Lina Dagnino, Ph.D.

Professor

Lina Dagnino

PH.D. University of Alberta
B. Chemistry Universidad Autonoma del Estado de Mexico
Western University
Professor, Department of Physiology and Pharmacology
Children's Health Research Institute
Scientist, Developmental Biology Program
Lawson Health Research Institute
Scientist, Children's Health Research Institute


Office: Medical Science Bldg. rm. 288
Tel: (519) 661-4264
Fax: (519)-661-3827
E-mail: ldagnino@uwo.ca
See publications by Lina Dagnino on PubMed
www.chri.org/directory/lina-dagnino


DagninoDr. Dagnino’s research focus is on skin biology and stem cells.  Her expertise includes cellular and molecular biology, as well as developmental genetics.

DagninoThe skin is the largest organ in the body. It weighs 6-9 pounds and, if one could take it off and lay it flat, it would cover an area of about 20 ft2 (2 m2). The skin fulfills myriad functions. It serves as a barrier between the body and the outside environment, protecting it from chemicals, physical damage, and entry of infectious organisms. It also prevents dehydration and heat loss, and allows perception of touch, a quintessential source of sensory stimulation. 

Dagnino

Three layers form the skin. The uppermost layer is the epidermis, which is formed by epithelial cells called keratinocytes.These cells also form hair, nails, teeth and sebaceous glands. Keratinocyte stem cells constantly differentiate and migrate from the base of the epidermis towards the outer surface of the skin, where they are sloughed off.

Dagnino

This process normally takes about a month, but in people suffering from skin disorders, such as psoriasis, it can be accelerated, sometimes occurring in a few days. Over 30,000 cells are shed from the skin every minute, and the skin can be maintained only because it has a large reservoir of keratinocyte stem cells.

Dr. Dagnino’s laboratory works on the mechanisms that are involved in cellular decisions to maintain an undifferentiated, stem-cell phenotype or follow a pathway of terminal differentiation in the keratinocytes of the epidermis. Her group is currently investigating how those mechanisms regulate normal regeneration after wounding, abnormal proliferation and cancer, as well as how they contribute to block microbial invasion.

 

Selected Publications


1.
 L Vi, C de Lasa, G DiGuglielmo and L Dagnino. Integrin-linked kinase is essential for transforming growth factor-beta induced myofibroblast differentiation. J Invest Dermatol 131:586-593, 2011
2.  L Dagnino. Integrin-linked kinase: A scaffold protein unique among its ilk. J Cell Commun Signal, 5:81-83, 2011
3. KA Nakrieko, A Rudkouskaya, TS Irvine, SJA D’Souza and L Dagnino. Targeted inactivation of integrin-linked kinase  in hair follicle stem cells reveals an important modulatory role in skin repair after injury. Mol Biol Cell, 14:2532-2540, 2011
4. E Ho and L Dagnino. Epidermal growth factor induction of front-rear polarity and migration in keratinocytes is mediated by integrin-linked kinase and ELMO2. Mol Biol Cell 23: 492-502, 2012
5. D Judah, A Rudkouskaya, R Wilson, D. E. Carter and L Dagnino. Multiple roles of integrin-linked kinase in epidermal development, maturation and pigmentation revealed by molecular profiling. PLOS One, 7(5):e36704, 2012
6. E Ho and L Dagnino. Emerging role of ILK and ELMO2 in the integration of adhesion and migration pathways. Cell Adhesion and Migration 6 (3): 168-172, 2012
7. S Sayedyahossein, L Nini, TS Irvine, and L Dagnino. Essential role of integrin-linked kinase in regulation of phagocytosis in keratinocytes. FASEB J, 26:4218-4229, 2012
8. S Sayedyahossein, and L Dagnino.  Integrins and small GTPases as modulators of phagocytosis. Int Rev Cell Mol Biol 302: 319-352, 2013.
9. S Boo and L Dagnino. Integrins as modulators of TGF-signaling in skin regeneration after injury. Adv Wound Care 2:225-237, 2013.




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