BMI Associate Member
Physiology & Pharmacology, Anatomy & Cell Biology
(519) 663-5777 x24889
Dr. Vania Prado’s main interest is the cholinergic system. Altered release of the cholinergic transmitter acetylcholine seems to underlie some of the cognitive and behavioural deficits observed in patients with age-related dementia. She has generated a collection of genetically modified mice to test the role of cholinergic transporters for maintaining synthesis and storage of acetylcholine in nerve terminals. The aim of this research is to test the possibility of using cholinergic transporters as drug targets to improve acetylcholine release, an important therapeutic approach in dementia (such as Alzheimer’s, Huntington’s and Parkinson’s disease), myasthenia and other disturbances of the cholinergic system.