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Welcome to the Mele Lab


Dr. Tina Mele MD, PhD FRCSC
Assistant Professor

Siebens-Drake Research Institute:
Office: Rm 220c - Phone: 519-661-2111 ext. 83046
Lab: Rm 220 - Phone: 519-661-2111 ext. 81058
Fax: 519-661-3499

LHSC University Campus
Phone: 519-663-3970
Fax: 519-663-3459

Email: tina.mele@lhsc.on.ca

Welcome to the Mele lab.  We are a small unit interested in the immunological events that occur during sepsis with the driving goal of turning scientific discovery from the lab into treatment options in the clinic.

Sepsis is the leading cause of death in patients admitted to the intensive care unit with over 900 000 people affected annually in the United States. Sepsis occurs as a result of a systemic inflammatory response syndrome due to an infection.  Uncontrolled and excessive pro-inflammatory cytokines released by immune cells during sepsis can lead to hypotension, multiple organ dysfunction and eventually, death.  Mortality from severe sepsis still ranges from 30% to 50% and thus, there is an urgent need to further explore the immune mechanism(s) mediating the host response during sepsis.  The immune responses involved in sepsis are complex and not completely understood.  The prevailing hypothesis is that the catastrophic consequences of sepsis stem from excessive and dysregulated host immune responses as opposed to the direct effect of bacterial toxicity.

Growing evidence suggests that inflammatory cytokine gene polymorphisms, innate immunity gene polymorphisms, and coagulation cascade polymorphisms have an impact on the outcome of sepsis.  However, different studies examining the association of single nucleotide polymorphisms have produced conflicting results.  It is possible that host genetic variation can confer predisposition to or protection from infections; however, the precise impact of these inflammatory and immune genetic polymorphisms warrants further clarification.

The current interest of our lab is to study host genetic variations that modulate sepsis severity.  With this understanding we will be able to optimize treatments for and better predict outcomes of sepsis. 


Recent Publications:

Under construction




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