Brian L. Pagenkopf
Professor
B.Sc. University of Minnesota
Ph.D. Montana State University
Postdoc Caltech and ETH
Office: Rm 2020 BGS, Lab Rms 204 ChB and 2008 BGS
Phone (Office): +1 519 661-2111 ext 81430
Phone (Lab): +1 519 661-2111 ext 81589
Total Synthesis, Methodology and Silole-based Materials
Awards:
• Department of Defense New Investigator Award
• NSERC Discovery Accelerator Supplement
Current Research Programs:
The Pagenkopf group is engaged in a variety of reaction discovery, methodology development and natural
products/functional materials synthesis projects. Our long term objectives for new transformations is
to bring them to a sufficient state of maturity that they find use in the standard repertoire of synthetic chemistry.
We use natural products to contextualize representative substrates to ensure synthetic relevancy, and in turn some
of these become targets for total synthesis. We have a multidisciplinary research program with expertise in
cyclopropanes, epoxide reactions, THF synthesis, asymmetric catalysis and siloles.
Selected Publications:
Gram Scale Synthesis of the C(18)-C(34) Fragment of Amphidinolide C. Nicholas A. Morra and Brian L. Pagenkopf, Org. Lett. 2011, 13, 572–575. [link] The
Formal [4+3] Cycloaddition Between Donor-Acceptor Cyclobutanes and
Nitrones. Andrew C. Stevens, Cory Palmer and Brian L. Pagenkopf, Org. Lett. 2011, 13, 1528–1531 Improved Yields and Simplified Purification with a Second Generation
Cobalt Catalyst for the Oxidative Formation of trans-THF Rings. Cory
Palmer, Nicholas A. Morra, Andrew C. Stevens, Barbora Bajtos, Benjamin
P. Machin and Brian L. Pagenkopf, Org. Lett. 2009, 11, 5614—5617.
Total Synthesis of (±)-Quebrachamine via [3+2] Cycloaddition and
Chloroacetamide Photocyclization. Barbora Bajtos and Brian L. Pagenkopf,
Eur. J. Org. Chem. 2009, 1072-1077.
First Total Synthesis and Structural Reassignment of (–)-Aplysiallene. Jian Wang and Brian L. Pagenkopf, Org. Lett. 2007, 9, 3703 - 3706.
