Leaders in Learning: Publications of Faculty & Staff

Microbiology & Immunology 2003-2004


Boyd, N.D., B.M. Chan, and N.O. Petersen. 2003. Beta1 integrins are distributed in adhesion structures with fibronectin and caveolin and in coated pits. Biochemical Cell Biology 18 (5): 335-348.

Li, S., C. Van Den Diepstraten, S.J. D'Souza, B.M. Chan, and J.G. Pickering. 2003. Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization. American Journal of Pathology 163 (3): 1045-1056.


Chen, W., K.V. Salojin, Q.S. Mi, M. Grattan, T.C. Meagher, P. Zucker, and T.L. Delovitch. 2004. (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Endocrinology 145 (2): 1303-1310.

Mi, Q.S., D. Ly, S.E. Lamhamedi-Cherradi, K.V. Salojin, L. Zhou, M. Grattan, C. Meagher, P. Zucker, Y.H. Chen, J. Nagle, D. Taub, and T.L. Delovitch. 2003. Blockade of TNF-related apoptosis-inducing ligand (TRAIL) exacerbates autoimmune type 1 diabetes in NOD mice. Diabetes 52 (8): 1967-1975.

Mi, Q.S., D. Ly, P. Zucker, M. McGarry, and T.L. Delovitch. 2004. Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells. Diabetes 53 (5): 1303-1310.

Mi, Q.S., C. Meagher, and T.L. Delovitch. 2003. CD1d-restricted NKT regulatory cells: functional genomic analyses provide new insights into the mechanisms of protection against Type 1 diabetes. Novartis Foundation Symposium 252 252: 146-160.


Flintoff, W.F., F.M.R. Williams, and H. Sadlish. 2003. The Region between Transmembrane Domains 1 and 2 of the Reduced Folate Carrier Forms Part of the Substrate-binding Pocket. Journal of Biological Chemistry 278 (42): 40867-40876.

Neumann, K., K.M. Al-Batayneh, M.J. Kuiper, Parsons-Sheldrake. J., M.G. Tyshenko, Flintoff. W.F., S.P. Cole, and V.K. Walker. 2003. A single point mutation in Drosophila dihydrofolate reductase confers methotrexate resistance to a transgenic CHO cell line. Genome 46 (4): 707-715.


Dale, S.E., A. Doherty-Kirby, G. Lajoie, and D.E. Heinrichs. 2004. Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophore. Infection and Immunity 72 (1): 29-31.

Sebulsky, M.T., B.H. Shilton, C.D. Speziali, and D.E. Heinrichs. 2004. The role of FhuD2 in iron(III)-hydroxamate transport in Staphylococcus aureus. Demonstration that FhuD2 binds iron(III)-hydroxamates but with minimal conformational change and implication of mutations on transport. Journal of Biological Chemistry 278 (50): 49890-49900.


Elsayed, S., O. Hammerberg, V. Massey, and Z. Hussain. 2003. Streptococcus equi subspecies equi (Lancefield group C) meningitis in a child. Cliical Microbiology and Infection 8 (Aug): 869-872.


Fällman, E., S. Schedin, J. Jass, M. Andersson, B.E. Uhlin, and O. Axner. 2004. Optical tweezers based force measurement system for quantitating binding interactions: system design and application for the study of bacterial adhesion. Biosensors & Bioelectronics 19 (11): 1429-1437.

Malisauskas, M., V. Zamotin, J. Jass, W. Noppe, C.M. Dobson, and L.A. Morozova-Roche. 2003. Amyloid protofilaments from the calcium-binding protein equine lysozyme: formation of ring and linear structures depends on pH and metal ion concentration. Journal of Molecular Biology 330 (4): 879-890.

Wai, S.N., S. Lindmark, T. Söderblom, A. Takade, M. Westermark, J. Oscarsson, J. Jass, A. Richter-Dahlfors, M. Mizunoe, and B.E. Uhlin. 2003. Vesicle-Mediated Export and Assembly of Pore-Forming Oligomers of the Enterobacterial ClyA toxin. Cell 115: 25-35.

Wai, S.N., M. Westermark, J. Oscarsson, J. Jass, E. Maier, R. Benz, and B.E. Uhlin. 2003. Characterization of dominantly negative mutant ClyA cytotoxin proteins in Escherichia coli. Journal of Bacteriology 185 (18): 5491-5499.


Arp, J., M.G. Kirchhof, M.L. Baroja, S.H. Nazarian, T.A. Chau, C.A. Strathdee, E.H. Ball, and J. Madrenas. 2004. Regulation of T-cell activation by phosphodiesterase 4B2 requires its dynamic redistribution during immunological synapse formation. Molecular Cell Biology 23 (22): 8042-8057.

Baroja, M.L., and J. Madrenas. 2003. Viewpoint: therapeutic implications of CTLA-4 compartmentalization. American Journal of Transplantation 3 (8): 919-926.

Criado, G., and J. Madrenas. 2004. Superantigen stimulation reveals the contribution of Lck to negative regulation of T cell activation. Journal of Immunology 172 (1): 222-230.

Giguere, J.F., S. Bounou, J.S. Paquette, J. Madrenas, and M.J. Tremblay. 2004. Insertion of host-derived costimulatory molecules CD80 (B7.1) and CD86 (B7.2) into human immunodeficiency virus type 1 affects the virus life cycle. Journal of Virology 78 (12): 6222-6232.

Li, L., M.L. Baroja, A. Majumdar, K. Chadwick, A. Rouleau, L. Gallacher, I. Ferber, J. Lebkowski, M.J. Martin T, and M. Bhatia. 2004. Human embryonic stem cells possess immune-privileged properties. Stem Cells 22 (4): 448-456.

Madrenas, J., L.A. Chau, W.A. Teft, P.W. Wu, J. Jussif, M. Kasaian, B.M. Carreno, and V. Ling. 2004. Conversion of CTLA-4 from inhibitor to activator of T cells with a bispecific tandem single-chain Fv ligand. Journal of Immunology 172 (10): 5948-5956.

Siu, E., B.M. Carreno, and J. Madrenas. 2004. TCR subunit specificity of CTLA-4-mediated signaling. Journal of Leukocyte Biology 74 (6): 1102-1107.

Yu, X.Z., S.D. Levin, J. Madrenas, and C. Anasetti. 2004. Lck is required for activation-induced T cell death after TCR ligation with partial agonists. Journal of Immunology 172 (3): 1437-1443.


Cadieux, P.A., D.T. Beiko, J.D. Watterson, J.P. Burton, J.C. Howard, B.E. Knudsen, B.S. Gan, J.K. McCormick, A.F. Chambers, J.D. Denstedt, and G. Reid. 2004. Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis. Journal of Clinica Laboratory Analysis 18 (3): 170-175.

Dinges, M.M., D.S. Gregerson, T.J. Tripp, J.K. McCormick, and P.M. Schlievert. 2003. Effects of total body irradiation and cyclosporin a on the lethality of toxic shock syndrome toxin-1 in a rabbit model of toxic shock syndrome. Journal of Infectious Diseases 188 (2): 1142-1145.

McCormick, J.K., T.J. Tripp, A.S. Llera, E.J. Sundberg, M.M. Dinges, R.A. Mariuzza, and P.M. Schlievert. 2003. Functional analysis of the TCR binding domain of toxic shock syndrome toxin-1 predicts further diversity in MHC class II/superantigen/TCR ternary complexes. Journal of Immunology 171 (3): 1385-11392.

Reid, G., J. Jass, M.T. Sebulsky, and J.K. McCormick. 2003. Potential uses of probiotics in clinical practice. Clinical Microbiological Review 16 (4): 658-672.

Waters, C.M., H. Hirt, J.K. McCormick, P.M. Schlievert, C.L. Wells, and G.M. Dunny. 2004. An amino-terminal domain of Enterococcus faecalis aggregation substance is required for aggregation, bacterial internalization by epithelial cells and binding to lipoteichoic acid. Molecular Microbiology 52 (4): 1159-1171.


Bedard, E.L., P. Kim, J. Jiang, N. Parry, L. Liu, H. Wang, B. Garcia, X. Li, G. McFadden, A. Lucas, and R. Zhong. 2003. Chemokine-binding viral protein M-T7 prevents chronic rejection in rat renal allografts. Transplantation 76 (1): 249-252.

Brunetti, C.R., H. Amano, Y. Ueda, J. Qin, T. Miyamura, T. Suzuki, X. Li, J.W. Barrett, and G. McFadden. 2003. Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus. Journal of Virology 77 (24): 13335-13347.

Liu, L., E. Dai, L. Miller, B. Seet, A. Lalani, C. Macauley, X. Li, H.W. Virgin, C. Bunce, P. Turner, R. Moyer, G. McFadden, and A. Lucas. 2004. Viral chemokine-binding proteins inhibit inflammatory responses and aortic allograft transplant vasculopathy in rat models. Transplantation 77 (11): 1652-1660.

Seet, B.T., C.A. McCaughan, T.M. Handel, A. Mercer, C. Brunetti, G. McFadden, and S.B. Fleming. 2003. Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proceedings of the National Academy of Science U.S.A 100 (25): 15137-15142.

Seet, B.T., and G. McFadden. 2004. Interaction analysis of viral cytokine-binding proteins using surface plasmon resonance. Methods in Molecular Biology 269: 219-242.


Ichim, T.E., R. Zhong, and W.P. Min. 2003. Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells. Transplant Immunology 11 (3-4): 295-306.


Beiko, D.T., B.E. Knudsen, J.D. Watterson, P.A. Cadieux, G. Reid, and J.D. Denstedt. 2004. Urinary tract biomaterials. Journal of Urology 171 (6): 2438-2444.

Burton, J.P., E. Devillard, P.A. Cadieux, J.A. Hammond, and G. Reid. 2004. Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation. Journal of Clinical Microbiology 42 (4): 1829-1831.

Reid, G., and A. Bocking. 2003. The potential for probiotics to prevent bacterial vaginosis and preterm labor. American Journal of Obstetrics and Gynecology 189 (4): 1202-1208.

Reid, G., and A.W. Bruce. 2003. Urogenital infections in women: can probiotics help? Postgraduate Medical Journal 79 (934): 428-432.

Reid, G., J. Burton, and E. Devillard. 2004. The rationale for probiotics in female urogenital healthcare. Medscape General Medicine 6 (1): 49.

Reid, G., J. Burton, J.A. Hammond, and A.W. Bruce. 2004. Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli. Journal of Medicinal Food 7 (2): 223-228.

Reid, G., M.E. Sanders, H.R. Gaskins, G.R. Gibson, A. Mercenier, R. Rastall, M. Roberfroid, I. Rowland, C. Cherbut, and T.R. Klaenhammer. 2003. New scientific paradigms for probiotics and prebiotics. Jouranl of Clinical Gastroenterology 37 (2): 105-118.

Watterson, J.D., P.A. Cadieux, D. Stickler, G. Reid, and J.D. Denstedt. 2003. Swarming of Proteus mirabilis over ureteral stents: a comparative assessment. Journal of Endourology 17 (7): 523-527.


Marleau, A.M., J.D. Greenwood, Q. Wei, B. Singh, and B.A. Croy. 2003. Chimerism of murine fetal bone marrow by maternal cells occurs in late gestation and persists into adulthood. Laboratory Investigation 83 (5): 673-681.

Mukherjee, R., P. Chaturvedi, H.Y. Qin, and B. Singh. 2003. CD4+CD25+ regulatory T cells generated in response to insulin B:9-23 peptide prevent adoptive transfer of diabetes by diabetogenic T cells. Ournal of Autoimmunity 21 (3): 221-237.

Singh, B. 2003. Innovation and challenges in funding rapid research responses to emerging infectious diseases: Lessons learned from the outbreak of severe acute respiratory syndrome. Canadian Journal of Infectious Diseases and Medical Microbiology 15 (3): 167-170.

Summers, K., A.M. Marleau, T.A. Stephens, J.L. Mahon, and B. Singh. 2004. Dendritic Cells and Immunoregulation in the Pathogenesis and Prevention of Type 1 Diabetes. Canadian Journal of Diabetes 28 (1): 20-29.

Summers, K.L., M.T. Behme, J.L. Mahon, and B. Singh. 2003. Characterization of dendritic cells in humans with type 1 diabetes. Annals of the New York Academy of Science 1005 : 226-229.


Bittner, M., S. Saldias, F. Altamirano, M.A. Valvano, and I. Contreras. 2004. RpoS and RpoN are involved in the growth-dependent regulation of rfaH transcription and O antigen expression in Salmonella enterica serovar Typhi. Microbial Pathogenesis 36 (1): 19-24.

Chamaillard, M., M. Hashimoto, Y. Horie, J. Masumoto, S. Qiu, L. Saab, Y. Ogura, A. Kawasaki, K. Fukase, S. Kusumoto, M.A. Valvano, S.J. Foster, T.W. Mak, G. Nunez, and N. Inohara. 2003. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nature Immunology 4 (7): 702-707.

Flannagan, R.S., M.A. Valvano, and S.F. Koval. 2004. Downregulation of the motA gene delays the escape of the obligate predator Bdellovibrio bacteriovorus 109J from bdelloplasts of bacterial prey cells. Microbiology 150 (3): 649-656.

Gray, J.E., P.R. Norton, R. Alnouno, C.L. Marolda, M.A. Valvano, and K. Griffiths. 2003. Biological efficacy of electroless-deposited silver on plasma activated polyurethane. Biomaterials 24 (16): 2759-2765.