Douglas Jones
Professor
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Associate Dean Basic Medical Sciences Academic Affairs |
My research focuses on determining physiology and pathophysiology of cardiovascular function. Recent studies have focussed on substrates associated with arrhythmia in atrial fibrillation, mechanisms of, and development of procedures and tools for minimally-invasive, robotically-assisted cardiac surgery, and neurophysiological regulatory mechanisms of cardiovascular control. These studies have determined the role of tissue, cellular and subcellular altered ionic basis of electrical instability in arrhythmia, and gap junction alterations. In addition, there is an apparent regional disparity rendering the left atrium as the "driving" area for the induction and maintenance of atrial fibrillation - the tissue and cellular basis of this regional difference is unknown. A major contributor to the induction and maintenance of atrial arrhythmia is due to altered autonomic function. Studies involving transgenic and knock-out mouse models have been utilized to determine the signalling pathways involved in this regulation. Additional studies have involved the development of novel surgical procedures for arrhythmia therapy: we have been investigating optimization of novel surgical approaches which are applicable to minimally invasive robot-assisted surgery.
Tuomi, J. M., Chidiac, P. and Jones, D. L. Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2 deficient mouse. Am. J. Physiol. (Heart Circ. Physiol.) 298(2): H554-H561, 2010. Trevino, R. J., Jones, D. L., Porterfield, J., Kottam, A., Chisolm, G., Escobedo, D., Barton, A. and Feldman, M. D. Validation of a New Micro-Manometer Pressure Sensor for Cardiovascular Measurements in Mice. Biomed. Instrum. Technol. 44(1): 75-83, 2010. Guiraudon, G. M., Jones, D. L., Bainbridge, D., Linte, C., Pace, D., Moore, J., Wedlake, W., Lang, P., and Peters. T. M. Augmented reality image guidance during off-pump mitral valve replacement through the Guiraudon University Cardiac Introducer. Annals Surg. 5(6): 430-438, 2010. Tuomi, J. M. Voorbraak, F., Jones, D. L. and Ruijter, J. M. Bias in the Cq value observed with hydrolysis probe based quantitative PCR can be corrected with the estimated PCR efficiency value. Methods 50: 313-322, 2010. Jones, D. L. and Zhou, Z. Calcium Signalling: Introduction. Can J. Physiol. Pharmacol. 88(2):iv-viii, 2010. Thibodeau, I., Li, Q., Liu, G., Lam, K. Veinot, J.P., Green, M. S., Birnie, D. H., Jones, D. L., Krahn, A. D., Lemery, R. and Gollob, M. H. Paradigm of Genetic Mosaicism and Lone Atrial Fibrillation. Physiological Characterization of a Connexin 43-Deletion Mutant Identified From Atrial Tissue. Circulation 122:236-244, 2010. Jacques, F., Cardinal, R., Yin, Y., Armour, J. A., Guiraudon, G. M., Jones, D. L. and Pagé, P. spinal cord stimulation causes potentiation of right vagal nerve effects on atrial chronotropic function and repolarization in canines. J. Cardiovasc. Electrophys. 22(4):440-447, 2011. Tuomi, J. M., Tyml, K. and Jones, D. L. Atrial arrhythmia in the connexin 43 G60S mutant mouse: A model of Oculodentodigital Dysplasia. Am. J. Physiol. (Heart Circ Physiol) Am. J. Physiol. (Heart Circ Physiol) 300:H1402-1411, 2011. Peters, T. M., Guiraudon, G. M., Jones, D. L., Linte, C. A. Ultrasound guidance of cardiac interventions. Proc SPIE Medical Imaging. Orlando, FL. Paper 7964-28, 2011. McLeod, A. J., Moore, J., Guiraudon, G. M., Jones, D. L., Campbell, G. and Peters, T. M. Surgical Phantom for Beating Heart Mitral Valve Replacement. Proc. SPIE Vol. 7964, 796403-1-796403-7; doi:10.1117/12.877724, 2011. Lang, P., Chen, E. C. S., Guiraudon, G. M., Jones, D. L., Bainbridge, D., Drangova, M., Hata, N., Jain, A. and Peters, T. M. Feature-based US to CT Registration of the Aortic Root. IEEE Trans Biomed Eng. Paper 7964-51, 2011. Lang, P., Seslija, P., Bainbridge, D., Guiraudon, G. M., Jones, D. L., Chu, M., Holdsworth, D. W., Peters, T. M. Accuracy assessment of fluoroscopy-transesophageal echocardiography registration. Proc SPIE Medical Imaging. Orlando, FL. Paper 7964-70, 2011. Thakur, Y., Jones, D. L., Skanes, A. D., Yee, R. and Drangova, M. Right-side RF ablation using remote catheter navigation: experimental results in vivo. J. Cardiovasc. Electrophys. 23(1): 81-87, 2012. Lang, P., Seslija, P., Chu, M. W., Bainbridge, D., Guiraudon, G. M., Jones, D. L., Peters, T. M. US-Fluoroscopy Registration for Transcatheter Aortic Valve Implantation. IEEE Trans Biomed Eng. 59:1444-1453, 2012. McLeod, A. J., Moore, J., Lang, P., Bainbridge, D., Guiraudon, G. M., Jones, D. L., Campbell, G. and Peters, T. M. Evaluation of Mitral Valve Replacement Anchoring in a Phantom Proc. SPIE 8316, 83162Q, 2012. Guiraudon, G. M., Jones, D. L., Bainbridge, D., Cohen, L., Lecompte, Y., Hidden-Lucet, F., Frank, R. and Pavie, A. Hybrid Access Atria via the Universal Cardiac Introducer™ For Arrhythmia Ablation after Total Cavo-Pulmonary Derivation. Innovations 7(3): 217-222, 2012. Jones, D. L., Chidiac, P. and Tuomi, J. M. Role of Cholinergic Innervation and RGS2 in Atrial Arrhythmia. Front. Card. Electrophy. Vol 3, Article 239: 1-12. Online June 29, 2012 http://www.frontiersin.org/Journal/Abstract.aspx?s=132&name=cardiac_electrophysiology_&ART_DOI=10.3389/fphys.2012.00239
