ChemistryWestern Science

Lars Konermann

Lars Konermann

Contact Information

Title: Professor
Office & Lab: Rm 2016 BGS
Phone (Office): ext 86313
Phone (Lab): ext 86667
E-mail: konerman@uwo.ca
Research Group

Research Areas

Protein Mass Spectrometry. Biophysical and Bioanalytical Chemistry

Traditional Research Division:
Physical & Analytical

Education

Ph.D. (Max Planck Institute, Univ. of Düsseldorf, Germany)


Awards

Research

Our group is interested in exploring the folding mechanisms of proteins, their conformational dynamics, and their interactions with other molecules. We specialize in the development and application of novel electrospray mass spectrometry (ESI-MS) techniques for this purpose. This research bridges the areas of biophysics, biochemistry, and analytical chemistry.

The question how and why a highly disordered protein chain can spontaneously refold into its native structure remains one of the major unsolved problems in biophysical chemistry. Research in this area is of fundamental importance for understanding the factors responsible for protein folding-related diseases such as Alzheimer's and BSE.

Mass spectrometry in conjunction with rapid mixing techniques allows the detection and characterization of short-lived intermediates, thereby providing important insights into the mechanisms by which proteins fold and assemble into quaternary structures. The information from these experiments is complementary to that obtained by optical and NMR spectroscopy.

Other research directions pursued in our laboratory include studies on protein-ligand binding and enzymatic reaction mechanisms.

My Research Group Homepage

Teaching

Publications