Academic Specialized Treatment
London Health Sciences Centre
University Hospital
339 Windermere Road
London Ontario Canada
N6A 5A5
Phone: (519) 663 - 3236

Myasthenia Gravis
Muscle Disease

Neuromuscular Disease
Peripheral nerve Diseases

EMG and NCS (Electromyography and Nerve Conduction Studies)
Single Fibre Electromyography
Neuromuscular transmission

  Associate Professor of Neurology, University of Western Ontario

Dr. Nicolle received his MD from the University of Western Ontario (UWO) in 1985. He completed a neurology residency at UWO (1990) followed by a Canadian Medical Research Council (MRC) scholarship at the Institute of Molecular Medicine, University of Oxford, U.K, where he received his D. Phil/PhD (1994). His research in Oxford was on the cellular immunology and antigen-specific immunotherapy of myasthenia gravis.

Dr. Nicolle is currently an Associate Professor in the Department of Clinical Neurological Sciences at the University of Western Ontario. He is the Neuromuscular Group leader, director of the Myasthenia Gravis Clinic and also the director of the EMG Laboratory at the London Health Science Centre.

For the last several years he has been an examiner for the Royal College of Physicians and Surgeons of Canada (Neurology), and for the Canadian Society of Clinical Neurophysiologists (CSCN; EMG exam) as well as a member of Medical/Scientific Advisory Board of the Myasthenia Gravis Foundation of America.

The Myasthenia Gravis Clinic

Dr. Nicolle is one of the consulting neurologists in the Neuromuscular Clinic where patients with a wide variety of nerve, neuromuscular junction and muscle problems are assessed. Although involved in the management of patients with neuromuscular diseases in general, his specific interest is in myasthenia gravis (MG) and other disorders of neuromuscular transmission. The MG clinic at LHSC, directed by Dr. Nicolle, actively follows several hundred patients with myasthenia gravis referred from a number of centers in Ontario and across Canada. Dr. Nicolle has extensive experience in the diagnosis and management of MG and is involved in research in this disease.


Dr. Nicolle’s main research interests are in the field of myasthenia gravis. Current projects include clinical trials of therapies in MG, possible mechanisms of intravenous immunoglobulin (IVIg) and other clinical trials on immunosuppressive medications potentially useful for the treatment of MG. Collaborating with investigators in other centers including the University of Oxford, other studies have included those looking at mutations in congenital myasthenic syndromes, and anti-MuSK antibodies in seronegative myasthenia gravis. He is also involved in research in the EMG laboratory, including studies of single fibre EMG, and of the longitudinal changes in entrapment neuropathies.


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