Kaiping Yang
Professor
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PH.D. University of Nottingham |
Areas of research interests include (1) Glucocorticoid actions and metabolism in pregnancy/fetal development; (2) Glucocorticoid actions and metabolism in obesity and its associated metabolic disorders; (3) Molecular basis of intrauterine growth restriction; (4) Fetal origins of visceral obesity; and (5) Effects of environmental pollutants/toxins on placental function and fetal development. Both in vivo (animal models) and in vitro (cell cultures and human tissues) as well as classic physiological/biochemical and modern molecular, proteomics and functional genomics approaches/techniques are being utilized.
Yang K, Julan L, Rubio F, Sharma A & Guan H (2006). Cadmium reduces 11B-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells. Am J Physiol Endocrinol Metab 290(1):E135-E142. Julan L, Guan H, van Beek JP & Yang K (2005). PPAR? suppresses 11B-hydroxysteroid dehydrogenase type 2 gene expression in human placental trophoblast cells. Endocrinology 146, 1482-1490. Guan H, Arany E, van Beek JP, Chamson-Reg A, Thyssen S, Hill DJ & Yang K (2005). Adipose tissue gene expression profiling reveals distinct molecular pathways that define visceral adiposity in the offspring of maternal protein restricted rats. Am J Physiol Endocrinol Metab 288, E663¨CE673. Guan H, Dy J, Richardson B & Yang K (2005). Identification of two novel allelic variants of ESX1L in the human placenta: lack of an association with intrauterine growth restriction. Placenta 26, 766-772. Yang K (1997). Placental 11B-hydroxysteroid dehydrogenase: barrier to maternal glucocorticoids. Reviews of Reproduction 2(3), 129-132.
