Stefan Everling

Professor

Stefan Everling

(Joint Appointment with Psychology)
PH.D. University of Bremen
M.Sc. University of Bremen
B.Sc. University of Bremen
Office:  Robarts Research Institute EB-10
Phone: (519) 663-5777 Ext. 34359
Fax: (519) 663-3193
E-mail: severlin@uwo.ca
Visit: Dr. Everling's Homepage
Visit: The Brain and Mind Institute
See Publications by Stefan Everling on PubMed

Functional Organization of the Primate Prefrontal Cortex

Among the different areas of the brain, few have attracted as much attention as its anterior pole, the prefrontal cortex. Dysfunctions of the prefrontal cortex have been implicated in many psychiatric and neurological disorders, including schizophrenia, autism, and attention-deficit hyperactivity disorder. An important step toward our understanding of prefrontal dysfunction in these disorders are insights into the functional magnetic imaging (fMRI) studies, however; have yielded conflicting data and have resulted in different models of PFC organization. The main objective of this research proposal is to reconcile these conflicting results by recording fMRI signals in human subjects and fMRI signals and neural activity in the monkeys. The relationship between the fMRI signal and underlying neural activity in cognitive tasks has emerged as one of the most important areas in neuroscience. This research program will provide important insights into this relationship and will yield a better understanding of the functional organization of the prefrontal cortex. This knowledge will also be vital to predict the effects of prefrontal strokes and trauma.

 

Skoblenick KS, Everling S (2012) NMDA antagonist ketamine reduces task-selectivity in macaque dorsolateral prefrontal neurons and impairs performance of randomly interleaved pro- and anti-saccades. J. Neurosci. 32(35):12018-12027


Hutchison RMEverling S (2012) Monkey in the middle: Why nonhuman primates are needed to bridge the gap in resting-state investigations. Frontiers in Neuroanatomy 6:29. doi: 10.3389/fnana.2012.00029


Hutchison RM, Womelsdorf T, Gati JS, Leung LS, Menon RS, Everling S (2012) Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex. Cerebral Cortex 22: 1294-1308


Hutchison RM, Gallivan JP, Culham JC, Gati JS, Menon RS, Everling S (2012) Functional connectivity of the frontal eye fields in humans and monkeys investigated with resting-state fMRI. J. Neurophysiol. 107: 2463-2474.


Hutchison RM, Womelsdorf T, Gati JS, Everling S, Menon RS (2012) Resting-state networks show dynamic functional connectivity in awake humans and anesthetized macaques. Human Brain Mapping 10.1002/hbm.22058.


Kaping D, Vinck M, Everling S, Womelsdorf T (2011) Specific contributions of ventromedial frontal, anterior cingulate and lateral prefrontal cortex for attentional selection and stimulus valuation. PLOS Biology Dec;9(12):e1001224


Koval MJ, Lomber SG, Everling S (2011) Prefrontal cortex deactivation in macaques alters activity in the superior colliculus and impairs voluntary control of saccades. J. Neurosci. 31: 8659-8668


Hutchison RM, Leung LS, Mirsattaril SM, Gati JS, Menon RS, Everling S (2011) Resting-state networks in the macaque at 7 T. Neuroimage 56: 1546-1555


Phillips JM, Johnston K, Everling S (2011) Effects of anterior cingulate microstimulation on pro- and anti-saccades in nonhuman primates. J. Cogn. Neurosci. 23: 481-490


Womelsdorf T, Johnston K, Vinck M, Everling S (2010) Theta-band synchronization
in anterior cingulate cortex predicts task-rules and their adjustments following errors. Proceedings of the National Academy of Sciences (USA) 107: 5248-5253




Innovation and Excellence in Research and Teaching