Brian L. Pagenkopf Professor B.Sc. University of Minnesota Ph.D. Montana State University Postdoc Caltech and ETH Office: Rm 2020 BGS, Lab Rms 204 ChB and 2008 BGS Phone (Office): +1 519 661-2111 ext 81430 Phone (Lab): +1 519 661-2111 ext 81589
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Total Synthesis, Methodology and Silole-based Materials
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Awards:
• College of Natural Sciences Teaching Excellence Award
• Department of Defense New Investigator Award
• NSERC Discovery Accelerator Supplement
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Current Research Programs:
The Pagenkopf group is engaged in a variety of reaction discovery, methodology development and natural products/functional materials synthesis projects. Our long term objectives for new transformations is to bring them to a sufficient state of maturity that they find use in the standard repertoire of synthetic chemistry. We use natural products to contextualize representative substrates to ensure synthetic relevancy, and in turn some of these become targets for total synthesis. We have a multidisciplinary research program with expertise in cyclopropanes, epoxide reactions, THF synthesis, asymmetric catalysis and siloles.
Selected Publications:
Improved Yields and Simplified Purification with a Second Generation Cobalt Catalyst for the Oxidative Formation of trans-THF Rings. Cory Palmer, Nicholas A. Morra, Andrew C. Stevens, Barbora Bajtos, Benjamin P. Machin and Brian L. Pagenkopf, Org. Lett. 2009, 11, 5614—5617.
Total Synthesis of (±)-Quebrachamine via [3+2] Cycloaddition and Chloroacetamide Photocyclization. Barbora Bajtos and Brian L. Pagenkopf, Eur. J. Org. Chem. 2009, 1072-1077.
Structural Tuning of Silole Electrogenerated Chemiluminescence. Christina Booker, Xin Wang, Samar Haroun, Jigang Zhou, Michael Jennings, Brian L. Pagenkopf and Zhifeng Ding, Angew.
Chem., Int Ed. 2008, 47, 7731-7735.
First Total Synthesis and Structural Reassignment of (–)-Aplysiallene. Jian Wang and Brian L. Pagenkopf, Org. Lett. 2007, 9, 3703 - 3706.
C-2/C-3 Annulation and C-2 Alkylation of Indoles with 2-Alkoxycyclopropanoate Esters. Barbora Bajtos, Ming Yu, Hongda Zhao and Brian L. Pagenkopf, J. Am. Chem. Soc. 2007, 129, 9631 - 9634.
