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Clinical Activities

Keywords: Pathology, diseases of the breast, breast cancer

Description of Clinical Activities: Pathologist, Consultant in Breast Pathology

Research Interests

Keywords: Breast cancer, metastasis, progression, cell and molecular biology, translational research

Description of Research Activities:

• Molecular and Cellular Biology of Breast Cancer
• Mechanisms of Breast Cancer Progression
• Mechanisms of Metastasis
• Translational Breast Cancer Research
• Role of the secreted protein osteopontin in malignancy

Selected Publications

1. Pandit, T.S., Kennette, W., MacKenzie, L., Zhang, G., Al-Katib, W., Andrews, J., Vantyghem, S.A., Ormond, D.G., Allan, A.L., Rodenhiser, D.I., Chambers, A.F., and Tuck, A.B. (2009). Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment. International Journal of Oncology, 35: 297-308.
2. Andrews, J., Kennette, W., Pilon, J.M., Hodgson, A., Tuck, A.B., Chambers, A.F., and Rodenhiser, D.I. (2010). Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number. PloS One, 5(1): e8665. doi:10.1371/journal.pone.0008665.
3. Souter, L.H., Andrews, J.D., Zhang, G., Cook, A.C., Postenka, C.O., Al-Katib, W., Leong, H.S., Rodenhiser, D.I., Chambers, A.F., and Tuck, A.B. (2010). Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns. Laboratory Investigation, e-pub ahead of print.
4. Cook, A.C., Tuck A.B., Turner, J., Irby, R., Yeatman, T.J., and Chambers, A.F. (2005). Osteopontin induces multiple changes in gene expression that reflect the six “hallmarks of cancer” in a model of breast cancer progression. Molecular Carcinogenesis, 43: 225-236.
5. Tuck, A.B., Allan, A.L., and Chambers, A.F. (2007). Osteopontin overexpression in breast cancer: Knowledge gained and possible implications for clinical management. Journal of Cellular Biochemistry, 102: 859-868.
6. Allan, A.L., Vantyghem, S.A., Tuck, A.B., and Chambers, A.F. (2007). Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis. Breast Disease, 26: 87-98.
7. Rodenhiser, D.I., Andrews, J., Kennette, W., Sadikovic, B., Mendlowitz, A., Tuck, A.B., and Chambers, A.F.  (2008) Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.  Breast Cancer Research, 10: R62.

8. Bramwell, V.H., Doig, G.S., Tuck, A.B., Wilson, S.M., Tonkin, K.S., Tomiak, A., Perera, F., Vandenberg, T.A., and Chambers, A.F. (2009). Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer.  Breast Cancer Res. Treat., 114: 503-511.