Evidence-Based Neurology
CATEGORY: Oncology

In suspected cases of leptomeningeal metastases, cerebrospinal fluid (CSF) cytological analysis detected leptomeningeal tumor in less than 60% of cases with only one CSF analysis. The detection rate increased to less than 85% with the second CSF analysis
Date appraised: April 2007
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Treatment of recurrent glioblastoma multiforme with temozolomide was safe and improved the proportion of patients with progression-free survival at 6 months, as compared to procarbazine
Date appraised: January 2005
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Low quality evidence suggested that combined high-dose methotrexate and radiotherapy was the best treatment for primary CNS lymphoma.
Date appraised: June 2003
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In malignant gliomas, age (> 50 or & 50 years) was the most important prognostic variable for survival.
Date appraised: September 2002
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For acute spinal cord compression due to epidural metastasis extremely weak evidence suggests that decompressive surgery was statistically different from radiotherapy alone with respect to maintained or regained ambulatory status.
Date appraised: March 2000
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In patients with single brain metastases, resection plus radiation increased survival time and reduced tumour recurrence as compared with resection or radiation alone.
Date appraised: June 2000
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In patients with newly diagnosed supratentorial brain tumour without seizures there was no role for anticonvulsant prophylaxis.
Date appraised: May 1999
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