Douglas Jones

Professor

Douglas Jones

Associate Dean Basic Medical Sciences Academic Affairs
PH.D.
University of Calgary
M.Sc. University of Alberta
B.Sc. University of Alberta
Office:  Medical Sciences Building Rm. 262
Phone: (519) 661-2111 Ext. 83480
Fax: (519) 661-4051
E-mail: doug.jones@schulich.uwo.ca
See Publications by Doug Jones on PubMed

My research focuses on determining physiology and pathophysiology of cardiovascular function. Recent studies have focused on substrates associated with arrhythmia in heart failure and atrial fibrillation, mechanisms of, and development of bioelectric devices for cardiac defibrillation, and neurophysiological regulatory mechanisms of cardiovascular control.

These studies have determined the role of tissue, cellular and subcellular altered ionic basis of electrical instability in heart failure and arrhythmia. These studies focus on ion handling, ion channels and gap junction alterations. In addition, there is an apparent regional disparity rendering the left atrium as the "driving" area for the induction and maintenance of atrial fibrillation - the tissue and cellular basis of this regional difference is unknown. A major contributor to the induction and maintenance of atrial arrhytymia is due to altered autonomic function. Studies involving transgenic and knock-out mouse models have been utilized to determine the signalling pathways involved in this regulation. Additional studies have involved the development of novel surgical procedures for arrhythmia therapy: we have been investigating optimization of novel surgical approaches which are applicable to minimally invasive robot-assisted surgery.

Burger, D., Lu, X., Lei, M., Xiang, F, Hammoud, L., Jiang, J., Wang, H., Jones, D. L., Sims, S. and Feng, Q.  Neuronal nitric oxide synthase protects against myocardial infarction-induced ventricular arrhythmia and mortality in mice. Circulation (In press).

Trevino, R. J., Jones, D. L., Porterfield, J., Kottam, A., Chisolm, G., Escobedo, D., Barton, A. and Feldman, M. D. Validation of a New Micro-Manometer Pressure Sensor for Cardiovascular Measurements in Mice. Biomed. Instrum. Technol. (In Press), 2009.

Jones, D. L., Guiraudon, G. M., Skanes, A. C. and Guiraudon, C. M. Anatomical Pitfalls during Encircling Cryoablation of the Left Atrium for Atrial Fibrillation in the Pig. J. Intervent. Cardiac Electrophysiol. 2008; 21: 187-193.

Jackson, P. E. M., Feng Q. and Jones D.L. iNOS-derived NO Cellular regulation of Connexin 43 in the mouse with coronary artery ligation-induced heart failure. Acta Physiol. 2008;194: 23-33.

Stanbouly, S., Kirshenbaum, L.A., Jones, D.L., and Karmazyn, M. Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expresion in cardiomyocytes via reverse mode sodium calcium exchange and JNK dependent pathways. J. Pharmacol. Exp. Therap. 2008;327(1):105-113.

Falcao, S., Rousseau, G., Baroudi, G., Vermeulen, M., Bouchard, C., Jones, D.L. and Cardinal, R. Synergistic proarrhythmic effects of reduced connexin 43 expression and excitability under metabolic stress in non-scar, failing myocardium. Pflügers Archiv-Europ J. Physiol., 2007;454: 999-1009.




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