Evidence-Based Neurology
CATEGORY: Demyelinating Disease
Natalizumab
decreased the (short-term) relapse rate and MRI lesions in Relapsing Remitting
MS patients
Date appraised: September 2006
Motor deficit, gait instability
and sphincter dysfunction at onset were associated with faster EDSS progression
in patients with multiple sclerosis
Date appraised: November 2005
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The McDonald's MRI criteria
may be useful for the early diagnosis of MS in patients presenting with a clinically
isolated neurological syndrome
Date appraised: November 2004
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Modafinil was a safe treatment
for MS fatigue, but its efficacy remains to be determined.
Date appraised: August 2004
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Interferons decreased
the risk of exacerbations in Relapsing-Remitting Multiple Sclerosis for
2 years. Differing efficacy between various preparations and administration
protocols is questionable.
Date appraised: March 2003
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Mitoxantrone
12mg/m2 may reduce progression of disability in SP MS. However, clinical
significance is questionable.
Date appraised: January 2003
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Steroid
treatment of optic neuritis accelerated short-term visual recovery but
did not improve long term visual function or reduce the risk of development
of MS
Date appraised: May 2002
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In patients with a first
attack of unifocal or multifocal MS and a positive MRI, early Interferon
delayed the development of a second attack (Clinically Definite MS)
Date appraised: October 2001
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Early interferon
treatment delayed the development of a second neurological event (ie. clinically
definite multiple sclerosis) in patients with one demyelinating neurological
event and MRI lesions indicative of previous clinically silent demyelinating
events.
Date appraised: February 2001
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Weak
evidence suggested that intrathecal Baclofen for intractable spasticity
of spinal origin was effective in reducing spasticity and pain in patients with
MS, but the clinical significance is questionable.
Date appraised: September 1999
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In patients with possible
or probable MS, an MRI interpreted as "definitive MS" rules in
the diagnosis.
Date appraised: August 1998
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