L. Stan Leung
Professor
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PH.D. University of California, Berkeley |
1. Seizures and physiological consequences. Various models of temporal lobe epilepsy (kindling, kainic acid, pilocarpine) and immature animal seizures (hyperthermia, convulsants) are used. The physiological consequences of acute and chronic seizure activity are studied. Changes in neural circuits are studied in vivo using 16-channel electrodes, field potential recordings, and current source density analysis. Changes in synaptic properties are studied in vitro using intracellular and whole-cell recordings from brain slices.
2. Behavioral alterations after seizures. Behavioral consequences of experimental seizures are studied using a variety of cognitive (spatial maze) and motor (prepulse inhibition, activity rhythms) tasks. Physiology of neuronal populations using current source density analysis. We pioneer novel techniques of field potential analysis of dendritic potentials and its modulation by subcortical input, cholinergic and GABA-B receptor agonists and antagonists.
Leung LS (1998) Generation of theta and gamma rhythms in the hippocampus. Neuroscience Biobehavioral Reviews 22: 275-290. Leung LS, Ma J and McLachlan RS (2000) Behaviors induced or disrupted by complex partial seizures. Neuroscience BioBehavioral Reviews 24: 763-775. Tsai ML and Leung LS (2006). Decrease of hippocampal GABAB-receptor mediated inhibition after hyperthermia-induced seizures in immature rats. Epilepsia 47:277-287.
