Leaders in Learning: Publications of Faculty & Staff


Biochemistry 2002-2003



BEHME, M.T.

Behme, M.T., J. Dupre, and T.J. McDonald. 2003. Glucagon-like peptide I improved glycemic control in type I diabetes. BMC Endocrine Disorders 3: 1-9.



DUNN, S.D.

Lee, C.C., M. Revington, S.D. Dunn, and N.O. Petersen. 2003. The Lateral Diffusion of Selectively Aggregated Peptides in Giant Unilamellar Vesicles. Biophysical Journal 84: 1756-1764.

Simmons, D.A., S.D. Dunn, and L. Konermann. 2003. Conformational Dynamics of Partially Denatured Myoglobin Studied by Time-Resolved Electrospray Mass Spectrometry with Online Hydrogen - Deuterium Exchange. Biochemistry 42: 5896-5905.



HAN, V.K.M.

Li, C., C. Iosef, C.Y.H. Jia, V.K.M. Han, and S.S.C. Li. 2003. Dual Functional Roles for the X-Linked Lymphoproliferative Syndrome Gene Product SAP/SH2D1A in Signaling through the Signaling Lymphocyte Activation Molecule (SLAM) Family of Immune Receptors. The Journal of Biological Chemistry 278: 3852-3859.



HANIFORD, D.B.

Stewart, B.J., S.J. Wardle, and D.B. Haniford. 2002. IHF-independent assembly of the Tn10 strand transfer transpososome: implications for inhibition of disintegration. The European Molecular Biology Organization Journal 21 (16): 4380-4390.



HEGELE, R.A.

Al-Shali, K., J. Wang, F. Rosen, and R.A. Hegele. 2003. Ileal adenocarcinoma in a mild phenotype of abetalipoproteinemia. Clinical Genetics 63: 135-138.

Argmann, C.A., C.G. Sawyez, C.J. McNeil, R.A. Hegele, and M.W. Huff. 2003. Activation of Peroxisome Proliferator-Activated Receptor Gamma and Retinoid X Receptor Results in Net Depletion of Cellular Cholesteryl Esters in Macrophages Exposed to Oxidized Lipoproteins. Arteriosclerosis, Thrombosis and Vascular Biology 23: 475-482.

Bhayana, S., V.M. Siu, G.I. Joubert, C.L. Clarson, H. Cao, and R.A. Hegele. 2002. Cardiomyopathy in congenital complete lipodystrophy. Clinical Genetics 61: 283-287.

Bjerregaard, P., E. Dewailly, T.K. Young, C. Blanchet, R.A. Hegele, S.E.O. Ebbesson, P.M. Risica, and G. Mulvad. 2003. Blood pressure among the Inuit (Eskimo) populations in the Arctic. Scandinavian Journal of Public Health 31: 92-99.

Bjerregaard, P., T.K. Young, and R.A. Hegele. 2003. Low incidence of cardiovascular disease among the Inuit - what is the evidence? Atherosclerosis 166: 351-357.

Burnett, J.R., J. Shan, B.A. Miskie, Whitfield A.J., J. Yuan, K. Tran, C.J. McKnight, R.A. Hegele, and Z. Yao. 2003. A Novel Nontruncating APOB Gene Mutation, R463W, Causes Familial Hypobetalipoproteinemia. The Journal of Biological Chemistry 278 (15): 13442-13452.

Cao, H., and R.A. Hegele. 2003. DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. Journal of Human Genetics 48: 20-22.

Cao, H., and R.A. Hegele. 2002. DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency. Journal of Human Genetics 47: 620-622.

Cao, H., and R.A. Hegele. 2003. LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). Journal of Human Genetics 48: 271-274.

Cao, H., B.A. Miskie, and R.A. Hegele. 2002. Functional promoter polymorphism in SREBP cleavage-activating protein (SCAP). Journal of Human Genetics 47: 492-496.

Cao, H., S. Shorey, J. Robinson, D.L. Metzger, L. Stewart, E. Cummings, and R.A. Hegele. 2002. GCK and HNF1A Mutation in Canadian Families With Maturity Onset Diabetes of the Young (MODY). Human Mutation 561: 1-3.

Carpentier, A., B. Zinman, N. Leung, A. Giacca, A.J.G. Hanley, S.B. Harris, R.A. Hegele, and G.F. Lewis. 2003. Free Fatty Acid-Mediated Impairment of Glucose-Stimulated Insulin Secretion in Nondiabetic Oji-Cree Individuals From the Sandy Lake Community of Ontario, Canada. Diabetes 52: 1485-1495.

DeVries, M.E., H. Cao, J. Wang, L. Xu, A.A. Kelvin, L. Ran, L.A. Chau, J. Madrenas, R.A. Hegele, and D.J. Kelvin. 2003. Genomic Organization and Evolution of the CX3CR1/CCR8 Chemokine Receptor Locus. The Journal of Biological Chemistry 278 (April 4th): 11985-11994.

Hegele, R.A. 2002. Genetic Lipodystrophies: Models for Insulin Resistance. Current Medicinal Chemistry 2: 245-250.

Hegele, R.A., H. Cao, C. Frankowski, S.T. Mathews, and T. Leff. 2002. PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy. Diabetes 51: 3586-3590.

Hegele, R.A., M.E. Kraw, M.R. Ban, B.A. Miskie, M.W. Huff, and H. Cao. 2003. Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophy. Arteriosclerosis, Thrombosis and Vascular Biology 23: 111-116.

Hegele, R.A., B. Zinman, A.J.B. Hanley, S.B. Harris, P.H. Barrett, and H. Cao. 2003. Genes, environment and Oji-Cree type 2 diabetes. Clinical Biochemistry 36: 163-170.

Mok, A., H. Cao, and R.A. Hegele. 2003. Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase. Geonomics 81: 1-5.

Mymin, D., J. Wang, J. Frohlich, and R.A. Hegele. 2003. Aortic Xanthomatosis With Coronary Ostial Occlusion in a Child Homozygous for a Nonsense Mutation in ABCG8. Circulation 107: 791.

Rocnik, E.F., E. van der Veer, H. Cao, R.A. Hegele, and J.G. Pickering. 2002. Functional Linkage between the Endoplascic Reticulum Protein Hsp47 and Procollagen Expression in Human Vascular Smooth Muscle Cells. The Journal of Biological Chemistry 277: 38571-38578.

Spence, J.D., M.R. Ban, and R.A. Hegele. 2003. Lipoprotein Lipase (LPL) Gene Variation and Progression of Carotid Artery Plaque. Stroke 34: 1176-1180.

Vukmirica, J., K. Tran, X. Liang, J. Shan, J. Yuan, B.A. Miskie, R.A. Hegele, M.D. Resh, and Z. Yao. 2003. Assembly and Secretion of Very Low Density Lipoproteins Containing Apolipoprotein B48 in Transfected McA-RH7777 Cells. The Journal of Biological Chemistry 278 (16): 14153-14161.

Walker, B.D., A.D. Krahn, G.J. Klein, A.C. Skanes, J. Wang, R.A. Hegele, and R. Yee. 2003. Congenital and acquired long QT syndromes. Canadian Journal of Cardiology 19 (1): 76-87.

Wang, J., and R.A. Hegele. 2003. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH). Human Genetics 112: 404-408.

Wang, J., X.Y. Wen, A.K. Stewart, and R.A. Hegele. 2002. Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1). Journal of Human Genetics 47: 611-613.

Wen, X.Y., R.A. Hegele, J. Wang, D.Y. Wang, J. Cheung, M. Wilson, M. Yahyapour, Y. Bai, L. Zhuang, J. Skaug, T.K. Young, P.W. Connelly, B.F. Koop, L.-C. Tsui, and K. Stewart. 2003. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Human Molecular Genetics 12 (10): 1131-1142.



HOWARD, J.C.

Howard, J.C., V.M. Varallo, D.C. Ross, J.H. Roth, K.J. Faber, B. Alman, and B.S. Gan. 2003. Elevated levels of b-catenin and fibronectin in three-dimensional collagen cultures of Dupuytren's disease cells are regulated by tension in vitro. BMC Musculoskeletal Disorders 4: 4-16.

Varallo, V.M., B.S. Gan, S. Seney, D.C. Ross, J.H. Roth, R.S. Richards, R.M. McFarlane, B. Alman, and J.C. Howard. 2003. Beta-catenin expression in Dupuytren's disease: potential role for cell-matrix interactions in modulating beta-catenin levels in vivo and in vitro. Oncogene 22: 3680-3684.



HUFF, M.W.

Argmann, C.A., C.G. Sawyez, C.J. McNeil, R.A. Hegele, and M.W. Huff. 2003. Activation of Peroxisome Proliferator-Activated Receptor Gamma and Retinoid X Receptor Results in Net Depletion of Cellular Cholesteryl Esters in Macrophages Exposed to Oxidized Lipoproteins. Arteriosclerosis, Thrombosis and Vascular Biology 23: 475-482.

Borradaile, N.M., L.E. de Dreu, P.H.R. Barret, C.D. Behrsin, and M.W. Huff. 2003. Hepatocyte ApoB-Containing Lipoprotein Secretion Is Decreased by the Grapefruit Flavonoid, Naringenin, via Inhibition of MTP-Mediated Microsomal Triglyceride Accumulation. Biochemistry 42 (5): 1283-1291.

Borradaile, N.M., L.E. de Dreu, P.H.R. Barrett, and M.W. Huff. 2002. Inhibition of hepatocyte apoB secretion by naringenin: enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. Journal of Lipid Research 43: 1544-1554.

Borradaile, N.M., L.E. de Dreu, L.J. Wilcox, J.Y. Edwards, and M.W. Huff. 2002. Soya phytoestrogens, genistein and daidzein, decrease apolipoprotein B secretion from HepG2 cells through multiple mechanisms. Biochemistry Journal 366: 531-539.

Burnett, J.R., and M.W. Huff. 2002. Avasimibe Pfizer. Current Opinion in Investigational Drugs 3 (9): 1328-1333.

Hegele, R.A., M.E. Kraw, M.R. Ban, B.A. Miskie, M.W. Huff, and H. Cao. 2003. Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophy. Arteriosclerosis, Thrombosis and Vascular Biology 23: 111-116.

Huff, M.W., D.E. Telford, J.Y. Edwards, J.R. Burnett, P.H.R. Barrett, S.R. Rapp, N. Napawan, and B.T. Keller. 2002. Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB. Arteriosclerosis, Thrombosis and Vascular Biology 22 (11): 1884-1891.

Telford, D.E., J.Y. Edwards, S.M. Lipson, B. Sutherland, P.H.R. Barrett, J.R. Burnett, E.S. Krul, B.T. Keller, and M.W. Huff. 2003. Inhibition of both the apical sodium-dependent bile acid transporter and HMG-CoA reductase markedly enhances the clearance of LDL apoB. Journal of Lipid Research 44 (5): 943-952.



JUNG, J.H.

Chun, K., A.S. Teebi, J.H. Jung, S. Kennedy, R. Laframboise, W.S. Meschino, K. Nakabayashi, S.W. Scherer, P.N. Ray, and I. Teshima. 2002. Genetic Analysis of Patients With the Saethre-Chotzen Phenotype. American Journal of Medical Genetics 110: 136-143.



KONERMANN, L.

Simmons, D.A., S.D. Dunn, and L. Konermann. 2003. Conformational Dynamics of Partially Denatured Myoglobin Studied by Time-Resolved Electrospray Mass Spectrometry with Online Hydrogen - Deuterium Exchange. Biochemistry 42: 5896-5905.



LAJOIE, G.

Donella-Deana, A., L. Cesaro, S. Sarno, M. Ruzzene, A.M. Brunati, O. Marin, G. Vilk, A. Doherty-Kirby, G. Lajoie, D.W. Litchfield, and L.A. Pinna. 2003. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochemical Journal 372: 841-849.



LEUNG, F.Y.

MacDonald, S.J., R.W. McCalden, D.G. Chess, R.B. Bourne, C.H. Rorabeck, D. Cleland, and F. Leung. 2003. Metal-on-Metal Versus Polyethylene in Hip Arthroplasty: A Randomized Clinical Trial. Clinical Orthopaedics and Related Research 406: 282-296.

Philp, R.B., F.Y. Leung, and C. Bradley. 2003. A Comparison of the Metal Content of Some Benthic Species from Coastal Waters of the Florida Panhandle using High-Resolution Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Analysis. Archives of Environmental Contamination and Toxicology 44: 218-223.



LI, S.S.C.

Li, C., C. Iosef, C.Y.H. Jia, V.K.M. Han, and S.S.C. Li. 2003. Dual Functional Roles for the X-Linked Lymphoproliferative Syndrome Gene Product SAP/SH2D1A in Signaling through the Signaling Lymphocyte Activation Molecule (SLAM) Family of Immune Receptors. The Journal of Biological Chemistry 278: 3852-3859.

Liu, Q., D. Berry, P. Nash, T. Pawson, C.J. McGlade, and S.S.C. Li. 2003. Structural Basis for Specific Binding of the Gads SH3 Domain to an RxxK Motif-Containing SLP-76 Peptide: A novel Mode of Peptide Recognition. Molecular Cell 11: 471-481.



LITCHFIELD, D.W.

Donella-Deana, A., L. Cesaro, S. Sarno, M. Ruzzene, A.M. Brunati, O. Marin, G. Vilk, A. Doherty-Kirby, G. Lajoie, D.W. Litchfield, and L.A. Pinna. 2003. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochemical Journal 372: 841-849.

Litchfield, D.W. 2003. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. Biochemical Journal 369: 1-15.

Sun, J.M., H.Y. Chen, M. Moniwa, D.W. Litchfield, E. Seto, and J.R. Davie. 2002. The Transcriptional Repressor Sp3 Is Associated with CK2-phosphorylated Histone Deacetylase 2. The Journal of Biological Chemistry 277 (39): 35783-35786.



MEAKIN, S.O.

Liu, H.Y., and S.O. Meakin. 2002. ShcB and ShcC Activation by the Trk Family of Receptor Tyrosine Kinases. The Journal of Biological Chemistry 277: 26046-26056.

Ranzi, V., S.O. Meakin, C. Miranda, P. Mondellini, M.A. Pierotti, and A. Greco. 2003. The Signaling Adapters Fibroblast Growth Factor Receptor Substrate 2 and 3 Are Activated by the Thyroid TRK Oncoproteins. Endocrinology 144 (3): 922-928.

Zhou, L., K. McDougall, C.J. Kubu, J.M. Verdi, and S.O. Meakin. 2003. Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes. Molecular Biology Reports 30: 15-25.



PETERSEN, N.O.

Harbottle, R.R., K. Nag, N.S. McIntyre, F. Possmayer, and N.O. Peterson. 2003. Molecular Organization Revealed by Time-of-Flight Secondary Ion Mass Spectrometry of a Clinically Used Extracted Pulmonary Surfactant. Langmuir 19: 3698-3704.

Lee, C.C., M. Revington, S.D. Dunn, and N.O. Petersen. 2003. The Lateral Diffusion of Selectively Aggregated Peptides in Giant Unilamellar Vesicles. Biophysical Journal 84: 1756-1764.



PICKERING, J.G.

Karkanis, T., S. Li, J.G. Pickering, and S.M. Sims. 2003. Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery. American Journal of Physiology. Heart and Circulatory Physiology. 284: H2325-H2334.

Rocnik, E.F., E. van der Veer, H. Cao, R.A. Hegele, and J.G. Pickering. 2002. Functional Linkage between the Endoplascic Reticulum Protein Hsp47 and Procollagen Expression in Human Vascular Smooth Muscle Cells. The Journal of Biological Chemistry 277: 38571-38578.



POSSMAYER, F.

Capote, K.R., F.X. McCormack, and F. Possmayer. 2003. Pulmonary Surfactant Protein-A (SP-A) Restores the Surface Properties of Surfactant after Oxidation by a Mechanism That Requires the Cys6 Interchain Disulfide Bond and the Phospholipid Binding Domain. The Journal of Biological Chemistry 278 (23): 20461-20474.

Harbottle, R.R., K. Nag, N.S. McIntyre, F. Possmayer, and N.O. Peterson. 2003. Molecular Organization Revealed by Time-of-Flight Secondary Ion Mass Spectrometry of a Clinically Used Extracted Pulmonary Surfactant. Langmuir 19: 3698-3704.

Nanjundan, M., and F. Possmayer. 2003. Pulmonary phosphatidic acid phosphatase and lipid phosphate phosphohydrolase. American Journal of Physiology. Lung Cellular and Molecular Physiology 284: L1-L23.

Yu, S.H., and F. Possmayer. 2003. Lipid compositional analysis of pulmonary surfactant monolayers and monolayer-associated reservoirs. Journal of Lipid Research 44 (3): 621-629.



SHAW, G.S.

McClintock, K.A., and G.S. Shaw. 2003. A Novel S100 Target Conformation Is Revealed by the Solution Structure of the Ca2+-S100B-TRTK-12 Complex. The Journal of Biological Chemistry 278: 6251-6257.

Merkley, N., and G.S. Shaw. 2003. Interaction of the tail with the catalytic region of a class II E2 conjugating enzyme. Journal of Biomolecular NMR 26: 147-155.



SHILTON, B.H.

Shilton, B.H. 2003. Small-Angle X-Ray Scattering Studies of Membrane Transporter Peripheral Components and Soluble Domains. Membrane Transporters: Methods and Protocols. 227. Q. Yan. Methods in Molecular Biology 227. Totowa, NJ: Humana Press Inc. 281-306.

Shilton, B.H., J.H. McDowell, W.C. Smith, and P.A. Hargrave. 2002. The solution structure and activation of visual arrestin studied by small-angle X-ray scattering. European Journal of Biochemistry 269: 3801-3809.



SIU, V.M.

Bhayana, S., V.M. Siu, G.I. Joubert, C.L. Clarson, H. Cao, and R.A. Hegele. 2002. Cardiomyopathy in congenital complete lipodystrophy. Clinical Genetics 61: 283-287.

Takhar, J., A.K. Malla, V. Siu, C. MacPherson, Y.S. Fan, and L. Townsend. 2002. An interstitial deletion of the long arm of chromosome 21 in a case of a first episode of psychosis. Acta Psychiatrica Scandinavica 106: 71-75.



SKERJANC, I.S.

Rogerson, P.J., M. Jamali, and I.S. Skerjanc. 2002. The C-terminus of myogenin, but not MyoD, targets upregulation of MEF2C expression. Federation of European Biochemical Societies 524: 134-138.



TREVITHICK, J.R.

Bantseev, V., D. McCanna, A. Banh, W.W. Wong, K.L. Moran, D.G. Dixon, J.R. Trevithick, and J.G. Sivak. 2003. Mechanisms of Ocular Toxicity Using the in Vitro Bovine Lens and Sodium Dodecyl Sulfate as a Chemical Model. Toxicological Sciences 73: 98-107.

Wahlman, J., M. Hirst, J.E. Roberts, C.D. Prickett, and J.R. Trevithick. 2003. Focal Length Variability and Protein Leakage as Tools for Measuring Photooxidative Damage to the Lens. Photochemistry and Photobiology 78 (1): 88-92.



YEE, S.P.

Feng, Q., W. Song, X. Lu, J.A. Hamilton, M. Lei, T. Peng, and S.P. Yee. 2002. Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase. Circulation 106: 873-879.

Qutob, M.S., R.N. Bhattacharjee, E. Pollari, S.P. Yee, and J. Torchia. 2002. Microtubule-Dependent Subcellular Redistribution of the Transcriptional Coactivator p/CIP. Molecular and Cellular Biology 22 (18): 6611-6626.



YEUNG, K.K.C.

Yeung, K.K.C., K.K. Atwal, and H. Zhang. 2003. Dynamic capillary coatings with zwitterionic surfactants for capillary isoelectric focusing. The Analyst 128: 566-570.