ChemistryWestern Science

Lars Konermann

Lars Konermann

Contact Information

Title: Professor
Office & Lab: Rm 2016 BGS
Phone (Office): ext 86313
Phone (Lab): ext 86667
E-mail: konerman@uwo.ca
Research Group

Physical & Analytical Teaching Division

Chemical Biology and Biomaterials

Protein Mass Spectrometry. Biophysical and Bioanalytical Chemistry

Group Website

Education

Ph.D. (Max Planck Institute, Univ. of Düsseldorf, Germany)

Awards

Research

Our group explores the folding mechanisms of proteins, their conformational dynamics, and their interactions with drugs and other molecules. We specialize in the development of novel electrospray mass spectrometry (ESI-MS) and ion mobility spectrometry (IMS) techniques. In addition, we employ state-of-the-art molecular dynamics (MD) simulations. This research bridges the areas of biophysics, biochemistry, and analytical chemistry.

Our research sheds light on the question why highly disordered protein chains can spontaneously fold into their native structures. This question remains one of the major unsolved problems in biophysical chemistry. Advances in this area are of fundamental importance for understanding the factors responsible for protein folding-related diseases such as Alzheimer's and BSE.

Other research directions pursued in our laboratory include studies on molecular motors, enzymatic reaction mechanisms, fundamental aspects of the ESI process, and the relationship between protein structure in solution and in the gas phase.

My Research Group Homepage

Teaching

Selected Publications