Infection and Immunity Research Forum
Presented by the Graduate Students
The University of Western Ontario

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2014 IIRF Keynote Speaker:

Ronald N. Germain, M.D., Ph.D.

Chief, Laboratory of Systems Biology
Chief, Lymphocyte Biology Section, LSB

National Institute of Allergy and Infectious Diseases, National Institutes of Health




Research Program (taken from NIH Website):


The Lymphocyte Biology Section (LBS) studies basic aspects of innate and adaptive immune function, with an emphasis on the biochemical mechanisms involved in discrimination between self and foreign peptide-associated MHC molecules by T-cells as well as on T-cell antigen-presenting cell interactions and the subsequent delivery of effector function. Experiments at the biochemical, cell, tissue, and organism levels are used to build a more complete picture of both the operation of and the interface between the adaptive and innate immune systems, including the use of novel microscopic live animal imaging methods. Efforts are also underway to create computer models of immune function, both at the tissue and single cell level, the latter with a focus on T-cell antigen receptor signaling and activation. The aim of this work is to create a detailed understanding of how immune responses to foreign pathogens or self antigens are initiated and unfold, as well as to develop new tools for predicting how the immune system will respond if perturbed, for example, by a candidate vaccine.

Publications: Recent Publications (Pubmed)

Research Lab Website: Germain Lab