Brenda Murphy, PhD
Clinical Human Cytogenetics & Molecular Genetics
Biological & Geological Sciences 3034
(519) 661-2111 x 86501
My research interest lies in the cytogenetic, molecular genetic and biochemical genetic diagnosis of human genetic diseases. I am especially interested in genotype/epigenotype-phenotype correlations for clinical diagnostic purposes. At the beginning of my genetic career I worked at the local hospital in both the Cytogenetic and the Molecular Diagnositic laboratories for ~15 years. When I moved to Western I expanded upon this knowledge by studying genetically identical twins discordant for disorders that are genetically more complex and have an interaction with environmental factors. In addition, I am interested in chimpanzee comparative genomics, schizophrenia, cancer (breast cancer, colon cancer and leukemia), epigenomics, imprinting, pharmacogenomics, immunogenomics, human development, teratogens, prenatal diagnosis, nurigenomics, genome structure (telomeres, subtelomeres, centromeres, low copy repeats, copy number variation, chromosome breakpoints, unbalanced chromosome rearrangements), microarray meta-analysis, comparative genomic hybridizaton assays , next generation sequencing techniques and bioinformatics.
Degrees and Institutions
- CCMG Cytogenetic Postdoctoral Fellowship Training at McMaster University in Hamilton, Ontario
- CCMG Molecular Genetic Postdoctoral Fellowship training at McMaster University in Hamilton, Ontario and Credit Valley Hospital in Mississauga, Ontario Canada
- PhD Biology from The University of Western Ontario in London, Ontario, Canada
- Human Molecular Genetics Diploma from the Michener Institute of Applied Health Science in Toronto, Ontario Canada
- Human Cytogenetics Diploma from the Micherner Institute of Applied Health Science in Toronto, Ontario Canada
- BSc Biology from The University of Western Ontario in London, Ontario Canada
- Biology 1202B: General Biology
- Biology 3592A: Principles in Human Genetics
- Biology 3595A: Advanced Genetics
- Biology 3596A: Genome and Beyond: A Laboratory Course
- Biology 4560B: Human Molecular Genetics
- Murphy BC, O’Reilly RL and Singh SM. DNA methylation and mRNA expression of SYN IIIa, a candidate gene for schizophrenia. BMC Medical Genetics (2008) 9:115.
- Murphy BC, Scriver C R and Singh SM. CpG methylation accounts for a recurrent mutation (c.1222C>T) in the human PAH gene. Human Mutat (2006) 27:975.
- Murphy BC, O’Reilly R and Singh SM. Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia. AJMG Part B (Neuropsyc Gen) (2005) 133B:37-42.
- Singh SM, McDonald P, Murphy BC and O’Reilly R. Incidental neurodevelopmental episodes in the etiology of schizophrenia: an expanded developmental model. Clin Genet (2004) 65:435-440.
- Singh SM, Murphy BC and O’Reilly R. Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia. Clin Genet (2003) 64:451-460.