Patrick P.W. Luke

Professor, Department of Surgery
The University of Western Ontario
Co-Director of the Multiorgan Transplant Program

London Health Sciences Centre

Director of Experimental Microsurgery
Matthew Mailing Centre

Surgical Director, Kidney/Pancreas Transplantation
London Health Sciences Centre

MD University of Toronto

Office:London Health Sciences Centre – University Hospital
339 Windermere Road, London, Ontario, Canada N6A 5A5
Phone: (519) 663-3180
Fax: (519) 663-3858

Clinical Activities

Keywords: kidney/pancreas transplantation, robotics, telesurgery, telementoring, laparoscopy, minimally invasive surgery, renal cell carcinoma

Research Interests

transplantation immunology, immunotherapy, organ preservation, optimization of organ function post-transplant, dendritic cells, ischemia reperfusion injury, carbon monoxide releasing molecules, allograft transplantation 

Description of Research Activities

Research in this laboratory is directed towards basic and translational studies in immunology as it pertains to transplantation, acute/chronic graft rejection and organ failure.

Allogeneic discrepancies between donor and host lead to graft infiltrating T cells, mast cells and macrophage, with accompanied chemokine, cytokine and growth factor responses. We found that carbon monoxide releasing molecules (CORMs) protect renal allograft function and survival through modification of multiple pathways associated with immune-modulatory cells. Research projects in this laboratory aim i) to understand the role of specific innate immune receptors (Toll-like receptors or TLRs) involved in the process of initiating adaptive immune mediated renal graft rejection  ii) to develop immune therapy through dendritic cell-mediated immune modulation by using inhibitor of innate immune signaling proteins in rat and mouse models in vivo.  iii) to assess the ability of several CORMs to affect the post-transplant protection of the renal graft from chronic injury iv) to delineate immune modulatory mechanism of function of CORMs as well as TLRs non-toxic inhibitors and antagonist in an in vivo transplant model. v) To identify pharmacological bioactive agents (i.e., gases ) for better organ preservation to prevent organ damage due to ischaemia  or infiltration of mononuclear cells upon re-perfusion. 

Selected Publications

  1. Sun T, Arp J, Salna M, Lan Z, Min W, Sener A, Jevnikar AM, Luke PP. Influence of CORM-3 treatment on dendritic cell maturation and infiltration. Am J Transplantation  s5(13):375, 2013.

  2. Sener A, Tran KC, Deng JP, Garcia B, Lan Z, Liu W, Sun T, Arp J, Salna M, Acott P, Cepinskas G, Jevnikar AM, Luke PP. Carbon Monoxide Releasing Molecules Inhibit Cell Death Resulting from Renal Transplantation Related Stress. J Urol. (12) 05847-8. 2012.

  3. Caumartin Y, Stephen J, Deng JP, Lian D, Lan Z, Liu W, Garcia B, Jevnikar AM, Wang H, Cepinskas G, Luke PP. Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation. Kidney Int. 79(10):1080-9.2011.

  4. Nguan CY, Sener A, Karnik V, Caumartin Y, House AA, McAlister VC, Luke PP. Perfusion of renal allografts with verapamil improves graft function. Transplantation. 86(10):1463-7. 2008.

  5. Luke PP, Nguan CY, Horovitz D, Gregor L, Warren J, House AA. Immunosuppression without calcineurin inhibition: optimization of renal function in expanded criteria donor renal transplantation. Clin Transplant. 23(1):9-15. 2008.

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