David Hess
Assistant Professor
 |
PH.D. University of Western Ontario |
-Hematopoietic repopulating function(s) of purified stem cells from various adult sources.
-Transplantation of endothelial progenitor cells to promote angiogenesis in ischemic tissues.
-Transplantation of purified stem cells to support the regeneration of beta-cell function.
-Investigating the mechanisms by which distinct stem cell subsets co-ordinate complex biological processes including hematopoiesis, angiogenesis, and tissue regeneration.
Hess D.A., Bonde J., Craft T.P., Wirthlin L., Herrbrich P.E., DiPersio J.F., Devine S.M., Nolta J.A. Human progenitor cells rapidly mobilized by AMD3100 repopulate NOD/SCID mice with increased efficiency in comparison to cells from the same donor mobilized by granulocyte colony stimulating factor (2006) Leukemia (In press). Hess D.A., Wirthlin L., Craft T.P., Herrbrich P.E., Hohm S.A., Lahey R., Eades W.C., Creer M.H., Nolta J.A. Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells. (2006) Blood 107(5): 2162-2169. Hess D.A., Bonde J., Nolta J.A. (2004) Recent advances in hematopoietic stem cell biology. (2004) Current Opinion in Hematology 11(6): 392-398. Hess D.A., Meyerrose T.E., Wirthlin L., Craft T.P., Herrbrich P.E., Creer M.H., Nolta J.A. Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity. (2004) Blood 104(6): 1648-1655. Hess D., Li L., Martin M., Sakano S., Hill D., Strutt B., Thyssen S., Gray D.A., and Bhatia M. Bone marrow-derived stem cells initiate pancreatic regeneration. (2003) Nature Biotechnology 21(7): 763-770. Hess D.A., Karanu F.N., Levac K., Gallacher L., and Bhatia M. Co-culture and transplant of CD34+Lin- and CD34-Lin- cells reveals functional interaction between repopulating stem cells. (2003) Leukemia 17(8): 1613-1625. Hess D.A., Rosu-Myles M., White M.J., Gallacher L., Murdoch B., and Bhatia M. Functional analysis of human hematopoietic repopulating cells mobilized with G-CSF alone versus G-CSF in combination with SCF. (2002) Blood 100(3):869-878.
