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Rechnitzer Lecture

Muscle Microcirculation in Healthy Ageing:
Inconvenient Truths

Dr. David Poole
Professor of Kinesiology, Anatomy and Physiology
Kansas State University in Manhattan, Kansas
Visiting Professor in the School of Sports and Health Sciences
Exeter University in the U.K

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Dr. David Poole
Professor of Kinesiology, Anatomy and Physiology
Kansas State University in Manhattan, Kansas
Visiting Professor in the School of Sports and Health Sciences
Exeter University in the U.K

Dr. Poole's scientific interests encompass the limitation to oxygen transport in the lungs, cardiovascular and muscular systems in health (and healthy ageing) and in diseases such as chronic heart failure, diabetes and emphysema.  He has an international reputation for his work on the dynamics of oxygen movement and how this process is impaired in disease.  His films of red blood cells moving through capillaries as they off-load oxygen are used to teach undergraduate, graduate and medical students at Kansas State and internationally.  Through analysis of such films, his laboratory seeks to understand oxygen delivery to tissues, how this process is impaired in disease, and to find ways of minimizing this impairment.  This is crucial to improving the quality of life and longevity in healthy individuals and especially in patients living with chronic disease.


Lecture Abstract:

Muscle Microcirculation in Healthy Ageing: Inconvenient Truths

Exercising skeletal muscle energy demands are prodigious and oxygen supplying those demands must cross the capillary blood-myocyte interface.  Humans have nearly ten billion muscle capillaries with a cumulative length of about seven thousand miles, and yet our understanding of red blood cell movement and oxygen off-loading in those capillaries is rudimentary at best.  Worse still, dogmatic (and incorrect) notions of microcirculatory behaviour pervade the literature and impede progress in this important field.  Dr. Poole's lecture will examine critically some of those dogmas, present state-of-the-art evidence to oppose them, and explore how changes in microcirculatory function in ageing muscle might help explain impaired muscle oxygen utilization and exercise function.

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Don Paterson
Research Director
Candian Centre for Activity and Aging
Phone: 519.661.1606 x81606
Email: dpaterso@uwo.ca

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