Evidence-Based Neurology
CATEGORY: Headache
Topiramate was an effective prophylactic treatment for reducing migraine frequency
Date appraised: December 2005
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Bed rest was no better than immediate mobilization to prevent post-lumbar puncture headache
Date appraised: January 2004
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Oral contraceptives increased the risk of stroke 2.75-fold (95% CI, 2.24, 3.38). There was no significant increased risk among patients with migraine.
Date appraised: October 2003
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Carbamazepine was effective in the short-term management of trigeminal neuralgia (NNT 2.6 vs. placebo). No drugs have demonstrated superiority in monotherapy. Surgery has not been adequately evaluated
Date appraised: April 2003
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All triptans were effective and well tolerated in the treatment of acute migraine. Compared with 100 mg sumatriptan, 12.5 mg rizatriptan and 80 mg eletriptan were slightly more efficacious, and 12.5 mg almotriptan was similarly efficacious but better tolerated.
Date appraised: April 2003
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Guidelines recommended amitriptyline, divalproex sodium, propranolol/timolol, fluoxetine (racemic) and gabapentin as 1st line drugs for migraine prophylaxis
Date appraised: August 2002
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Antidepressant prophylaxis was efficacious for chronic migraine and tension headaches.
Date appraised: April 2002
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Weak evidence supports treatment of post-dural puncture headache with an epidural blood patch
Date appraised: January 2002
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In cerebral sinus thrombosis, low molecular weight heparin (nadoparin) therapy for 3 weeks followed by 3 months of oral anticoagulation demonstrated a non-significant trend towards benefit over placebo. No clinically significant hemorrhages occurred among those with preexisting hemorrhage.
Date appraised: July 2001
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No valid evidence to support any treatment for idiopathic intracranial hypertension
Date appraised: February 2001
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High dose eletriptan (80mg) was more effective than oral sumatriptan (100mg) in alleviating acute migraine pain and associated symptoms.
Date appraised: January 2001
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In patients with unusually severe headache, how useful is the clinical examination in determining whether an "inflammatory" CSF is present?
Date appraised: November 1998
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