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PH.D. University of Toronto |
Research in my laboratory is aimed at elucidating nuclear pathways controlling gene expression and genome stability. Our long-term goal is to understand how malfunction of specific regulatory pathways contributes to cellular transformation and oncogenesis. Please visit my personal webpage for more information about my research and laboratory.
Mohan, R., Rao, A., Gagliardi, J. and Tini, M. (2006). SUMO-dependent allosteric regulation of Thymine DNA Glycosylase alters subnuclear localization and CBP/p300 recruitment. Molecular and Cellular Biology (Epub ahead of print). Naeem,H., Underhill, C., Zao, E., Tini, M., Bedford, M. and J. Torchia (2006). Negative regulation of transcription by the arginine methyltransferase CARM-1. Molecular and Cellular Biology (Epub ahead of print). Tini, M., Benecke, A., Um, S.-J., Torchia, J., Evans, R. M., and P., Chambon (2002). Association of CBP/300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol. Cell. 9: 265-277 (* corresponding author) Xu, W., Chen, H., Du, K., Asahara, H., Tini, M., Emerson, B. M., Montminy, M., and R. M., Evans (2001) A transcriptional switch mediated by co-factor methylation. Science 294: 2507-2511 Doucas, V., Tini, M., Egan, D. A. and Evans, R. M. (1998). Modulation of CBP function by promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling. Proc. Natl. Acad. Sci 96: 2627-2632 Voegel, J. J., Heine, M. J. S., Tini, M., Vivat, V., Chambon, P., and H., Gronemeyer (1997). The coactivator TIF2 contains three nuclear receptor binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. EMBO J. 17: 507-519
