Gerald Kidder

Professor

Gerald Kidder

PH.D. Yale University
B.Sc. Hiram College
Office:  Dental Science Building 00061B
Phone: (519) 661-2111 Ext. 8313
Fax: (519) 661-3827 or (519) 850-2562
E-mail: gerald.kidder@schulich.uwo.ca
See Publications by Gerald Kidder on PubMed

Research in the Kidder lab is aimed at understanding the roles of intercellular communication in mammalian gametogenesis. We are interested in the direct exchange of molecules via gap junction channels as well as signaling via secreted paracrine factors, and the interaction between these two communication pathways. We use a range of approaches in cellular and molecular biology and genetics to study the development of gametes and preimplantation embryos of the mouse. We also model human connexin mutations in mice to study their effects on reproductive and other organs. The knowledge gained is used in the clinic to improve the outcome of infertility treatment.

Kidder, G.M. and Vanderhyden, B.C.  (2010).  Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence. Can. J. Physiol. Pharmacol. 88: 399-413.

Wang, H.-X., Li, T.Y., and Kidder, G.M. (2010). WNT2 regulates DNA synthesis in mouse granulosa cells through β-catenin. Biol. Reprod. 82: 865-875.

Wang, H.-X., Tong, D., El-Gehani, F., Tekpetey, F.R., and Kidder, G.M. (2009). Connexin expression and gap junctional coupling in human cumulus cells: contribution to embryo quality. J. Cell. Molec. Med. 13: 972-984.

Tong, D., Lu, X., Wang, H.-X., Plante, I., Lui, E., Laird, D.W., Bai, D., and Kidder, G.M. (2009). A dominant loss-of-function Gja1 (Cx43) mutant impairs parturition in the mouse. Biol. Reprod. 80: 1099-1106. 

Tong, D., Colley, D., Thoo, R., Li, T.Y., Plante, I., Laird, D.W., Bai, D., and Kidder, G.M. (2009). Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia. Dis. Model. Mech. 2: 157-167.

Li, T.Y., Colley, D., Barr, K.J., Yee, S.-P., and Kidder, G.M.  (2007). Rescue of oogenesis in Cx37 null mutant mice by oocyte-specific replacement with Cx43.  J. Cell Sci. 120: 4117-4125.

Tong, D., Li, T.Y., Naus, K.E., Bai, D., and Kidder, G.M. (2007). In vivo analysis of undocked connexin43 gap junction hemichannels in ovarian granulosa cells. J. Cell Sci.120: 4016-4024.

Kahiri, C.N., Khalil, M.W., Tekpetey, F., and Kidder, G.M. (2006). Leydig cell function in mice lacking connexin43. Reproduction 132: 607-616.

Gittens, J.E. I, Barr, K. J., Vanderhyden, B.C., and Kidder, G. M. (2005). Interplay between paracrine signalling and gap junctional communication in ovarian follicles. J. Cell Sci. 118: 113-122.




Innovation and Excellence in Research and Teaching