Researcher Profile

Wataru Inoue

Assistant Professor

BMI Associate Member

Department(s):
Physiology & Pharmacology

Publications:

Associated Websites:

Contact Information:

winoue@robarts.ca
(519) 931-5777 x24373
RRI 7233

Research Areas

Profile

The goal of my research is to understand the effects of stress on the functioning of the brain, and consequently behaviour. My lab uses a multidisciplinary approach including patch clamp electrophysiology, optogenetics, biochemical & histological analysis, and behavioral & physiological manipulations in order to understand molecular mechanisms of stress.

Stress causes an immediate physiological and psychological response and promotes associative learning that makes a lasting changes in future behavior; however, the accumulations of memories of stressful episodes can cause many negative consequences. I focus my work on the hypothalamus, which is the part of the brain that regulates hormonal response to stress. Stress-induced changes in this area may represent a key neurobiological mechanism for the abnormality of stress hormone levels and the changes in behaviour, seen in many serious diseases. Thus, I aim to understand the fundamental cellular and molecular mechanisms through which stressful experiences influence neural and synaptic plasticity in specific stress-related brain circuits, examine how different modalities, intensities and durations of stress cause different types of neural plasticity, and investigate causal relationships between stress-associative neural plasticity and the changes in physiological functions and behavior.