Confocal fluorescence microscopy image
Research Highlight: Confocal fluorescence microscopy image of a human coronary artery smooth muscle cell growing on a poly(ester amide) surface. Clicking on the above image will link you to the full details of this work (DOI: 10.1021/bm200149k).

Biopolymers & Biomaterials

Robert Hudson
ChB 226
519 661-2111 ext 86349
Research home page
peptides, oligonucleotides, MRI, fluorescence, imaging

Prof. Hudson is an expert in oligonucleotide, peptide and cyclen chemistries and produce novel biomaterials for imaging purposes.

Elizabeth Gillies
MSA 3202
519 661-2111 ext 80223
Research home page
synthesis of biomaterials; nanomaterials; biodegradable polymers; dendrimers; drug delivery; imaging contrast agents; self-assembly

Prof. Gillies’ research involves the design, synthesis and application of functional molecules. The molecules of interest can range from well-defined oligomers and dendrimers to higher molecular weight polymers. In particular, the group is interested in the interactions of these molecules and their supramolecular assemblies with biological systems to serve as new biomaterials and therapeutics. For example, polymer assemblies may be used as nanocontainers to control the localization within the body of therapeutics ranging from small molecules to proteins and DNA. They may also serve as new scaffolds to display biological ligands, thereby providing new therapeutics or materials for tissue engineering. We are also investigating polymers that degrade by novel mechanisms in response to biological stimuli in order to achieve an unprecendented level of control over the polymer degradation process. Research is also underway to develop new contrast agents for medical imaging.

Douglas W Hamilton
519 661-2111 ext 81594
Research home page
Titanium alloys, electrospun scaffolds, natural polymers, connective tissues, material surface functionalization

Dr. Hamilton's philosophy on biomaterials development is to use biological data from in vitro and in vivo models to re-design materials to further promote desired cell behaviour, and advantageous gene and protein expression. Through characterization of the material chemistry and topography, as well as the cellular response, materials can be furthered adapted where applicable, through the incorporation of biologically active molecules on the surfaces. They are developing a rigorous screening system for gene and protein changes in newly implanted, as well as end stage failure biomaterials.

Lars Konermann
B&GS 2016
519 661-2111 ext 86313
Research home page
Protein Structure and Dynamics, Protein Folding, Protein Aggregation, Protein Folding Diseases, Biological Mass Spectrometry

Research in the Konermann laboratory revolves around conformational studies on proteins. In particular, this work focuses on the mechanisms of biomolecular self-assembly (folding and misfolding of protein chains, as well as the formation of protein-protein contacts). Another aspect of Konermann's research program is the relationship between protein structure, function, and conformational dynamics. Much of this work is based on the application of modern mass spectrometry techniques, in conjunction with isotope exchange and covalent labeling approaches.

Takashi Kuboki
CMLP 1306
519 661-2111 ext. 88519
Research home page
polymer composites; biocomposites; nanocomposites; biopolymers; plastic foaming

Prof. Kuboki’s primary research interests are in the areas of process-structure-property relationships of materials, and development of novel functional materials. The materials include synthetic and natural fiber reinforced polymer composites, biocomposites; nanocomposites, polymer blends, biopolymers, and plastic foams.

Argyrios (Gerry) Margaritis
TEB 377
519 661-2146
Research home page
corrbiopolymer nanoparticles for drug delivery

Prof. Margaritis colaborates with Dr.Jim Koropatnick at the London Regional Cancer Program at Victoria Hospital, using biopolymer nanoparticles loaded with the cancer drug Doxorubicin to kill cancer cells. He also has strong coolaborations with Dr.A.Xenocostas (Hematology Department, Victoria Hospital) for the controlled release of Erythropeitin using biopolymer nanoparticles.

Kibret Mequanint
TEB 439
519 661-2111 ext 88573
Research home page
vascular tissue engineering; biomaterials; scaffold fabrications; cell-material interaction; polyurethanes; bioreactor; extracellular matrix proteins, mass transfer

Tim Newson
SEB 3084
519 850-2973
Research home page:
Ocular biomechanics; ocular drug delivery; imaging contrast agents; constitutive modelling of biomaterials; artificial cornea, ocular tissue mimics.

Prof. Newson’s research involves the use of structural engineering analysis, contaminant transport theories and computational flow dynamics to improve the understanding of the biomechanical, viscoelasticity and fluid flow behaviour of the eye. This has included studies of the cornea, sclera, posterior chamber, optic nerve and extraocular muscles. Further work has been instigated recently investigating drug transport and CT imaging of the eye, ocular needle mechanics for intravitreal treatments, the use of elastic wave theories to determine in vivo corneal elastic properties and the development of artificial analogues for ocular tissues and vitreous humour using PVA-cryogels.

Peter Rogan
DSB 5012
519 661-2111 ext 84355
Research home page
nanoscale analysis of DNA structure, correlated confocal and atomic force microscopy 

Structural analysis of short DNA probes bound to metaphase chromosomes by nanoscale imaging reveals the topological context of these DNA sequences in the genome. Recent studies have investigated the coupling of  kinetochore structural dynamics and centromeric DNA segregation.  The methods developed by Dr. Rogan are being used to investigate the topological context of low- and single copy probe sequences on chromosomes, with the goal of understanding and mitigating differences in their accessibility to targets on different homologs.

Jin Zhang
TEB 465
519 661-2111 ext 88322
Research home page:
Nanocomposites; surface and interface of hybrid materials; protein conjugation

Dr. Zhang’s research activities focus on: (1) development of new chemical and physical processes for advanced nanocomposites with enhanced optical, magnetic, mechanical properties; (2) design and synthesis of the interface between nanostructures and biopolymer/biomolecules; (3) investigation of the correlation between nanostructures and biological systems.

News and Events

Congratulations to the 2016 AMBI Undergraduate Research Award recipients:

Yi Min Liang working with Dr. John Corrigan (Chemistry) and Dr. Giovanni Fanchini (Physics and Astronomy)

Keifer Stevenson working with Dr. Zhifeng Ding (Chemistry) and Dr. Jun Yang (Mech and Mater Engineering)

Anastasiya Vinokurtseva working with Dr. Robert Hudson (Chemistry) and Dr. Robert Bartha (Medical Biophysics)

Information on the program can be found by clicking -->here<--.


Dr. John F. Corrigan

Department of Chemistry
Western University
London, ON
N6A 5B7 Canada
(519) 661 2111 x86387

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Also of interest:

Research, Education and Innovation in Materials and Biomaterials