University of Western Ontario
Chronic diabetic complications are the main research focus in this laboratory. Hyperglycemia is the key initiating factor in the pathogenesis of chronic diabetic complications. Several secondary and tertiary biochemical mechanisms may be triggered as a result of sustained hyperglycemia. These mechanisms may in turn modulate several proteins which may be of importance in chronic diabetic complications. Mechanisms of several of these chronic diabetic complications are being investigated in an attempt to identify potential treatment targets. Diabetic retinopathy and cardiomyopathy are two major areas of research in our laboratory. Current projects involve analysis of various mechanisms involved in the regulation of vasoactive factor and extracellular matrix protein gene expression and correlation of such changes with the structural changes in the retina and the heart. We investigate several putative signaling mechansims of microvascular injury using cell culture, animal experiments and in human tissues. The investigations also involve glucose induced DNA damage, alterations of histone acetylation, deacetylation and miRNA We are also involved in several multi-disciplinary research groups. As a part of the Ontario ginseng innovation research consortium (OGIRC), we are involved in the investigation of the potential preventive role of ginseng in chronic diabetic complications. Through our collaboration we are involved in the investigation of various mechanistic aspects of heart failure, its causes, pathogenesis and treatment..
|Platform Technology Group:||Pre-Clinical|
|Research Keywords:||Chronic Diabetic Complications, Diabetic Retinopathy, Diabetic Cardiomyopathy, Vasoactive Factors, Extracellular Matrix Proteins, Angiogenesis, Epigenetics|
|Personal web page:||http://publish.uwo.ca/~schakrab/
|Research Projects:||Effect of ginseng on biochemical, functional and structural changes in kidney and retina of mouse model of Type1 and Type 2 diabetes.|