Pharmacology & Toxicology: 1998-1999

Bailey, D.G., J.M.O. Arnold, and J.D. Spence. 1998. Grapefruit juice-drug interactions. British Journal of Clinical Pharmacology 46: 101-110.

Humphreys, R.A., J.V. Haist, S. Chakrabarti, Q. Feng, J.M.O. Arnold, and M. Karmazyn. 1999. Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. American Journal of Physiology 276 (45): H749-H757.

Bailey, D.G., J.M.O. Arnold, and J.D. Spence. 1998. Grapefruit juice-drug interactions. British Journal of Clinical Pharmacology 46: 101-110.

Bailey, D.G., J.H. Kreeft, C. Munoz, D.J. Freeman, and J.R. Bend. 1998. Grapefruit juice-felodipine interaction: Effect of naringin and and 6', 7' - dihydroxybergamottin in humans. Clinical Pharmacology and Therapeutics 64 (3): 248-256.

Hall, S.D., K.E. Thummel, P.B. Watkins, K.S. Lown, L.Z. Benet, M.F. Paine, R.R. Mayo, D.K. Turgeon, D.G. Bailey, R.J. Fontana, and S.A. Wrighton. 1999. Molecular and physical mechanisms of first-pass extraction. Drug Metabolism and Disposition 27 (2): 161-166.

Bailey, D.G., J.H. Kreeft, C. Munoz, D.J. Freeman, and J.R. Bend. 1998. Grapefruit juice-felodipine interaction: Effect of naringin and and 6', 7' - dihydroxybergamottin in humans. Clinical Pharmacology and Therapeutics 64 (3): 248-256.

Sinal, C.J., M. Hirst, C.D. Webb, and J.R. Bend. 1998. Enantioselective, mechanism-based inactivation of guinea pig hepatic cytochrome P450 by N-(a-methylbenzyl)-1-aminobenzotriazole. Drug Metabolism and Disposition 26 (7): 681-688.

Sinal, C.J., C.D. Webb, and J.R. Bend. 1999. Differential in vivo effects of a-naphthoflavone and ß-naphthoflavone on CYP1A1 and CYP2E1 in rat liver, lung, heart, and kidney. Journal of Biochemistry and Molecular Toxicology 13 (1): 29-40.

Burke, T., S. Lee, P.J. Ferguson, and J.R. Hammond. 1998. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na⁺ -dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. Journal of Pharmacology and Experimental Therapeutics 286 (3): 1333-1340.

Chidiac, P., V.S. Markin, and E.M. Ross. 1999. Kinetic control of guanine nucleotide binding to soluble Ga_q. Biochemical Pharmacology 58: 39-48.

Chidiac, P., and E.M. Ross. 1999. Phospholipase C-ß1 directly accelerates GTP hydrolysis by Ga_q and acceleration is inhibited by Gßg subunits. The Journal of Biological Chemistry 274 (28): 19639-19643.

Ingi, T., A.M. Krumins, P. Chidiac, G.M. Brothers, S. Chung, B.E. Snow, C.A. Barnes, A.A. Lanahan, D.P. Siderovski, E.M. Ross, A.G. Gilman, and P.F. Worley. 1998. Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. The Journal of Neuroscience 18 (18): 7178-7188.

Zeng, W., X. Xu, S. Popov, S. Mukhopadhyay, P. Chidiac, J. Swistok, W. Danho, K.A. Yagaloff, S.L. Fisher, E.M. Ross, S. Muallem, and T.M. Wilkie. 1998. The N-terminal domain of RGS4 confers receptor-selective inhibition of G protein signaling. The Journal of Biological Chemistry 273 (52): 34687-34690.

Deshpande, N.A., T.J. McDonald, and M.A. Cook. 1999. Endogenous interstitial adenosine in isolated myenteric neural networks varies inversely with prevailing PO₂. American Journal of Physiology 276 (39): G875-G885.

Thomas, G.P., S.M. Sims, M.A. Cook, and M. Karmazyn. 1998. Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activitation. The Journal of Pharmacology and Experimental Therapeutics 286 (3): 1208-1214.

Callaghan, D.A., L. Dong, S.M. Callaghan, Y.X. Hou, L. Dagnino, and R.S. Slack. 1999. Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity. Developmental Biology 207: 257-270.

Lindeman, G.J., L. Dagnino, S. Gaubatz, Y. Xu, R.T. Bronson, H.B. Warren, and D.M. Livingston. 1998. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes and Development 12: 1092-1098.

Deshpande, N.A., T.J. McDonald, and M.A. Cook. 1999. Endogenous interstitial adenosine in isolated myenteric neural networks varies inversely with prevailing PO₂. American Journal of Physiology 276 (39): G875-G885.

Humphreys, R.A., J.V. Haist, S. Chakrabarti, Q. Feng, J.M.O. Arnold, and M. Karmazyn. 1999. Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. American Journal of Physiology 276 (45): H749-H757.

Burke, T., S. Lee, P.J. Ferguson, and J.R. Hammond. 1998. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na⁺ -dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. Journal of Pharmacology and Experimental Therapeutics 286 (3): 1333-1340.

Hammond, J.R., S. Lee, and P.J. Ferguson. 1999. [³H]Gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. The Journal of Pharmacology and Experimental Therapeutics 288 (3): 1185-1191.

Bailey, D.G., J.H. Kreeft, C. Munoz, D.J. Freeman, and J.R. Bend. 1998. Grapefruit juice-felodipine interaction: Effect of naringin and and 6', 7' - dihydroxybergamottin in humans. Clinical Pharmacology and Therapeutics 64 (3): 248-256.

Humphreys, R.A., J.V. Haist, S. Chakrabarti, Q. Feng, J.M.O. Arnold, and M. Karmazyn. 1999. Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. American Journal of Physiology 276 (45): H749-H757.

Burke, T., S. Lee, P.J. Ferguson, and J.R. Hammond. 1998. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na⁺ -dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. Journal of Pharmacology and Experimental Therapeutics 286 (3): 1333-1340.

Hammond, J.R., S. Lee, and P.J. Ferguson. 1999. [³H]Gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. The Journal of Pharmacology and Experimental Therapeutics 288 (3): 1185-1191.

Mani, R.S., J.R. Hammond, J.M.J. Marjan, K.A. Graham, J.D. Young, S.A. Baldwin, and C.E. Cass. 1998. Demonstration of equilibrative nucleoside transporters (hENT1 and hENT2) in nuclear envelopes of cultured human choriocarcinoma (BeWo) cells by functional reconstitution in proteoliposomes. The Journal of Biological Chemistry 273 (46): 30818-30825.

Sinal, C.J., M. Hirst, C.D. Webb, and J.R. Bend. 1998. Enantioselective, mechanism-based inactivation of guinea pig hepatic cytochrome P450 by N-(a-methylbenzyl)-1-aminobenzotriazole. Drug Metabolism and Disposition 26 (7): 681-688.

Twiner, M.J., M. Hirst, A. Valenciano, T.R. Zacharewski, and S.J. Dixon. 1998. N,N-Dimethylformamide modulates acid extrusion from murine hepatoma cells. Toxicology and Applied Pharmacology 153: 143-151.

Humphreys, R.A., J.V. Haist, S. Chakrabarti, Q. Feng, J.M.O. Arnold, and M. Karmazyn. 1999. Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. American Journal of Physiology 276 (45): H749-H757.

Humphreys, R.A., J.V. Haist, S. Chakrabarti, Q. Feng, J.M.O. Arnold, and M. Karmazyn. 1999. Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion. American Journal of Physiology 276 (45): H749-H757.

Thomas, G.P., M. Karmazyn, A.C. Zygmunt, C. Antzelevitch, and N. Narayanan. 1999. The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. British Journal of Pharmacology 126: 1531-1533.

Thomas, G.P., S.M. Sims, M.A. Cook, and M. Karmazyn. 1998. Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activitation. The Journal of Pharmacology and Experimental Therapeutics 286 (3): 1208-1214.

Bailey, D.G., J.H. Kreeft, C. Munoz, D.J. Freeman, and J.R. Bend. 1998. Grapefruit juice-felodipine interaction: Effect of naringin and and 6', 7' - dihydroxybergamottin in humans. Clinical Pharmacology and Therapeutics 64 (3): 248-256.

Burke, T., S. Lee, P.J. Ferguson, and J.R. Hammond. 1998. Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na⁺ -dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells. Journal of Pharmacology and Experimental Therapeutics 286 (3): 1333-1340.

Hammond, J.R., S. Lee, and P.J. Ferguson. 1999. [³H]Gemcitabine uptake by nucleoside transporters in a human head and neck squamous carcinoma cell line. The Journal of Pharmacology and Experimental Therapeutics 288 (3): 1185-1191.

Deshpande, N.A., T.J. McDonald, and M.A. Cook. 1999. Endogenous interstitial adenosine in isolated myenteric neural networks varies inversely with prevailing PO₂. American Journal of Physiology 276 (39): G875-G885.

Bailey, D.G., J.M.O. Arnold, and J.D. Spence. 1998. Grapefruit juice-drug interactions. British Journal of Clinical Pharmacology 46: 101-110.

Thomas, G.P., M. Karmazyn, A.C. Zygmunt, C. Antzelevitch, and N. Narayanan. 1999. The antifungal antibiotic clotrimazole potently inhibits L-type calcium current in guinea-pig ventricular myocytes. British Journal of Pharmacology 126: 1531-1533.

Thomas, G.P., S.M. Sims, M.A. Cook, and M. Karmazyn. 1998. Hydrogen peroxide-induced stimulation of L-type calcium current in guinea pig ventricular myocytes and its inhibition by adenosine A1 receptor activitation. The Journal of Pharmacology and Experimental Therapeutics 286 (3): 1208-1214.

Sinal, C.J., M. Hirst, C.D. Webb, and J.R. Bend. 1998. Enantioselective, mechanism-based inactivation of guinea pig hepatic cytochrome P450 by N-(a-methylbenzyl)-1-aminobenzotriazole. Drug Metabolism and Disposition 26 (7): 681-688.

Sinal, C.J., C.D. Webb, and J.R. Bend. 1999. Differential in vivo effects of a-naphthoflavone and ß-naphthoflavone on CYP1A1 and CYP2E1 in rat liver, lung, heart, and kidney. Journal of Biochemistry and Molecular Toxicology 13 (1): 29-40.

Twiner, M.J., M. Hirst, A. Valenciano, T.R. Zacharewski, and S.J. Dixon. 1998. N,N-Dimethylformamide modulates acid extrusion from murine hepatoma cells. Toxicology and Applied Pharmacology 153: 143-151.