Beier Lab

Publications

Beier Lab PubMed Publication List

  • Caskenette, D., Penuela, S., Lee, V., Barr, K., Beier, F., Laird, D.W., Willmore, K.E. (2016). Global deletion of Panx3 produces multiple phenotypic effects in mouse humeri and femora. J Anat 228: 746–56. [View HTML]
  • Poulet, B., Beier, F. (2016). Targeting oxidative stress to reduce osteoarthritis. Arthritis Res Ther 2016;18: 32. [View HTML]
  • Ratneswaran, A., and Beier, F. (2015). A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis. Science Signaling 8, fs14. Invited ‘Focus’ Article. [View HTML]
  • Attur, M., Yang, Q., Shimada, K., Tachida, Y., Nagase, H., Mignatti, P., Statman, L., Palmer, G., Kirsch, T., Beier, F., et al. (2015). Elevated expression of periostin in human osteoarthritic cartilage and its potential role in matrix degradation via matrix metalloproteinase-13. FASEB J. 29, 4107–4121. [View HTML]
  • Moon, P.M., and Beier, F. (2015). Novel insights into osteoarthritis joint pathology from studies in mice. Current Rheumatology Reports 17, 524. [View HTML]
  • Hamilton, C. B., Pest, M. A., Pitelka, V., Ratneswaran, A., Beier, F.,# and Chesworth, B. M.# (2015). Weight-bearing asymmetry and vertical activity differences in a rat model of post-traumatic knee osteoarthritisOsteoarthritis & Cartilage 23, 1178-1185. #co-corresponding authors. [View HTML]
  • Kim, G.-W., Han, S.-W., Park, H.-R., Lee, E.-J., Jung, Y.-K., Usmani, S.E., Ulici, V., Han, M.-S.#, and Beier, F.# (2015). CXC chemokine ligand 12a enhances chondrocyte proliferation and maturation during endochondral bone formation. Osteoarthritis & Cartilage 23, 966-974. #co-corresponding authors. [View HTML]
  • Holm, E., Aubin, J.E., Hunter, G.K., Beier, F., and Goldberg, H.A. (2015). Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone 71, 145-154. [View HTML]
  • Ratneswaran, A., LeBlanc, E.A., Walser, E., Mort, J.S., Welch, I., Borradaile, N., and Beier, F. (2015). Peroxisome Proliferator-Activated Receptor delta promotes the progression of post-traumatic osteoarthritis in a mouse model. Arthritis & Rheumatology 67, 454-464. Featured on CTV News (TV), Rogers TV, Rheumatology Morning Wire (American College of Rheumatology). [View HTML]

  • Zhang, X., Zhu, J., Liu, F., Li, Y., Chandra, A., Beier, F., Enomoto-Iwamoto, M., and Qin, L. (2014). Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Research 2, 14015. [View HTML]

  • Pest MA, Russell BA, Zhang YW, Jeong JW, Beier F. (2014). Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction. Arthritis Rheumatol. 66(10), 2816-27. [View HTML]
  • Sun, M.M., and Beier, F. (2014). LXR activation delays chondrocyte hypertrophy during endochondral bone growth. Osteoarthritis & Cartilage. 22, 996–1006 [View HTML]
  • Forristal, C., Henley, S., MacDonald, J., Bush, J.R., Ort, C., Passos, D.T., Talluri, S., Ishak, C.A., Thwaites, M., Norley, C.J., Litovchick, L., DeCaprio, J.A., DiMattia, G., Holdsworth, D., Beier, F., and. Dick, F.A. (2014). Loss of the mammalian DREAM complex deregulates chondrocyte proliferation. Mol. Cell. Biol.34, 2221–34. [View HTML]
  • Sun, M.M., and Beier, F. (2014). Chondrocyte hypertrophy in skeletal development, growth and disease. Birth Defects Research C: Embryo Today 102, 74-82. [View HTML]
  • Watson, L.A., Solomon, L.A., Li, J., Jiang, Y., Edwards, M., Shin-ya, K., Beier, F., and Bérubé, N.G. (2013). ATRX deficiency induces telomere dysfunction, endocrine defects, and reduced lifespan. J. Clin. Invest. 123, 2049-2063. Featured by Faculty of 1000. [View HTML]
  • Solomon, L.A., Russell, B., Watson, L.A., Beier, F.#, and Bérubé, N.G.(2013). Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly. Hum. Mol. Genetics 22, 5015-5025(# indicates co-corresponding authors). [view HTML]
  • Jung, Y.-K., Kim, G.-W., Park, H.-R., Lee, E.-J., Choi, J.-Y.BeierF.and Han, S.-W. (2013). Role of Interleukin-10 in endochondral bone formation: Anabolic effect via BMP/Smad pathway. Arthritis & Rheumatism 65, 3153-3164. [view HTML]
  • Bush, J.R., and Beier, F. (2013). TGF-beta and osteoarthritis – the good and the bad. Nature Medicine 19, 667-669. [view HTML]

  • Vasheghani, F., Monemdjou, R., Fahmi, H., Zhang, Y., Perez, G., Blati, M., St-Arnaud, R., Pelletier, J.-P, Beier, F., Martel-Pelletier, J., and Kapoor, M. (2013). Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. Am. J. Pathology 182, 1099-1106.[view HTML]

  • Usmani, S.E., Pest, M., Kim, G.W., Ohora, S., Qin, L., and Beier, F. (2012).  Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth. Bone 51, 131-141. [view HTML]

  • Yan, Q., Feng, Q., and Beier, F. (2012). Reduced chondrocyte proliferation, increased apoptosis and premature differentiation in neuronal nitric oxide synthase-deficient mice. Osteoarthritis & Cartilage 20, 144-151. [view HTML]

  • Usmani, S.E*, Appleton, C.T.G., and Beier, F. (2012). Transforming growth factor alpha induces endothelin receptor A expression in osteoarthritis. J. Orthop. Res., 30 1391-1397 (Epub March 7, 2012).

  • Wang G, Yan Q, Woods A, Aubrey LA, Feng Q, Beier F. (2011) Inducible nitric oxide synthase-nitric oxide signaling mediates the mitogenic activity of Rac1 during endochondral bone growth. J Cell Sci. 2011 Oct 15;124(Pt 20):3405-13. Epub 2011 Sep 29. 

  • Gillespie, J.R., Ulici, V., Dupuis, H., Higgs, A., DiMattia, A., Patel, S., Woodgett, J.R., and Beier, F. (2011). Deletion of Glycogen Synthase Kinase-3β in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3a Protein Expression. Endocrinology 152, 1755-1766

  • Zhang, X., Siclari, V.A., Lan, S., Zhu, J., Koyama, E., Dupuis, H.L., Enomoto-Iwamoto, M., Beier, F., and Qin, L. The critical role of the epidermal growth factor receptor (EGFR) in endochondral ossification. J. Bone Miner. Res., Epub Sept. 1, 2011.

  • Appleton, C.T.G., Usmani, S.E., Mort, J., and Beier, F. (2010). RhoA/ROCK and MEK/ERK mediation of transforming growth factor alpha signaling in articular cartilage degeneration. Lab. Invest. 90, 20 -30.[View HTML]

  • Ulici, V., James, C.G., Hoenselaar, K., and Beier, F. (2010). Genome-wide analyses of PI3 kinase target genes in chondrocytes. PLoS ONE 5, e8866.

  • Ulici, V., Hoenselaar, K.D., Agoston, H., McErlain, D.D., Umoh, J., Chakrabarti, S., Holdsworth, D.W., and Beier, F. (2009). The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone45, 1133-1145.

  • Attur, M.G., Palmer, G.D., Al-Mussawir, H.E., Dave, M., Teixeira, C.C., Rifkin, D.B., Appleton, C.T.., Beier, F., and Abramson, S. B. (2009). F-spondin, a neuroregulatory protein, is upregulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. FASEB J. 23, 79-89.[View HTML]

  • Welch, I., Cowan, M., Beier, F., and Underhill, T.M. (2009). The retinoic acid binding protein Crabp2 is increased in murine models of degenerative joint disease. Arthritis Res. Ther. 11: R14. [PubMed

  • Cecil, D.L., Appleton, C.T.G., Polewski, M.D., Mort, J.S., Bendele, A., Beier, F., and Terkeltaub, R. (2009). The pattern recognition receptor CD36 is a chondrocyte hypertrophy marker associated with suppression of catabolic responses and promotion of repair responses to inflammatory stimuli. J. Immunology 182, 5024-5031.[View HTML]

  • Appleton, C.T.G., Usmani, S.E., Mort, J., and Beier, F. (2009). Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation. Lab. Invest., Epub Oct. 12, 2009. [View HTML]

  • Ulici, V., Hoenselaar, K.D., Gillespie, J.R., and Beier, F. (2008). The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation. BMC Dev. Biol. 8:40. [View HTML]

  • Stanton, L.A., Li, J., and Beier, F. (2008). PPARγ2 expression in growth plate chondrocytes is regulated by p38 and GSK-3. J Cell Mol Medicine, Epub June 20, 2008.[PubMed]

  • Gill, K.S., Beier, F., and Goldberg, H. (2008). Rho-Rock Signaling Differentially Regulates Chondrocyte Spreading on Fibronectin and Bone Sialoprotein. Am J Physiology: Cell Physiology 295, C38-49.[PubMed]

  • McErlain DD, Appleton CT, Litchfield RB, Pitelka V, Henry JL, Bernier SM, Beier F, Holdsworth DW. (2008) Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography.Osteoarthritis Cartilage 16(4): 458-469.[PubMed]

  • Woods, A., Khan, S., and Beier, F. (2007) C-Type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis. Endocrinology [PubMed]

  • Agoston, H., Khan, S., James, C.G., Gillespie, J.R., Serra, R., Stanton, L.-A., and Beier, F. (2007) C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and -independent pathways.BMC Developmental Biology 7:18. [View HTML]

  • Appleton, C.T.G., Pitelka, V., Henry, J.L., and Beier, F. (2007) Genome-wide analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 56(6):1854-1868.[PubMed]

                                              • Marinovich, R., Soenjaya, Y., Wallace, G.Q., Zuskov, A., Dunkman, A., Foster, B.L., Ao, M., Bartman, K., Lam, V., Rizkalla, A., Beier, F., Somerman, M.J., Holdsworth, D.W., Soslowsky, L.J., Lagugné-Labarthet, F., Goldberg, H.A. (2016). The role of bone sialoprotein in the tendon-bone insertion. Matrix Biol 52–54: 325–38.  [View HTML]

                                              • Moon, P.M.&, Penuela, S.&, Barr, K., Khan, S., Pin, C.L., Welch, I., Laird, D.W.#, and Beier, F.# (2015). Deletion of Panx3 prevents the development of surgically induced osteoarthritis. J Mol Med (Berl). 2015;93: 845–565.  &co-first authors; #co-corresponding authors. [View HTML]
                                              • Appleton, C.T.G.#, Usmani, S.E., Pest, M., Pitelka, V., Mort, J.S., and Beier, F.(2015). The TGFa-CCL2 axis is a target for treatment of osteoarthritis. Arthritis Rheumatol (Hoboken, NJ). 2015;67: 2691–701.#co-corresponding authors. [View HTML]

                                              • McCann, M.R., Patel, P., Pest, M.A., Ratneswaran, A., Lalli, G., Beaucage, K.L., Blackler, G.,  Kamphuis, M., Esmail, Z., Lee, J., Barbalinardo, M., Mort, J., Holdsworth, D.W., Beier, F., Dixon, S.J., Seguin, C.A. (2015).  Repeated exposure to high-frequency low-amplitude vibration induces degeneration of intervertebral disc and knee joints in a murine model. Arthritis Rheumatol (Hoboken, NJ). 2015;67: 2164–75. [View HTML]

                                              • Bush, J.R., Bérubé, N.G., and Beier, F. (2015). A new prescription for growth? Statins, cholesterol and cartilage homeostasis. Osteoarthritis & Cartilage 23, 503-506. [View HTML]

                                              • Holm, E., Gleberzon, J.S., Liao, Y., Sørensen, E.S, Beier, F., Hunter, G.K., and Goldberg, H.A. (2014). Osteopontin mediates mineralization and not osteogenic cell development in vitro. Biochem. J. 464, 355-364. [View HTML]
                                              • Moyer, R., Ratneswaran, A., Beier, F., and Birmingham, T. (2014). Osteoarthritis Year in Review 2014: Mechanics – basic and clinical studies in osteoarthritis. Osteoarthritis & Cartilage 22, 1989-2002. [View HTML]

                                              • Pest MA, Beier F. (2014). Developmental biology: Is there such a thing as a cartilage-specific knockout mouse? Nat Rev Rheumatol. Nature Reviews Rheumatology, 10:702–704 [View HTML]

                                              • Beier F. (2014). Changes in mRNA stability in chondrocytes: There's more to osteoarthritis than transcription. Arthritis Rheumatol. Arthritis & Rheumatology, 66: 2921–2923. [View HTML]

                                              • Palmer GD, Attur MG, Yang Q, Liu J, Moon P, Beier F, and Abramson, S. (2014). F-spondin deficient mice have a high bone mass phenotype. PLoS One, 9:e98388. [View HTML]
                                              • Beier, F. (2014). NFATs are good for your cartilage! Osteoarthritis & Cartilage, 22, 893–5. [View HTML]
                                              • Li, Z., Wu, G., Sher, R.B., Khavandgar, Z., Hermansson, M., Cox, G.A., Doschak, M.R., Murshed, M., Beier, F. and Vance, D.E. (2014). Choline kinase beta is required for normal endochondral bone formation. Biochim. Biophys. Acta 1840, 2112-2122. [View HTML]
                                              • Fang. H., and Beier, F. (2014). Mouse models of osteoarthritis: modelling risk factors and assessing outcomes. Nature Reviews Rheumatology. 10:413–21. [View HTML]
                                              • Staal, B., Williams, B.O., Beier, F., Vande Woude, G.F., and Zhang, Y.-W. (2014). Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. Proc. Natl. Acad. Sci. USA111, 2590-2595. [View HTML]
                                              • Solomon, L.A., Russell, B., Makar, D., Bérubé, N.G.#, and Beier, F.# (2013).Loss of ATRX does not confer susceptibility to osteoarthritis. PLoS ONE8:e85526(# indicates co-corresponding authors). [View HTML]
                                              • Gillespie, J.R., Bush, J.R., Bell, G.I., Aubrey, L.A., Dupuis, H., Ferron, M., Kream, B., DiMattia, G., Patel, S., Woodgett, J.R., Karsenty, G., Hess, D., and Beier, F. (2013).GSK-3β function in bone regulates skeletal development, whole body metabolism and male life span. Endocrinology 154, 3703-3718.  Featured as ‘Research Highlight’ by Nature Reviews Endocrinology Aug. 2013 [view HTML]
                                              • Lai, Y., Bai, X., Zhao, Y., Tian, Q., Liu, B., Lin, E.A., Chen, Y., Lee, B., Appleton,C. T. G., Beier, F., Yu, X.-P., and Liu, C.J. (2014). ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis. Ann. Rheum. Dis. 73, 1575-1584. Featured as ‘Research Highlight’ by Nature Reviews Rheumatology Oct. 2013 [view HTML]

                                              • Poulet, B., Ulici, V., Stone, T.,C. Pead, M., Gburcik, V., Constantinou, E., Palmer, D.B., Beier, F., Timmons, J.A., and Pitsillides, A.A. (2012).  Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis. Arthritis & Rheumatism 64, 3256-3266. [view HTML]

                                              • Fosang, A.J., and Beier, F. (2011). Emerging Frontiers in Cartilage and Chondrocyte Biology. Best Practice and Research Clinical Rheumatology 25, 751-766. [view HTML]

                                              • McErlain, D.D., Ulici, V., Darling, M., Gati, J.S., Pitelka, V., Beier, F., and Holdsworth, D.W. (2012). Initiation and progression of subchondral cysts in an in vivo, preclinical model of osteoarthritis.Arthr. Res. Therapy 14: R26. [view html]

                                              • Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. (2011) Cartilage-specific deletion of PPARγ results in abnormal endochondral ossification, and cartilage growth and development. Arthritis Rheum. 2011 Nov 30. 1551-1561. [Epub ahead of print] 

                                              • Pitsillides AA, Beier F. (2011) Cartilage biology in osteoarthritis--lessons from developmental biology. Nat Rev Rheumatol. 2011 Sep 27;7(11):654-63. doi: 10.1038/nrrheum.2011.129.

                                              • LeBlanc, E.A., and Beier, F. (2011). New insights in the pathobiology of cartilage degeneration: Implications for therapeutic interventions in osteoarthritis. US Musculoskeletal Review 6, 16-19. 

                                              • Stanton, L-A., Li, J.R., and Beier, F. (2010).  PPAR gamma2 expression in growth plate chondrocytes is regulated by p38 and GSK-3. J. Cell. Mol. Medicine 14, 242-256.[PubMed]

                                              • James, C.G., Stanton, L.-A., Agoston, H., Ulici, V., Underhill, T.M., and Beier, F. (2010). Genome-wide analyses of gene expression during mouse endochondral ossification. PLoS ONE 5, e8693.

                                              • Yan, Q., Feng, Q., and Beier, F. (2010). Endothelial nitric oxide synthase deficiency results in reduced chondrocyte proliferation and endochondral bone growth. Arthr. & Rheum. 62, 2013-2022.

                                              • Woods, A., Pala, D., Kennedy, L., McLean, S., Wang, G., Leask, A., and Beier, F. (2009). Rac1 Signaling Regulates CCN2/CTGF Gene Expression via TGFß/Smad Signaling in Chondrocytes. Osteoarthritis & Cartilage 17, 406-413.[PubMed]

                                              • Wang, J., Beier, F., Tsui, H.W., and Tsui, F.W.L. (2009). The C PPDD-associated ANKH M48T mutation interrupts the interaction of ANKH with the sodium/phosphate cotransporter PiT-1. J. Rheumatology 36, 1265-1272. [View HTML]

                                              • Woods, A., Wang, G., James, C.G., Dupuis, H., and Beier, F. (2009). Microarray analyses of chondrocyte gene expression in response to manipulation of the actin cytoskeleton: Identification of a central role of RORa signaling. J. Cell. Mol. Med., Epub Jan 28, 2009. [PubMed]

                                              • Ulici, V., Hoenselaar, K.D., Agoston, H., McErlain, D.D., Umoh, J., Chakrabarti, S., Holdsworth, D.W., and Beier, F. (2009). The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone, Epub Aug. 10, 2009. [PubMed]

                                              • Solomon, L., Li, J., Bérubé, N.G., and Beier, F. (2009). Loss of ATRX function in cartilage results in only minor skeletal defects. PLoS ONE 4, e7106.[View HTML]

                                              • Solomon, L.A., Bérubé, N.G., and Beier, F. (2008). Transcriptional regulators of chondrocyte hypertrophy. Birth Defects Research – Embryo Today 82, 123-130. [PubMed]

                                              • Teixeira, C., Agoston, H., and Beier, F. (2008). Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification. Dev Biol, 319, 171-178. [PubMed]

                                              • Pala, D., Woods, A., Kennedy, L., Liu, S., Chen, S.,Bursell, L., Lyons, K.M., Carter, D.E., Beier, F., and Leask, A. (2008) Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem283(14):9239-9247. [PubMed]

                                              • Bursell, L., Woods, A., James, C.G., Pala, D., Leask, A., and Beier, F. (2007) Src kinase inhibition promotes the chondrocyte phenotype. Arthritis Res Ther 9(5):R105. [PubMed]

                                              • Wang, G., Woods, A., Agoston, H., Ulici, V., Glogauer, M., and Beier, F. (2007) Genetic Ablation of Rac1 in Cartilage Results in Chondrodysplasia. Dev Biol 306:612-623. [View HTML]

                                              • Woods, A., Wang, G. and Beier, F. (2007) Regulation of Chondrocyte Differentiation by the Actin Cytoskeleton and Adhesive Interactions. J Cell Physiol. 2007 Oct;213(1):1-8.[PubMed]

                                              • Appleton, C.T.G., McErlain, D.D, Pitelka, V., Schwartz, N., Bernier, S.M., Henry, J.L., Holdsworth, D.W., and Beier, F. (2007) Forced mobilization accelerates pathogenesis: Characterization of a pre-clinical surgical model of osteoarthritis. Arthitis Res Ther 9(1):R13. [PubMed]