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Leaders in Learning: Publications of Faculty & Staff

Biochemistry 2001-2002

BEHME, M.T.

Behme, M.T., J.L. Mahon, and J. Dupre. 2002. Autoantibodies and HLA susceptibility markers in Canadian first degree relatives of patients with type 1 diabetes. Immunology of Diabetes Autoimmune Mechanisms and the Prevention and cure of Type 1 Diabetes. 958. C.B. Sanjeevi. New York: The New York Academy of Sciences. 228-231.

BRANDL, C.J.

Ricci, A.R., J. Genereaux, and C. Brandl. 2002. Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium. Molecular and Cellular Biology 22 (12): 4033-4042.

Turner, S.D., A.R. Ricci, H. Petropoulos, J. Genereaux, I.S. Skerjanc, and C.J. Brandl. 2002. The E2 ubiquitin conjugase Rad6 is required for the ArgR/Mcm1 repression of ARG1 transcription. Molecular and Cellular Biology 22 (12): 4011-4019.

CHACONAS, G.

Chaconas, G., and R.M. Harshey. 2002. Transposition of Phage Mu DNA (Chapter 17). Mobile DNA II. N.L. Craig, R. Craigie, M. Gellert, and A.M. Lambowitz. Washington, DC, USA: American Society for Microbiology. 384-396.

Kobryn, K., and G. Chaconas. 2001. The circle is broken: Telomere resolution in linear replicons. Current Opinion in Microbiology 4: 558-564.

Kobryn, K., and G. Chaconas. 2002. ResT, a telomere resolvase encoded by the Lyme disease spirochete. Molecular Cell 9: 195-201.

DUNN, S.D.

Cipriano, D.J., Y. Bi, and S.D. Dunn. 2002. Genetic fusions of globular proteins to the e subunit of the Escherichia coli ATP synthase. The Journal of Biological Chemistry 277 (19): 16782-16790.

Del Rizzo, P.A., Y. Bi, S.D. Dunn, and B.H. Shilton. 2002. The "second stalk" of Escherichia coli ATP synthase: Structure of the isolated dimerization domain. Biochemistry 41: 6875-6884.

Dempsey, B.R., A. Economou, S.D. Dunn, and B.H. Shilton. 2002. The ATPase domain of SecA can form a tetramer in solution. Journal of Molecular Biology 315: 831-843.

Revington, M., S.D. Dunn, and G.S. Shaw. 2002. Folding and stability of the b subunit of the F₁F₀ ATP synthase. Protein Science 11: 1227-1238.

GRANT, C.W.M.

Sharpe, S., K.R. Barber, and C.W.M. Grant. 2002. Evidence of a tendency to self-association of the transmembrane domain of ErbB-2 in fluid phospholipid bilayers. Biochemistry 41: 2341-2352.

Sharpe, S., K.R. Barber, and C.W.M. Grant. 2002. Interaction between ErbB-1 and ErbB-2 transmembrane domains in bilayer membranes. FEBS Letters 519: 103-107.

Sharpe, S., K.R. Barber, C.W.M. Grant, D. Goodyear, and M.R. Morrow. 2002. Organization of model helical peptides in lipid bilayers: Insight into the behavior of single-span protein transmembrane domains. Biophysical Journal 83: 345-358.

Sharpe, S., C.W.M. Grant, K.R. Barber, J. Giusti, and M.R. Morrow. 2001. Structural implications of a Val —> Glu mutation in transmembrane peptides from the EGF receptor. Biophysical Journal 81: 3231-3239.

HANIFORD, D.B.

Allingham, J.S., and D.B. Haniford. 2002. Mechanisms of metal ion action in Tn10 transposition. Journal of Molecular Biology 319: 53-65.

Haniford, D.B. 2002. Transposon Tn10 (Chapter 20). Mobile DNA II. N.L. Craig, R. Craigie, M. Gellert, and A.M. Lambowitz. Washington, DC, USA: American Society for Microbiology. 457-482.

HEGELE, R.A.

Al-Shali, K., J. Wang, F. Fellows, M.W. Huff, B.M. Wolfe, and R.A. Hegele. 2002. Successful pregnancy outcome in a patient with severe chylomicronemia due to compound heterozygosity for mutant lipoprotein lipase. Clinical Biochemistry 35: 125-130.

Argmann, C.A., C.H. Van Den Diepstraten, C.G. Sawyez, J.Y. Edwards, R.A. Hegele, B.M. Wolfe, and M.H. Huff. 2001. Transforming growth factor-ß1 inhibits macrophage cholesteryl ester accumulation induced by native and oxidized VLDL remnants. Arteriosclerosis Thrombosis and Vascular Biology 21: 2011-2018.

Busch, C.P., and R.A. Hegele. 2001. Genetic determinants of type 2 diabetes mellitus. Clinical Genetics 60: 243-254.

Cao, H., and R.A. Hegele. 2001. Single nucleotide polymorphisms of the resistin (RSTN) gene. Journal of Human Genetics 46: 553-555.

Hanley, A.J.G., G. McKeown-Eyssen, S.B. Harris, and R.A. Hegele. 2001. Cross-sectional and prospective association between proinsulin and cardiovascular disease risk factors in a population experiencing rapid cultural transition. Diabetes Care 24 (7): 1240-1247.

Hegele, R.A. 2002. ABC transporters and cholesterol absortion. Lipids 13: 467-470.

Hegele, R.A. 2002. Candidate genes and molecules. Wiley Encyclopedia of Molecular Medicine. 5. H.H. Kazazian. New York: Wiley, John & Sons. 445-446.

Hegele, R.A. 2001. Genes, environment and diabetes in Canadian aboriginal communities. Diabetes and Cardiovascular Disease: Etiology, Treatment, and Outcomes. A. Angel, N.S. Dhalla, and G.N. Pierce. New York: Kluwer Academic/Plenum Publishers. 11-20.

Hegele, R.A. 2001. Monogenic dyslipidemias: Window on determinants of plasma lipoprotein metabolism. The American Journal of Human Genetics 69 (6): 1161-1177.

Hegele, R.A., M.R. Ban, and T.K. Young. 2001. Serum C-reactive protein in Canadian Inuit and its association with genetic variation on chromosome 1q21. Clinical Chemistry 47 (9): 1707-1709.

Hegele, R.A., S.B. Harris, B. Zinman, A.J.G. Hanley, and H. Cao. 2001. Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphisms in Oji-Creee. Diabetes Care 24 (8): 1498-1499.

Mok, A., H. Cao, B. Zinman, A.J.G. Hanley, S.B. Harris, B.P. Kennedy, and R.A. Hegele. 2002. A single nucleotide polymorphism in protein tyrosine phosphatase PTP-1B is associated with protection from diabetes or impaired glucose tolerance in Oji-Cree. The Journal of Endocrinology & Metabolism 87 (2): 724-727.

Near, S.E., J. Wang, and R.A. Hegele. 2001. Single nucleotide polymorphisms of the very low density lipoprotein receptor (VLDLR) gene. Journal of Human Genetics 46: 490-493.

Rosset, J., J. Wang, B.M. Wolfe, P.J. Dolphin, and R.A. Hegele. 2001. Lecithin: cholesterol acyl transferase G30S: Association with atherosclerosis, hypoalphalipoproteinemia and reduced in vivo enzyme activity. Clinical Biochemistry 34: 381-386.

Triggs-Raine, B.L., R.D. Kirkpatrick, S.L. Kelly, L.D. Norquayk, P.A. Cattini, K. Yamagata, A.J.G. Hanley, B. Zinman, S.B. Harris, P.H. Barrett, and R.A. Hegele. 2002. HNF-1a G319S, a transactivation-deficient mutant, is associated with altered dynamics of diabetes onset in an Oji-Cree community. PNAS Early Edition : 1-6.

Wang, J., E. Huff, L. Janecka, and R.A. Hegele. 2001. Low density lipoprotein receptor (LDLR) gene mutations in Canadian subjects with familial hypercholesterolemia, but not of French descent. Human Mutation 18 (4): 359.

Wang, J., S. Near, K. Young, P.W. Connely, and R.A. Hegele. 2001. ABCC6 gene polymorphism associated with variation in plasma lipoproteins. Journal of Human Genetics 46: 699-705.

HOWARD, J.C.

Gan, B.S., J. Kim, G. Reid, P. Cadieux, and J.C. Howard. 2002. Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats. The Journal of Infectious Diseases 185: 1369-1372.

Howard, J.C., Q. Li, W. Chu, B. Zochodne, M. Kapoor, Y. Ung, K. Rosen, and Y. Ben-David. 2001. Bcl-2 expression in F-MuLV-induced erythroleukemias: a role for the anti-apoptotic action of Bcl-2 during tumor progression. Oncogene 20: 2291-2300.

Reid, G., B.S. Gan, Y. She, W. Ens, S. Weinberger, and J.C. Howard. 2002. Rapid identification of probiotic lactobacillus biosurfactant proteins by ProteinChip tandem mass spectrometry tryptic peptide sequencing. Applied and Environmental Microbiology 68 (2): 977-980.

Reid, G., J. Howard, and B.S. Gan. 2001. Can bacterial interference prevent infection? Trends in Microbiology 9 (9): 424-425.

HUFF, M.H.

JUNG, J.H.

Fan, Y.S., Y. Zhang, M. Speevak, S. Farrell, J.H. Jung, and V.M. Siu. 2001. Detection of subtelomeric aberrations in patients with unexplained mental retardation and. Genetics in Medicine 3 (6): 416-421.

KONERMANN, L.

Konermann, L., Silva E.A., and O.F. Sogbein. 2001. Electrochemically induced pH changes resulting in protein unfolding in the ion source of an electrospray mass spectrometer. Analytical Chemistry 73 (20): 4836-4844.

Simmons, D.A., and L. Konermann. 2002. Characterization of transient protein folding intermediates during myoglobin reconstitution by time-resolved electrospray mass spectrometry with on-line isotopic pulse labeling. Biochemistry 41 (6): 1906-1914.

LI, S.

Hwang, P.M., C. Li, M. Morra, J. Lillywhite, D.R. Muhandiram, F. Gertler, C. Terhorst, L.E. Kay, T. Pawson, J.D. Forman-Kay, and S. Li. 2002. A 'three-pronged' binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. The EMBO Journal 21 (3): 314-323.

Morra, M., M. Simarro-Grande, M. Martin, A.S. Chen, A. Lanyi, O. Silander, S. Calpe, J. Davis, T. Pawson, M.J. Eck, J. Sumegi, P. Engel, S. Li, and C. Terhorst. 2001. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. The Journal of Biological Chemistry 276 (39): 36809-36816.

LITCHFIELD, D.W.

Canton, D.A., C. Zhang, and D.W. Litchfield. 2001. Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2ß. Biochemical Journal 358: 87-94.

Hanawa, H., Y. Ma, S.A. Mikolajczak, M.L. Charles, T. Yoshida, R. Yoshida, C.A. Strathdee, D.W. Litchfield, and A. Ochi. 2002. A novel constimulatory signaling in human T lymphocytes by a splice variant of CD28. Blood 99 (6): 2138-2145.

Litchfield, D.W., D.G. Bosc, D.A. Canton, R.B. Saulnier, G. Vilk, and C. Zhang. 2001. Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners. Molecular and Cellular Biochemistry 227: 21-29.

Messenger, M.M., R.B. Saulnier, A.D. Gilchrist, P. Diamond, G.J. Gorbsky, and D.W. Litchfield. 2002. Interactions between protein kinase CK2 and Pin1. The Journal of Biological Chemistry 277 (25): 23054-23064.

Vilk, G., D.R. Derksen, and D.W. Litchfield. 2002. Inducible expression of the regulatory protein kinase CK2ß subunit: Incorporation into complexes with catalytic CK2 subunits and re-examination of the effects of CK2ß on cell proliferation. Journal of Cellular Biochemistry : 84-99.

Zhang, C., G. Vilk, D.A. Canton, and D.W. Litchfield. 2002. Phosphorylation regulates the stability of the regulatory CK2ß subunit. Oncogene 21 (23): 3754-3764.

PICKERING, J.G.

Chow, L.H., D.R. Boughner, J. Dunmore-Buyze, H. Finlay, and J.G. Pickering. 2001. Enhanced detection of cardiac myocyte damage by polarized light microscopy: Use in a model of coxsackievirus B3-induced myocarditis. Cardiovascular Pathology 10: 83-86.

Li, S., Y. Fan, L.H. Chow, C. Van Den Diepstraten, E. van der Veer, S.M. Sims, and J.G. Pickering. 2001. Innate diversity of adult human arterial smooth muscle cells, cloning of distinct subtypes from the internal thoracic artery. Circulation Research 89: 517-525.

POSSMAYER, F.

Maitra, G., K. Inchley, R.J. Novick, R.A.W. Veldhuizen, J.F. Lewis, and F. Possmayer. 2002. Acute lung injury and lung transplantation influence in vitro subtype conversion of pulmonary. American Journal of Physiology - Lung Cellular and Molecular Physiology 282: L67-L74.

Nag, K., J.S. Pao, R.R. Harbottle, F. Possmayer, N.O. Petersen, and L.A. Bagatolli. 2002. Segregation of saturated chain lipids in pulmonary surfactant films and bilayers. Biophysical Journal 82: 2041-2051.

Nanjundan, M., and F. Possmayer. 2001. Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases. American Journal of Physiology - Lung Cellular and Molecular Physiology 281: L1484-L1493.

Nanjundan, M., and F. Possmayer. 2001. Pulmonary lipid phosphate phosphohydroase in plasma membrane signalling platforms. Biochemical Journal 358: 637-646.

Veldhuizen, R.A.W., B. Welk, R. Harbottle, S. Hearn, K. Nag, N. Petersen, and F. Possmayer. 2002. Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant. Journal of Applied Physiology 92 (3): 1169-1175.

Yu, S., and F. Possmayer. 2001. Dipalmitoylphosphatidylcholine and cholesterol in monolayers spread from adsorbed films of pulmonary surfactant. Journal of Lipid Research 42: 1421-1429.

SHAW, G.S.

Ferguson, P.L., and G.S. Shaw. 2002. Role of the N-terminal helix I for dimerization and stability of the calcium-binding protein S100B. Biochemistry 41 (11): 3637-3646.

Hamilton, K.S., M.J. Ellison, K.R. Barber, R.S. Williams, J.T. Huzil, S. McKenna, C. Ptak, M. Glover, and G.S. Shaw. 2001. Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin Tail. Structure 9: 897-904.

McClintock, K.A., L.J. Van Eldik, and G.S. Shaw. 2002. The C-terminus and linker region of S100B expert dual control on protein-protein interactions with TRTK-12. Biochemistry 41 (17): 5421-5428.

Revington, M., S.D. Dunn, and G.S. Shaw. 2002. Folding and stability of the b subunit of the F₁F₀ ATP synthase. Protein Science 11: 1227-1238.

SHILTON, B.H.

Del Rizzo, P.A., Y. Bi, S.D. Dunn, and B.H. Shilton. 2002. The "second stalk" of Escherichia coli ATP synthase: Structure of the isolated dimerization domain. Biochemistry 41: 6875-6884.

Dempsey, B.R., A. Economou, S.D. Dunn, and B.H. Shilton. 2002. The ATPase domain of SecA can form a tetramer in solution. Journal of Molecular Biology 315: 831-843.

Seet, B.T., J. Barrett, J. Robichaud, B. Shilton, R. Singh, and G. McFadden. 2001. Glycosaminoglycan binding properties of the myxoma virus CC-chemokine inhibitor, M-T1. Journal of Biological Chemistry 276 (32): 30504-30513.

SIU, V.M.

SKERJANC, I.S.

Jamali, M., C. Karamboulas, P.J. Rogerson, and I.S. Skerjanc. 2001. BMP signaling regulates Nkx2-5 activity during cardiomyogenesis. Federation of European Biochemical Societies 509: 126-130.

Jamali, M., P.J. Rogerson, S. Wilton, and I.S. Skerjanc. 2001. Nkx2-5 activity is essential for cardiomyogenesis. The Journal of Biological Chemistry 276 (45): 42252-42258.

Petropoulos, H., and I. Skerjanc. 2002. ß-catenin is essential and sufficient for skeletal myogenesis in P19 cells. The Journal of Biological Chemistry 277 (18): 15393-15399.

TURLEY, E.A.

Hall, C.L., L.A. Collis, J.B. A, L. Lange, A. McNicol, J.M. Gerrard, and E.A. Turley. 2001. Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion. Matrix Biology 20: 183-192.

Harrison, R.E., and E.A. Turley. 2001. Active erk regulates microtubule stability in H-ras-transformed cells. Neoplasia 3 (5): 385-394.

Lynn, B.D., X. Li, P.A. Cattini, E.A. Turley, and J.I. Nagy. 2001. Identification of sequence, protein isoforms, and distribution of the hyaluronan-binding protein RHAMM in adult and developing rat brain. The Journal of Comparative Neurology 439: 315-330.

Lynn, B.D., E.A. Turley, and J.I. Nagy. 2001. Subcellular distribution, calmodulin interaction, and mitochondrial association of the hyaluronan-binding protein RHAMM in rat brain. Journal of Neuroscience Research 65: 6-16.

Turley, E.A. 2001. Extracellular matrix remodeling multiple paradigms in vascular disease. Circulation Research 88: 2-4.

Ziebell, M.R., Z. Zhao, B. Luo, Y. Luo, E.A. Turley, and G.D. Prestwich. 2001. Peptides that mimic glycosaminoglycans: high-affinity ligands for a hyaluronan binding domain. Chemistry & Biology 8: 1081-1094.

WOLFE, B.M.

YEUNG, K.K.C.

Yeung, K.K.C., A.G. Kiceniuk, and L. Li. 2001. Capillary electrophoresis using a surfactant-treated capillary coupled with offline matrix-assisted laser desorption ionization mass spectrometry for high efficiency and sensitivity detection of proteins. Journal of Chromatography A 931: 153-162.