Western University BiologyWestern Science

Robert Cumming, PhD

Redox Proteomics and Cell Biology


Robert Cumming Position:
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Associate Professor
Biological & Geological Sciences 3078
Biological & Geological Sciences 3082
office: (519) 661-2111 x 81578
lab: (519) 661-2111 x 81579 
519 661-3935
rcummin5@uwo.ca

Metabolic and Redox Regulation of Neurodegenerative Diseases and Aging

The Cumming lab focuses on mechanisms of aging and neurodegeneration.  We are currently examining the role of aerobic glycolysis in regulating memory and susceptibility to neurotoxins in cell culture and mouse models of Alzheimer’s disease.  We also study redox regulation of the antioxidant response in cell culture models of Huntington’s disease.  In addition, we are determining the effect of expression of p66shc, a gene that regulates the level of reactive oxygen species (ROS) and lifespan in mammals, on redox processes linked to cytoskeletal remodeling.  Metabolic reprogramming and regulation of ROS levels are now emerging as major determinates of aging and disease processes.

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