The University of Western Ontario has an extensive and reputable history of activity and excellence in Clinical Pharmacology. The increasingly complicated nature of paediatric care along with the increasing use of pharmacology for the control, cure and prevention of illness among children increases the need for specialists in this critical area.

Paediatric Clinical Pharmacology and Toxicology sub-specialties of Paediatrics.
The first focuses on drugs and their effects on infants, children and mothers, including considerations of efficacy, safety and optimal therapy. Toxicology deals with the toxic effects of drugs and environmental agents on children, mothers and the developing fetus.
There are two outpatient clinics, ADR (Adverse Drug Reaction), and FRAME (Fetal Risk Assessment from Maternal Exposure) Both were established in 1989 and are now located at Children's Hospital.

The Team:

• Dr. Michael Rieder, Professor, Clinical Pharmacology
• Dr. Doreen Matsui, Associate Professor, Clinical Pharmacology
• Dr. David Knoppert, Adjunct Professor, Clinical Pharmacy
• Dr. Gidi Koren, Professor, Jointly appointed in Paediatrics and Medicine
• Dr. Jack Bend, Professor, Jointly appointed in Paediatrics and Physiology & Pharmacology
• Dr. Dave Freeman
• Dr. Guido Filler, Professor, Paediatric Nephrology, Clinical Pharmacology

Multi-disciplinary team of paediatric physicians, specially certified nurses, paediatric respiratory therapists, pharmacists, nutritionists, social workers, child life and rehabilitation therapists

• Intensivists are board certified in their primary speciality and have received further training in paediatric intensive care
• Intensivists are academic physicians with multiple roles within the hospital including cutting-edge research, teaching and committee work

The Facts:

• Formed in 1988
• Paediatric Clinical Pharmacology provides 3-4 months of inpatients coverage on the CTU each year
• Two out-patient services (ADR, FRAME)
• In-patient consulting service
• Clinical Pharmacology Laboratory established in 1989
  • Supported by external grants
  • Provides support to the Division of Allergy and Clinical Immunology of the Department of Medicine
  • Goal of expanding basis science research into the area of immunopharmacology and pharmacogenetics and to develop a collaborative research program with other researchers
• Clinical Investigation program with collaborations with other child health care specialists in the area of optimal drug therapy for children

University of Western Ontario, Department of Paediatrics
800 Commissioners Road East, Rm E6-103
London, Ontario, Canada N6A 5W9
Tel: (519) 685-8129  Fax: (519) 685-8156