title:
<h2 align=center>Cell Injury</h2>
<p>Practice your knowledge of the concepts raised in the small group discussions dealing with <b>cell injury</b>.  
<br>In the multiple choice answers click on whichever answer you feel is the <b>most</b> appropriate.  In some questions there may be more than one appropriate answer.  Type in your answers to the short questions in the text box which appears on the screen.  When finished submit your quiz for marking and your result will be returned to you within a few seconds.  Only the answers to the multiple choice questions are used in calculating your score.<br>
THESE TESTS ARE ONLY TO HELP YOU LEARN THE MATERIAL AND THE "GRADE" IS NOT RECORDED.

<p><hr size=4>
header:
<h2 align=center>Cell Injury</h2>
footer:

<p><address>Please e-mail feedback to <a href="mailto:bertha.garcia@lhsc.on.ca">The Meds I Pathology Course Coordinator</a></address>

delivery:
simultaneous

question:
Each of the following are features of <b>reversible</b> cell injury EXCEPT:
ans:
swollen cytoplasm
fbk:
No -   cell swelling due to the influx of sodium can be reversed.
ans:
granular cytoplasm
fbk:
No - this process is reversible
ans:
karyolysis
fbk:
Yes - the dissolution of DNA and disappearance of the nucleus indicates the death of the whole cell - this process is irreversible.
ans:
eosinophilic deposits between cells
fbk:
No - this process is reversible.
correct_answer:
3

<p>
question:
Lethally injured cells have decreased:
ans:
ATP - adenosine triphosphate
fbk:
Yes - partially correct.  pH is also decreased (i.e. the cell becomes acidic) and  RNA synthesis is also decreased.
ans:
pH
fbk:
Yes - partially correct.  There is an accumulation of lactic acid and intracellular acidosis.  ATP and RNA synthesis are also decreased.
ans:
RNA synthesis
fbk:
Yes - partially correct.  ATP production and RNA synthesis are also decreased.
ans:
sodium
fbk:
No - sodium is increased.
mult_ans:
1 2 3
<p>

question:
Light microscopic features of lethally injured cells include:
ans:
karyorrhexis
fbk:
Yes  - partially.  The fragmentation of the nucleus is one feature of irreversible cell injury.
ans:
pyknosis
fbk:
Yes - partially. The condensation of chromatin and shrinking of the nucleus is one feature of irreversible cell injury.
ans:
karyolysis
fbk:
Yes - partially.  The lysis of nuclear contents indicates irreversible cell injury leading to cell death.
ans:
increased basophilia of the cytoplasm
fbk:
No - the cytoplasm becomes eosinophilic as a result of changes in proteins and RNA.
mult_ans:
1 2 3
<p>

question:
The death of cells within a living body is termed:
ans:
cytolysis
fbk:
No
ans:
necrosis
fbk:
Yes - by definition.
ans:
putrefaction
fbk:
No
ans:
autolysis
fbk:
No
ans:
somatic death
fbk:
No
correct_answer:
2
<p>

question:
Which one of the following features is most characteristic of necrosis?
ans:
dilation of blood vessel
fbk:
No
ans:
disappearance of cell nuclei
fbk:
Yes - this is definitive evidence of cell death.
ans:
presence of polymorphonuclear leukocytes
fbk:
No - PMNs may appear after necrosis has occurred but may also be present in inflammatory reactions without the presence of necrosis.
ans:
proliferation of fibroblasts
fbk:
No
ans:
swelling of cell cytoplasm
fbk:
No - although this is the first microscopic feature of cell injury, this stage is reversible and may not lead to cell death.
correct_answer:
2
<p>

question:
The type of cell death that is characterized by cell shrinkage, nuclear chromatin condensation and fragmentation of the nucleus and fragmentation of the cell into membrane bound bodies is termed:
ans:
apoptosis
fbk:
Yes - derived from the Greek for falling leaves.  In many cases this occurs as a "natural" programmed event.
ans:
caseous necrosis
fbk:
No
ans:
fat necrosis
fbk:
No
ans:
liquefaction necrosis
fbk:
No
ans:
coagulative necrosis
fbk:
No
correct_answer:
1

<p>
question:
<img align=left src="http://www.uwo.ca/pathol/MedsI/quizzes/fatliver.jpg">
<br clear="all">
Accumulation of lipid within cytoplasm of cells may appear as:
ans:
a vacuole with the nucleus displaced to one side
fbk:
Yes - but, both 1 and 2 are correct.
ans:
fine vacuolization with central nucleus
fbk:
Yes - but, both 1 and 2 are correct.
ans:
neither
mult_ans:
1 2
<p>
question:
Mechanisms that cause fat accumulation in the liver include:
ans:
increased transport of fat to liver
fbk:
Yes - all of these mechanisms can lead to fat accumulation.
ans:
decreased mobilization of fat from liver
fbk:
Yes - all of these mechanisms can lead to fat accumulation.
ans:
decreased utilization of fat by liver cells
fbk:
Yes - all of these mechanisms can lead to fat accumulation.
ans:
increased synthesis of fat by liver cells
fbk:
Yes - all of these mechanisms can lead to fat accumulation.
mult_ans:
1 2 3 4
<p>