Evidence-Based Neurology
CATEGORY: Movement Disorders
There was Insufficient Evidence
to Support STN-DBS surgery in Early Parkinson's Disease
Date appraised: May 2007 [PDF]
In
an open-labeled trial, piracetam was effective and safe in
reducing myoclonus, both as mono or add-on therapy, in patients
with myoclonus
Date appraised: May 2007
[PDF]
Amantadine was
of unproven benefit in the management of dopamine induced dyskinesias in Parkinson's
disease
Date appraised: January 2006
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There was and association between
coffee consumption and the risk of developing Parkinson's disease
Date appraised: May 2005
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In the treatment
of neurogenic orthostatic hypotension, midodrine increased standing systolic
blood pressure and resulted in a small improvement in symptomatic scores. The
clinical significance of this is uncertain.
Date appraised: May 2005
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Ropinirole was an effective
treatment for restless leg syndrome (RLS), but the magnitude of the effect was
uncertain.
Date appraised: November 2004
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At 3 months post-surgery, bilateral
STN or GPi stimulation improved motor function in patients with advanced Parkinson's
disease in the off medication state
Date appraised: April 2004
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In early Parkinson's disease,
Coenzyme Q10 was safe and well tolerated. There was no significant trend towards
slowing of disease progression.
Date appraised: October 2003
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Excessive somnolence occurs
in & 50% of patients with Parkinson's disease. However, less than 1%
had sleep attacks without warning while driving.
Date appraised: November 2002
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Gabapentin
may be helpful in the treatment of essential tremor.
Date appraised: February 2001
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Ropinirole
(DA) reduced risk of dyskinesia in comparison with L-dopa when
used as initial treatment for Parkinson's Disease.
Date appraised: July 2000
[HTML]
[PDF]
In clinically suspected
CJD, an EEG with periodic sharp waves significantly increases
the probability of CJD. Their absence do not rule out CJD.
Date appraised: December 1999
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