Our lab is interested in studying the dysregulation of G protein-coupled receptor (GPCR) signalling in diseases such as cancer.
Our current research focuses on understanding the molecular mechanisms by which certain GPCRs expressed in breast cancer cells can regulate the processes of cell migration and invasion, processes that lead to metastasis. We use various molecular, cellular and advanced microscopy imaging techniques to study gene expression and protein-protein interactions in normal (non-malignant) cells and cancer cells. We are also keenly interested in studying the function of these proteins in vivo and current efforts are focused on establishing animal model studies with excellent collaborators, to determine tumorigenicity and metastasis, using breast carcinoma where the expression of these proteins have been silenced.
Nov 2012: Congratulations to Jeff Law for winning the Bill Bottom Award for an exceptional Physiology MSc thesis!
Oct 2012: Congratulations to Donna Cvetkovic for successfully completing her MSc. degree.