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Selected Original Publications:


  1. Zhang T, Lu X, Beier F, Feng Q. Rac1 activation induces tumor necrosis factor-alpha expression and cardiac dysfunction in endotoxemia. J Cell Mol Med, 2010 in press.
  2. Xenocostas A, Hu H, Chin-Yee N, Lu X, Chin-Yee I, Feng Q. Erythropoietin is equally effective as fresh blood transfusion at reducing infarct size in anemic rats. Critical Care Medicine. 2010; 38:2215-2221.
  3. Xiang FL, Lu X, Strutt B, Hill DJ, Feng Q. NOX2 deficiency protects against streptozotocin-induced cell destruction and development of diabetes in mice. Diabetes. 2010; 50:2603-2610. | PDF
  4. Hu H, Xenocostas A, Chin-Yee I, Lu X, Feng Q. Effects of anemia and blood transfusion in acute myocardial infarction in rats. Transfusion. 2010; 50:243-251. | PDF
  5. Xiang FL, Lu X, Hammoud L, Zhu P, Robbins J, Feng Q. Cardiomyocyte specific overexpression of human stem cell factor improves cardiac function and survival post myocardial infarction in mice. Circulation. 2009; 120:1065-1074. | PDF
  6. Burger D, Lu X, Lei M, Xiang F, Hammoud L, Jiang M, Wang H, Jones DL, Sims SM, Feng Q. Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation. 2009; 120:1345-1354. | PDF
  7. Burger D, Xiang FL, Hammoud L, Jones DL, Feng Q. Erythropoietin protects the heart from ventricular arrhythmia during ischemia and reperfusion via neuronal nitric oxide synthase. J Pharmacol Exp Ther. 2009; 329:900-907. | PDF
  8. Li N, Lu X, Zhao X, Xiang FL, Xenocostas A, Karmazyn M, Feng Q. Endothelial nitric oxide synthase promotes mesenchymal stromal cell migration towards the ischemic myocardium through upregulation of SDF-1alpha. Stem Cells. 2009; 27:961-970. | PDF
  9. Peng T, Zhang T, Lu X, Feng Q. JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxemia. Cardiovasc Res. 2009; 81:733-741. | PDF
  10. Hammoud L, Burger D, Lu X, Feng Q. Tissue inhibitor of metalloproteinase-3 inhibits neonatal mouse cardiomyocyte proliferation via EGFR/JNK/SP-1 signaling. Am J Physiology: Cell Physiol. 2009; 296:C735-C745. | PDF
  11. Burger D, Xiang F, Hammoud L, Lu X, Feng Q. Role of heme oxyenase-1 in the cardioprotective effects of erythropoietin during myocardial ischemia and repefusion. Am J Physiology: Heart and Circ Physiol. 2009; 296:H84-H93. | PDF
  12. Peng T, Shen E, Fan J, Zhang Y, Arnold JM, Feng Q. Disruption of phospholipase Cgamma1 signalling attenuates cardiac tumor necrosis factor-alpha expression and improves myocardial function during endotoxemia. Cardiovasc Res. 2008;78:90-97. | PDF
  13. Hammoud L, Xiang F, Lu X, Brunner F, Leco K, Feng Q. Endothelial nitric oxide synthase promotes neonatal cardiomyocyte proliferation by inhibiting tissue inhibitor of metalloproteinase-3 expression. Cardiovasc Res. 2007; 75:359-68. | PDF
  14. Geoghegan-Morphet N, Burger D, Lu X, Sathish V, Peng T, Sims SM, Feng Q. Role of neuronal nitric oxide synthase in lipopolysaccharide-induced tumor necrosis factor-alpha expression in neonatal mouse cardiomyocytes. Cardiovasc Res. 2007; 75:408-416. Corrigendum published in Cardiovasc Res. 2007; 81:814. | PDF
  15. Lu X, Hamilton JA, Shen Ji, Jones DL, Potter RF, Arnold JMO, Feng Q. Role of tumor necrosis factor-alpha in myocardial dysfunction and apoptosis during hindlimb ischemia and reperfusion. Critical Care Medicine. 2006; 34:484-491. | PDF
  16. Burger D, Lei M, Geoghegan-Morphet N, Lu X, Xenocostas A, Feng Q. Erythropoietin protects cardiomyocytes from apoptosis via up-regulation of endothelial nitric oxide synthase. Cardiovascular Res. 2006; 72:51-59. This paper was one of most downloaded papers in this journal in 2006 (see Cardiovasc Res 73:619-622, 2007). | PDF
  17. Lepic E, Burger D, Lu X, Song W, Feng Q. Lack of endothelial nitric oxide synthase decreases cardiomyocyte proliferation and delays cardiac maturation. Am J Physiol: Cell Physiol. 2006; 291:C1240-C1246. | PDF
  18. Peng T, Lu X, Feng Q. NADH oxidase signalling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB J. 2005;19:293-295. | PDF
  19. Peng T, Lu X, Feng Q. Pivotal role of gp91phox-containing NADH oxidase in lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression. Circulation. 2005;111:1637-1644. | PDF
  20. Peng T, Lu X, Lei M, Feng Q. Endothelial nitric oxide synthase enhances lipopolysaccharide-stimulated TNF-alpha expression via cAMP-mediated p38 MAPK pathway in cardiomyocytes. J Biol Chem. 2003;278:8099-8105. | PDF
  21. Peng T, Lu X, Lei M, Moe GW, Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival during acute endotoxemia in mice. Cardiovasc Res. 2003;59:893-900. | PDF
  22. Zhao X, Lu X, Feng Q. Deficiency in endothelial nitric oxide synthase impairs myocardial angiogenesis in mice. Am J Physiology: Heart Circ Physiol. 2002; 283:H2371-H2378. | PDF
  23. Feng Q, Song W, Lu X, Hamilton J, Lei M, Peng T, Yee SP. Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation. 2002;106:873-879. This paper was featured on the cover of Circulation on Aug. 13, 2002. | PDF
  24. Feng Q, Lu X, Jones DL, Shen J, Arnold JMO. Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality post myocardial infarction in mice. Circulation. 2001; 104:700-704. | PDF
  25. Stathopulos PB, Lu X, Shen J, Scott JA, Hammond JR, McCormack DG, Arnold JMO, Feng Q. Increased L-arginine uptake and inducible nitric oxide activity in aortas of rats with heart failure. Am J Physiol, Heart Circ Physiol. 2001; 280:H859-H867. | PDF
  26. Song W, Lu X, Feng Q. Tumor necrosis factor-alpha induces apoptosis via inducible nitric oxide synthase in neonatal mouse cardiomyocytes. Cardiovasc Res. 2000; 45:595-602. | PDF


Reviews and Editorials

  1. Zhang T, Feng Q. Nitric oxide and calcium signaling on myocardial tumor necrosis factor-alpha expression and cardiac dysfunction in sepsis (Review). Can J Physiol Pharmacol. 2010; 88:92-104. | PDF
  2. Burger D, Xenocostas A, Feng Q. Molecular basis of cardioprotection by erythropoietin (Review). Current Mol Pharmacol. 2009; 2:56-69. | PDF
  3. Feng Q. Beyond erythropoiesis, the anti-inflammatory effects of erythropoietin (Editorial). Cardiovasc Res. 2006; 71:615-617. | PDF
  4. Razavi HM, Hamilton JA, Feng Q. Modulation of apoptosis by nitric oxide: Implications in myocardial ischemia and heart failure (Review). Pharmacology & Therapeutics. 2005; 106:147-162. | PDF
  5. Feng Q. Postnatal consequences of prenatal cocaine exposure and myocardial apoptosis: Does cocaine in utero imperil the adult heart (Commentary)? Br J Pharmacol. 2005; 144:887-888. | PDF