Welcome to the Singh Lab

The University of Western Ontario
Schulich School of Medicine & Dentistry
Department of Microbiology & Immunology

Recent Publications

1.  Summers KL and Singh B. 2012. Gut microbes and regulatory Th17 cells in Type 1 diabetes. Immunotherapy. 4: 363–364.

2. Bellemore SM; Nikoopour E; Au BC; Krougly O; Lee-Chan E; Haeryfar SM; Singh B. Anti-atherogenic peptide Ep1.B derived from Apolipoprotein E induces tolerogenic plasmacytoid dendritic cells. Clin Exp Immunol; 2014 May (in press); PubMed ID: 24784480

3. Nikoopour E, Singh B. Reciprocity in microbiome and immune system interactions and its implications in disease and health. Inflamm Allergy Drug Targets; 2014 Apr 13; 13(2):94-104. PubMed ID: 24678760

4. Singh B, Nikoopour E, Huszarik K, Elliott JF and Jevnikar AM. 2011. Immunomodulation and Regeneration of Islet Beta cells by Cytokines in Autoimmune Type 1 Diabetes. J Interferon Cytokine Res. 31: 711-719.   

5. Nikoopour E, Sandrock C, Huszarik K, Krougly O, Lee-Chan E, Masteller EL, Bluestone JA and Singh B. 2011. Cutting edge: Vasostatin-1 derived peptide ChgA29-42 is Antigenic Epitope of diabetogenic BDC2.5 T cells in NOD mice. J. Immunol. 186:3831-3835.

6. Huszarik K, Wright B, Keller C, Nikoopour E, Krougly O, Lee-Chan E, Qin HY, Cameron MJ, Gurr WK, Hill DJ, Sherwin RS, Kelvin DJ, Singh B. Adjuvant Immunotherapy Increases {beta} Cell Regenerative Factor Reg 2 in the Pancreas of Diabetic Mice. Journal of Immunology 2010; 185: 5120-5129.

7. Nikoopour E, Schwartz J, Huszarik K, Sandrock C, Krougly O, Lee-Chan E, Singh B. 2010. Th17 polarized cells from Nonobese Diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. Journal of Immunology 2010; 184: 4779-4788.

8. Nikoopour E, Schwartz J, Huszarik K, Sandrock C, Krougly O, Lee-Chan E, Singh B. 2010. Th17 polarized cells from Nonobese Diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. J Immunol 184: 4779-4788.

9. Kilgannon P, Novak Z, Fotedar A, Singh B. 2010. Junctional diversity prevents negative selection of an antigen-specific T cell repertoire. Mol Immunol 47: 1154-1160.

10. French MB, Loeb MB, Richardson C, Singh B. Research preparedness paves the way to respond to pandemic H1N1 2009 influenza virus. Can J Infect Dis Med Microbiol. 20:e63-e66, 2009.

11. Zhang X, Alnaeeli M, Singh B, Teng YT. 2009. Involvement of SOCS3 in regulation of CD11c+ dendritic  cell-derived osteoclastogenesis and severe alveolar bone loss. Infect Immun. 77: 2000-2009.

12. Stephens TA, Nikoopour E, Rider BJ, Leon-Ponte M, Chau TA, Mikolajczak S, Chaturvedi P, Lee-Chan E, Flavell RA, Haeryfar SM, Madrenas J, Singh B. 2008. Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E. J. Immunol. 181: 6859-6871.

13. Enayat Nikoopour, Jordan Ari Schwartz and Bhagirath Singh. 2008. Therapeutic Benefits of Regulating Inflammation in Autoimmunity. Inflammation & Allergy-Drug Targets, 7: 203-210

14. Mukherjee R, Chaturvedi P, E. Lee-Chan E, B. Singh B. 2008. Exogenous CLIP Localizes into endocytic compartment ofcells upon internalization: Implications for antigen presentation by MHC class II molecules. Mol Immunol 45: 2166-2176.

15. Marleau AM, Summers KL, Singh B. 2008. Differential contributions of APC subsets to T cell activation in non-obese diabetic mice. J Immunol. 180: 5235-5249.

16. Bocksch L, Rider BJ, Stephens T, Dai E, Liu L, Diao H, Viswanathan K, Munuswamy-Ramanujam G, Singh B, Lucas A. 2007. C-terminal apolipoprotein E-derived peptide, Ep1.B, displays anti-atherogenic activity. Atherosclerosis. 194: 116-124.

17. Summers KL, Marleau AM, Mahon JL, McManus R, Hramiak I, Singh B. 2006. Reduced IFN-a secretion by blood dendritic cells in human diabetes. Clin Immunol 121:81-89.

18. Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh, B. 2006. A novel mechanism of regulatory T cell-mediated downregulation of autoimmunity.  Int Immunol. 18:1001-15.

19. Mukherjee R, Wagar DA , Stephens TA,  Lee-Chan E, Singh B. 2005. Identification of CD4+ T cell specific epitopes of islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) – a novel β cell autoantigen in type 1 diabetes. J. Immunol. 174: 5306-15.

20. Qin HY, Chaturvedi P, Singh, B. 2004. In vivo apoptosis of diabetogenic T cells in NOD mice by IFN-γ/TNF-α.  Int Immunol. 16:1723-1732.

21. Rajput A, Singh B. 2004 Gene expression profiling in type 1 diabetes prone NOD mice immunized with a disease protective autoantigenic peptide. J. Autoimmun. 23: 311-321.

22. Young HY, Zucker P, Flavell RA, Jevnikar AM, Singh B. 2004. Characterization of the role of Major Histocompatibility Complex in type 1 diabetes recurrence after islet transplantation. Transplantation 78: 509-515.

23. Summers KL, Annette AM, Stephens TA, Mahon JL, Singh B. 2004. Dendritic cells and Immune regulation in the pathogenesis and prevention of Type 1 diabetes. Can. J. Diabetes 28: 20-29.

 

 

 

 

 

 

 

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