Maged Goubran, Cathie Crukley, Sandrine de Ribaupierre, Terence M. Peters, Ali R. Khan If you have a recent publication that you wish to promote please contact Janelle Cobban in Graduate & Postdoctoral Affairs.
Postdoctoral Publication of the Week
Dr. Ali Khan
Significance of the Research:
Up to 30% of patients with epilepsy don't have control of seizures with drugs, and in these cases surgical treatment is often required. Planning for these surgerites can be extremely challenging and histopathological validation of new MRI sequences and analysis techniques can improve localization of subtle lesions and potentially lead to less invasive surgical treatment.
This work presents a novel pipeline for aligning MRI and histology of hippocampal and temporal lobe neocortical sections from epilepsy surgery, and presents a validation protocol to assess the accuracy and reliability of our registration protocol. This work enables the comparison of histology and imaging and can thus lead to better localization of seizure zones and tailored approaches for epilepsy surgery.
Image registration of ex-vivo MRI to sparsely sectioned histology of hippocampal and neocortical temporal lobe specimens
NeuroImage, Volume 83, December 2013, Pages 770-781
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Maged Goubran, Cathie Crukley, Sandrine de Ribaupierre, Terence M. Peters, Ali R. Khan
If you have a recent publication that you wish to promote please contact Janelle Cobban in Graduate & Postdoctoral Affairs.
T (519) 661-3459
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