., Sun, Y., Song, J., Lui, E.M.K and Chen, S. (2010 04) De novo sequencing and analysis of the American ginseng root transcriptome using a GS FLX Titanium platform to discover putative genes involved in ginsenoside biosynthesis. BMC Genomics, 11:262. Article
  2. Lui, E.M.K., Brown, D.C.W. (2010 09) New Technologies for Ginseng Agriculture and Product Development: Perspective of the Ontario Ginseng Innovation and Research Consortium. The Korean Society of Ginseng. 
  3. Uchendu, E.E., Paliyath, G., Brown, D.C.W., Saxena, P.K. (2011 05) In vitro propagation of North American ginseng (Panax quinquefolius L.). In Vitro Cell.Dev.Biol.—Plant DOI 10.1007/s11627-011-9379-y.  Article
  4. Uchendu, E.E., Shukla, M.R., Reed, B.M., Brown, D.C.W and Saxena, P.K. (2011 08) Improvement of Ginseng by In Vitro Culture: Challenges and Opportunities. COMPREHENSIVE BIOTECHNOLOGY, Murray Moo-Young 2nd edition 4.25, Elsevier. The Netherlands. Article
  5. Uchendu, E.E.; Brown, D.C.W. and Saxena P.K. (2011 11) Cryopreservation of Shoot Tips and Cotyledons of The North American Ginseng (Panax quinquefolius L.). Cryo Letters. 2011 Nov-Dec;32(6):463-472. Article
  6. Lemmon, H.R., Sham, J., Chau, L.A., Madrenas, J. (2012) High molecular weight polysaccharides are key immunomodulators in North American ginseng extracts: characterization of the ginseng genetic signature in primary human immune cells. Journal of Ethnopharmacology (2012), Article
  7. J. Yuk, K.L. McIntyre, C. Fische, J. Hicks, K.L. Colson, E. Lui, D. Brown, J.T. Arnason. 2012. Distinguishing Ontario ginseng landraces and ginseng species using NMR-based Metabolomics. Analytical and Bioanalytical Chemistry (e-published Dec. 2012)


  1. McIntyre, K.L., Luu, A., Sun, C., Brown, D., Lui, E.M.K., Arnason, J.T. (2010 10) Ginsenoside VariationWithin and Between Ontario Ginseng Landraces: Relating Phytochemistry to Biological Activity. Recent Advances in Phytochemistry 41: 97-107 2011 Article
  2. Luu, A., Foster, B.C., McIntyre, K.L., Tam, T.W. and Arnason, J.T.(2010 10) Pharmacogenetics in Potential Herb–Drug Interactions: Effects of Ginseng on CYP3A4 and CYP2C9 Allelic Variants. Recent Advances in Phytochemistry 41: 59-66. 2011. Article
  3. Lui, E.M.K., Azike, C.G., Guerrero, A.J., Rome, A.A., Pei H., Arnason, J.T., Charpentier, P.A. (2012)Bioactive Polysaccharides of Panax quinquefolius in modulation of immune function: phytochemical and pharmacological characterization. "Polysaccharides", ISBN 980-953-307-162-1.
  4. Edmund M. K. Lui, Chike G. Azike, José A. Guerrero-Analco, Ahmad A. Romeh, Hua Pei, Sherif J. Kaldas, John T. Arnason and Paul A. Charpentier,   Bioactive Polysaccharides of American Ginseng Panax quinquefolius L. in Modulation of Immune Function: Phytochemical and Pharmacological Characterization,   The Complex World of Polysaccharides (ISBN 978-953-51-0819-1), InTech, 2012, Chapter 19, pages 513-534



  1. Toth, J.M., Hewson, G.L., Frodermann, V., Chau, L.A., Azike, C., Lui, E.M.K., Madrenas, J. (2010 09) Modulatory Effects of Ginseng Extracts on Human Innate and Adaptive Immune Responses. The Korean Society of Ginseng
  2. Guo, J., Gan, X.T., Haist, J.V., Rajapurohitam, V., Zeidan, A., Faruq, N.S., Karmazyn, M.(2010 10)Ginseng Inhibits Cardiomyocyte Hyupertrophy and Heart Failure via NHE-1 Inhibition and Attenuation of Calcineurin Activation. Circulation: Heart Failure. 2011; 4: 79-88. Article
  3. Trevithick, J.R., Dzialoszynski, T.D. and Noble, E.G. (2011) Ontario ginseng extracts protect against cataract and oxidative stress in pig lenses exposed to high energy proton and neutron irradiation. Invest Ophthalmol Vis Sci 52: E-Abstract 1550, 2011.
  4. Migchels, M.J., Iqbal, W., Moreau, J.M., Ciriello, J. (2011 03) Ingestion of North American Ginseng Decreases Circulating Levels of Leptin and Insulin. FASEB J March 17, 2011 25:853.8. Article
  5. Azike, C.G., Charpentier, P.A., Hou, J., Pei, H., Lui, E.M.K. (2011 05) The Yin and Yang actions of North American ginseng root in modulating the immune function of macrophage. Chinese Medicine 2011,6:21 doi:10.1186/1749-8546-6-21. 27 May 2011. Article
  6. Alipour, M., Omri, A., Suntres, Z.E. (2011 06) Ginseng aqueous extract attenuates the production of virulence factors, stimulates twitching and adhesion, and eradicates biofilms of Pseudomonas aeruginosa. Canadian Journal of Physiology and Pharmacology, 2011, 89:(6) 419-427, 10.1139/y11-057 Article
  7. Carruthers, Colin P., The influence of North American ginseng on the initiation and progression of atherosclerosis Article
  8. Barnes, Matthew J., Effects of North American ginseng on sexual behavior in male rats Article
  9. Moey, M., Rajapurohitam, V., Zeidan, A., Karmazyn, M. (2011 08) Ginseng (Panax quinquefolius) attenuates leptin-induced cardiac hypertrophy through inhibition of p115RhoGEF-RhoA/ROCK-dependent MAPK pathway activation.. J Pharmacol Exp Ther 339: 746-56, 2011 jpet.111.182600. Article
  10. Sen, S., Chen, S., Feng, B., Wu, Y., Lui, E.M.K., Chakrabarti, S. (2011 08) American ginseng (Panax quinquefolius) prevents glucose-induced oxidative stress and associated endothelial abnormalities. Phytomedicine. 2011 Oct 15;18(13):1110-7. Epub 2011 Aug 16. Article
  11. Estaki, M. and E.G. Noble (2011 09) North American ginseng supplementation reduces skeletal muscle damage induced by acute eccentric exercise. Applied Physiology, Nutrition and Metabolism. 36: S2, S315, 2011.
  12. Dableh LJ, Yashpal K, Henry JL.  Neuropathic pain as a process: reversal of chronification in an animal model.  J Pain Res. 2011;4:315-23. Epub 2011 Sep 29. Article
  13. Wu, Y., Lu, X., Xiang, F.-L., Lui, E.M.K. and Feng, Q. (2011 09) North American ginseng protects the heart from ischemia and reperfusion injury via upregulation of endothelial nitric oxide synthase. Volume 64, Issue 3, September 2011, Pages 195-202. Article
  14. Karmazyn, M., Moey, M., Gan, X.T. (2011 10) Therapeutic potential of ginseng in the management of cardiovascular disorders. Drugs: 22 October 2011 - Volume 71 - Issue 15 - pp 1989-2008 doi: 10.2165/11594300-000000000-00000. Article
  15. Moey, Melissa Y.Y., Studies into the mechanisms underlying the cardiac anti-hypertrophic and anti-remodelling effects of ginseng Article
  16. Estaki, Mehrbod, Protective role of alcohol and aqueous extracts of North American ginseng against eccentric exercise-induced muscular damage Article
  17. Sen, S., Chen, S., Feng, B., Wu, Y., Lui, E.M.K., Chakrabarti, S. (2012) Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy. Phytomedicine (2012), doi:10.1016/j.phymed.2012.01.001. Article
  18. Lemmon, Holly Rebecca, "Modulatory Effects Of North American Ginseng Extracts On Human Innate and Adaptive Immune Responses" (2012). Electronic Thesis and Dissertation Repository. Paper 399. (MSc thesis) Article
  19. Estaki, M., E.G. Noble (2012) Differences in alcohol versus aqueous extracts of North American Ginseng in protecting against eccentric exercise-induced muscle damage in rats. FASEB J March 29, 2012 26:1141.5. Article
  20. Sen, S., Chen, S., Wu, Y., Feng, B., Lui, E.M.K. and Chakrabarti, S. (2012) Preventive effects of North American Ginseng (Panax quinquefolius) on Diabetic Retinopathy and Cardiomyopathy. PHYTOTHERAPY RESEARCH Phytother. Res. Published online in Wiley Online Library. DOI: 10.1002/ptr.4719 Article
  21. Wilson, S.A.F, Wong, M.H.T., Stryjecki, C., De Boer, A., Lui, E.M.K. and Mutch, D.M. (2012)Unraveling the adipocyte inflammomodulatory pathways activated by North American ginseng. International Journal of Obesity advance online publication, 17 April 2012; doi:10.1038/ijo.2012.50.
  22. Moey, M., Gan, X.T., Huang, C.X., Rajapurohitam, V., Martínez-Abundis, E., Lui E.M.K. and Karmazyn, M. (2012) Ginseng Reverses Established Cardiomyocyte Hypertrophy and Post Myocardial Infarction-Induced Hypertrophy and Heart Failure. Circulation: Heart Failure. 2012; 5: 504-514 Published online before print May 10, 2012, doi: 10.1161/CIRCHEARTFAILURE. 112.967489 Article
  23. Bowie, L. E., Roscoe, W. A., Lui, E.M.K., Smith, R., Karlick, S.J. (2012) Effects of an aqueous extract of North American ginseng on MOG(35–55)-induced EAE in mice. Canadian Journal of Physiology and Pharmacology, 2012, 90(7): 933-939, 10.1139/y2012-092. Article
  24. Belanger, Danyka D., "Ginseng Extract Treatment Influences on Preimplantation Development in Vitro, and Pregnancy and Post-Partum Development in the Mouse" (2012). Electronic Thesis and Dissertation Repository. Paper 577. (MSc thesis) Article
  25. Migchels, Megan J., "Chronic North American Ginseng Administration Alters Metabolic and Cardiovascular Variables in the Rat" (2012). Electronic Thesis and Dissertation Repository. Paper 792. (MSc thesis) Article
  26. Ratnesh Kumar Singh, Morgan D. Fullerton, Donna Vine and Marica Bakovic.  "Mechanism of hypertriglyceridemia in CTP:phosphoethanolamine cytidylyltransferase-deficient mice." September 2012 The Journal of Lipid Research, 53, 1811-1822. Article
  27. Misagh Alipour, Abdelwahab Omri, Edmund M.K. Lui, and Zacharias E. Suntres. "Co-administration of aqueous ginseng extract with tobramycin stimulates the pro-inflammatory response and promotes the killing of Pseudomonas aeruginosa in the lungs of infected rats." Canadian Journal of Physiology and Pharmacology, 2013, 91:935-940. Article
  28. Sen S, Querques MA, Chakrabarti S. "North American Ginseng (Panax quinquefolius) prevents hyperglycemia and associated pancreatic abnormalities in diabetes." Journal of Medicinal Food, 2013, 16:587-92. Article


Advanced Processing

  1. Sima Manifar. "Flow Enhancement of Ginseng and other Fine Powders with Rotating and Conventional Fluidized Beds" (2013). Electronic Thesis and Dissertation Repository. Paper 1161. (MSc thesis) Article
  2. Adriana Cimo, Mohammad Soltani, Edmund Lui and Sharareh Hekmat   Fortification of probiotic yogurt with ginseng (Panax quinquefolius) extract.  Journal of Food & Nutritional Disorders,2013, 2:2




Knowledge Translation

  1. Ning, A. (2011) Fluid Boundaries: Conventional and Complementary/Alternative Medicine Examine. The International Journal of Health, Wellness and Society, Volume 1, Issue 2, pp.161-176. Article
  2. Ning, A. (2012) How 'Alternative' is CAM? Rethinking Conventional Dichotomies between Biomedicine and Complementary/Alternative Medicine. Health: An Interdisciplinary Journal for the Social Study of Health, Illness and Medicine


Commercialization & IP