Finding Your Way

Dr. B. Garcia

Bertha Garcia

Vice Dean, Education in the
Schulich School of Medicine & Dentistry

MD Peru
FRCPC
M.Ed OISE, Toronto

Office: Dental Sciences Building, Room 4044
Phone: (519) 661-2030
Fax: (519) 661-3370
E-mail: bertha.garcia@lhsc.on.ca
Visit: The Experimental Transplantation Pathology Lab Website

 

Clinical Activities

Chief of Department of Pathology, LHSC/SJHC and Medical Leader, London Laboratories Services Group Program Transplant Pathology, Gastrointestinal Pathology, Lung Pathology, Cytopathology

Research Interests

Keywords: Transplantation, animal models

Description of Research Activities: The experimental transplantation pathology laboratory is a core facility for the support of the Multi-Organ Transplantation Program at the London Health Sciences Centre.

Selected Publications

  1. Ge W, Jiang J, Baroja ML, Arp J, Zassoko R, Liu W, Bartholomew A, Garcia B, and Wang H. Infusion of Mesenchymal Stem Cells and Rapamycin Synergize to Attenuate Alloimmune Responses and Promote Cardiac Allograft Tolerance. American Journal of Transplantation 2009 (In press).
  2. Wang H, Ge W, Arp J, Zassoko R, Liu W, Ichim TE, Jiang J, Jevnikar AM and Garcia B. Free Bone Graft Attenuates Acute Rejection and in Combination with Cyclosporine Leads to Indefinite Cardiac Allograft Survival. Journal of Immunology 2009; 182: 5970-5981.
  3. Rother RP, Arp J, Jiang J, Ge W, Faas SJ, Liu W, Gies DR, Jevnikar AM, Garcia B, and Wang H. C5 Blockade with Conventional Immunosuppression Induces Long-Term Graft Survival in Presensitized Recipients. American Journal of Transplantation 2008; 8: 1129 - 1142.
  4. Haeryfar SMM, Lan Z, Leon-Ponte M, Duffy KRL, Ge W, Liu W, Mele T, Garcia B and Wang H. Prolongation of cardiac allograft survival by rapamycin and the invariant natural killer T (iNKT) cell glycolipid agonist OCH. Transplantation 2008; 86: 460-468.
  5. Liu W, Zassoko R, Mele T, Luke P, Sun H, Liu W, Garcia B, Jiang J and Wang H. Establishment of duodeno-jejunal bypass surgery in mice: a model designed for diabetic research. Microsurgery 2008; 28(3): 197-202.
  6. Ma Y, He KM., Garcia B, Min W, Jevnikar A, Zhang ZX. Adoptive transfer of double negative T regulatory cells induces B-cell death in vivo and alters rejection pattern of rat-to-mouse heart transplantation. Xenotransplantation 15(1):56-63, 2008. 154.
  7. Fairhead T, Lian D, McCully ML, Garcia B, Zhong R, Madrenas J. RIP2 is required for NOD signaling but not for Th1 cell differentiation and cellular allograft rejection. Am J Transplant 8(6):1143-1150, 2008. 156.
  8. Li M, Zhang X, Zheng X, Lian D, Zhang Z-X, Sun H, Vladau C, Suzuki M, Huang X, Xia X, Zhong R, Garcia B, Min WP. Immune modulation and tolerance transfer by tolerogenic dendritic cells. Int. Immunol. 20(2):285-293, 2008.
  9. Jiang J, Arp J, Kubelik D, Zassoko R, Liu W, Wise Y, Macaulay C, Garcia B, McFadden G, Lucas A and Wang H. Induction of Indefinite Cardiac Allograft Survival Correlates with Toll-like Receptor 2 and 4 Downregulation after Serine Protease Inhibitor-1 (Serp-1) Treatment. Transplantation 2007; 84(9): 1158-1167.
  10. Wang H, Arp J, Liu W, Faas S, Jiang J, Gies D, Garcia B, Zhong R and Rother R. Inhibition of Terminal Complement Components in Presensitized Transplant Recipients Prevents Antibody-Mediated Rejection Leading to Long-Term Graft Survival and Accommodation. Journal of Immunology 2007; 179: 4451-4463.
  11. Chen G, Luke PW, Yang H, Visser L, Sun H, Garcia B, Qian H, Xiang Y, Huang X, Liu W, Senaldi G, Schneider A, Poppema S, Wang H, Jevnikar AM, Zhong R. Anti-CD45RB Monoclonal Antibody Prolongs Renal Allograft Survival in Cynomolgus Monkeys. American Journal of Transplantation 2007; 7: 27-37.
  12. Zhang Z, Ma Y, Wang H, Arp J, Jiang J, Huang X, He KM, Garcia B, Madrenas J and Zhong R. Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway. Journal of Immunology 2006; 177(10): 6920-6929.
  13. Wang H, Arp J, Huang X, Liu W, Ramcharran S, Jiang J, Garcia B, Kanai N, Min W, O’Connell PJ, and Zhong R. Distinct subsets of dendritic cells regulate the pattern of acute xenograft rejection and susceptibility to cyclosporine therapy. Journal of Immunology 2006; 176(6): 3525-35.
  14. Wang H, Hosiawa K, Min W, Yang J, Zhang X, Garcia B, Ichim TE, Zhou D, Lian D, Kelvin D and Zhong R. Cytokines regulate the pattern of rejection and susceptibility to cyclosporine therapy in different mouse recipient strains after cardiac allografting. Journal of Immunology 2003; 171(7): 3823-3836.
  15. Wang H, DeVries ME, Deng S, Khandaker MH, Pickering JG, Chow LH, Garcia B, Kelvin DJ and Zhong R. The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection. Nature Medicine 2000; 6: 549-55.

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