Dr. Singh's Links:
- Dr. Singh's Home Page
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- Projects:
Alcoholism Bioinformatics Epigenetics Fetal Alcohol Syndrome Schizophrenia - Publications
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Relevant Links:
Relevant Links:
Dr. Shiva Singh
Molecular Genetics of Complex Diseases and Phenotype
Publications
- Kleiber ML, Singh SM. (January 2009)Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain. Genomics, (Epub)
- Singh SM, Castellani CA, O'Reilly RL. (January 2009)Copy number variation showers in schizophrenia: an emerging hypothesis. Mol. Psychiatry, (Epub)
- Singh SM, O'Reilly, R. (January 2009)(Epi)genomics and neurodevelopment in schizophrenia: monozygotic twins discordant for schizophrenia augment the search for disease-related (epi)genomic alterations. Genome, 52(1):8-19.
- Weng J, Symons MN, Singh SM. (December 2008)Studies on Syntaxin 12 and Alcohol Preference Involving C57BL/6J and DBA/2J Strains of Mice. Behav. Genet., (Epub)
- Murphy BC, O'Reilly RL, Singh SM. (December 2008)DNA methylation and mRNA expression of SYNIII, a candidate gene for schizophrenia. BMC Med. Genet., 9(1):115.
- Zou SB, Weng J, Symons MN, Singh SM. (November 2008) Role of Potassium Channel Gene Kcnj10 in Ethanol Preference in C57bl/6J and DBA/2J Mice. Alcohol Clin. Exp. Res., (Epub)
- Sheikh HI, Hayden EP, Singh SM, Dougherty LR, Olino TM, Durbin CE, Klein DN. (2008) An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood. Pers. Individ. Dif., 45(5):425-28.
- Singh SM, Treadwell J, Kleiber ML, Harrison M, Uddin RK. (October 2007) Analysis of behaviour using genetical genomics in mice as a model: from alcohol preferences to gene expression differences. Genome, 50(10):877-97.
- Murphy BC, Scriver C, Singh SM. (September 2006) CpG methylation accounts for a recurrent mutation (c1222 C->T) in human PAH gene. Hum. Mutat., 27(9):975.
- Wang Y, Hale L, Hill KH, Singh SM. (2006) Mining invariants in biological sequences. Data Mining in Life Sciences - Workshops 2006:111-118.
- Uddin RK, Singh SM. (May 2006) Ethanol-responsive genes: identification of transcription factors and their role in metabolomics. Pharmacogenomics J., 2007 Feb;7(1):38-47.
- Uddin RK, Singh SM. (April 2006) cis-Regulatory sequences of the genes involved in apoptosis, cell growth, and proliferation may provide a target for some of the effects of acute ethanol exposure. Brain Res., May 9;1088(1):31-44.
- Uddin RK, Zhang Y, Siu VM, Fan YS, O'Reilly RL, Rao J, Singh SM. (March 2006) Breakpoint Associated with a novel 2.3 Mb deletion in the VCFS region of 22q11 and the role of Alu (SINE) in recurring microdeletions. BMC Med. Genet., 7: 18.
- Loney KD, Uddin RK, Singh SM. (January 2006) Analysis of metallothionein brain gene expression in relation to ethanol preference in mice using cosegregation and gene knockouts. Alcohol Clin. Exp. Res., 30: 15-25.
- Uddin RK, Treadwell JA, Singh SM. (September 2005) Towards unraveling ethanol-specific neuro-metabolomics based on ethanol responsive genes in vivo. Neurochem. Res., 30: 1179-90.
- Murphy BC, O'Reilly RL, Singh SM. (February 2005) Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 133: 37-42.
- Singh SM, McDonald P, Murphy B, O'Reilly R. (June 2004) Incidental neurodevelopmental episodes in the etiology of schizophrenia: an expanded model involving epigenetics and development. Clin. Genet., 65: 435-40.
- Treadwell JA, Pagniello KB, Singh SM (June 2004) Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice. Behav. Genet., Jul;34(4):425-39.
- Treadwell JA, Singh SM. (February 2004) Microarray analysis of mouse brain gene expression following acute ethanol treatment. Neurochem. Res., 29: 357-69.
- Singh SM, Murphy B, O'Reilly RL. (December 2003) Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia. Clin. Genet., 64: 451-60.
- Loney KD, Uddin KR, Singh SM. (March 2003) Strain-specific brain metallothionein II (MT-II) gene expression, its ethanol responsiveness, and association with ethanol preference in mice. Alcohol Clin. Exp. Res., 27: 388-95.
- McDonald P, Lewis M, Murphy B, O'Reilly R, Singh SM. (February 2003) Appraisal of genetic and epigenetic congruity of a monozygotic twin pair discordant for schizophrenia. J. Med. Genet., 40: E16.
- Murphy BC, Chiu T, Harrison M, Uddin RK, Singh SM. (December 2002) Examination of ethanol responsive liver and brain specific gene expression, in the mouse strains with variable ethanol preferences, using cDNA expression arrays. Biochem. Genet., 40: 395-410.
- Harrison M, Singh SM. (December 2002) Genetics and differential expression of NADH:ubiquinone oxidoreductase B8 subunit in brains of genetic strains of mice differing in voluntary alcohol consumption. Biochem. Biophys. Acta., 1579: 164-72.
- Singh SM, Murphy B, O'Reilly R. (November 2002) Monozygotic twins with chromosome 22q11 deletion and discordant phenotypes: updates with an epigenetic hypothesis. J. Med. Genet., 39: e71.
- Singh SM, Murphy B, O'Reilly R. (August 2002) Epigenetic contributors to the discordance of monozygotic twins. Clin. Genet., 62: 97-103.
- Deb-Rinker P, O'Reilly RL, Torrey EF, Singh SM. (April 2002) Molecular characterization of a 2.7-kb, 12q13-specific, retroviral-related sequence isolated by RDA from monozygotic twin pairs discordant for schizophrenia. Genome., 45: 381-90.
- Song X, Singh SM. (June 2001) Distribution and molecular characterization of mRNA-binding proteins specific to the (U)15 region of 3' UTR of the mouse catalase (Cas-1). DNA Cell Biol., 20: 339-48.
- Black KA, Singh SM. (2001) Conditional Lethal Mutations as Experimental Tools. Encyclopedia of Life Sciences:1-5
- George CF, Singh SM. (January 2000) Hypocretin (orexin) pathway to sleep. Lancet., 355: 6.
- Deb-Rinker P, Klempan TA, O'Reilly RL, Torrey EF, Singh SM. (October 1999) Molecular characterization of a MSRV-like sequence identified by RDA from monozygotic twin pairs discordant for schizophrenia. Genomics., 61: 133-44.
- Mancini DN, Singh SM, Archer TK, Rodenhiser DI. (July 1999) Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors. Oncogene., 18: 4108-19
- Deb P, Klempan TA, O'Reilly RL, Singh SM. (February 1999) Search for retroviral related DNA polymorphisms using RAPD PCR in schizophrenia. Biochim. Biophys. Acta., 1453: 216-20.
- Mancini DN, Rodenhiser DI, Ainsworth PJ, O'Malley FP, Singh SM, Xing W, Archer TK. (March 1998) CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site. Oncogene., 16: 1161-9.
- Mancini D, Singh S, Ainsworth P, Rodenhiser D. (July 1997) Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1). Am. J. Hum. Genet., 61: 80-7.
- Hill KA, Singh SM. (June 1997) The evolution of species-type specificity in the global DNA sequence organization of mitochondrial genomes. Genome., 40: 342-56.
- Rodenhiser DI, Andrews JD, Mancini DN, Jung JH, Singh SM. (February 1997) Homonucleotide tracts, short repeats and CpG/CpNpG motifs are frequent sites for heterogeneous mutations in the neurofibromatosis type 1 (NF1) tumour-suppressor gene. Mutat. Res., 373: 185-95.
- Rodenhiser DI, Jung JH, Gillett JM, Hovland K, Andrews J, Ainsworth PJ, Coulter-Mackie M, Singh SM. (1997) A five-basepair deletion (7118 delTTTTA) identified within neurofibromatosis (NF1) exon 39. Hum. Mutat. 9: 473.
- Singh SM, George CF, Ott RN, Rattazzi C, Guilleminault C, Dement WC, Mignot E. (July 1996) IgH (mu-switch and gamma-1) region restriction fragment length polymorphism in human narcolepsy. J. Clin. Immunol., 16: 208-15.
- Tagliabracci CE, Singh SM. (June 1996) Genetic regulation of gene-specific mRNA by ethanol in vivo and its possible role in ethanol preference in a cross with RI lines in mice. Biochem. Genet., 34: 219-38.
- Andrews JD, Mancini DN, Singh SM, Rodenhiser DI. (April 1996) Site and sequence specific DNA methylation in the neurofibromatosis (NF1) gene includes C5839T: the site of the recurrent substitution mutation in exon 31. Hum. Mol. Genet., 5: 503-7.
- Rodenhiser D, Chakraborty P, Andrews J, Ainsworth P, Mancini D, Lopes E, Singh S. (June 1996) Heterogenous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs. Oncogene., Jun 20;12(12):2623-9.
- Reimer, DL, Singh, SM. (april 1996) Distinct mRNA-binding proteins interacting with short repeat sequences of the 3' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene, Cas-1. DNA Cell Biol., 15: 317-28.
- O'Reilly RL, Singh SM. (February 1996) Retroviruses and schizophrenia revisited. Am. J. Med. Genet., 67: 19-24.
- Singh SM, Rodenhiser DI, Ott RN, Jung JH, Ainsworth PJ. (1996) Strategies and applications of DNA level diagnosis in genetic diseases: past experiences and future directions. Biotechnol. Annu. Rev., 2: 409-46.
- Reimer DL, Bailley J, Singh SM. (May 1994) Complete cDNA and 5' genomic sequences and multilevel regulation of the mouse catalase gene. Genomics., 21: 325-36.
- O'Reilly RL, Bogue L, Singh SM. (1994) Pharmacogenetic response to antidepressants in a multicase family with affective disorder. Biol. Psychiatry., 36: 467-71.
- Rodenhiser DI, Ainsworth PJ, Coulter-Mackie MB, Singh SM, Jung JH. (May 1993) A genetic study of neurofibromatosis type 1 (NF1) in south-western Ontario. II. A PCR based approach to molecular and prenatal diagnosis using linkage. J. Med. Genet., 30: 363-8.
- Rodenhiser DI, Coulter-Mackie MB, Singh SM. (April 1993) Evidence of DNA methylation in the neurofibromatosis type 1 (NF1) gene region of 17q11.2. Hum. Mol. Genet., 2: 439-44.
- Ainsworth PJ, Rodenhiser DI, Costa MT. (March 1993) Identification and characterization of sporadic and inherited mutations in exon 31 of the neurofibromatosis (NF1) gene. Hum. Genet., March;91(2):151-6.
- Hill KA, Schisler NJ, Singh SM. (September 1992) Chaos game representation of coding regions of human globin genes and alcohol dehydrogenase genes of phylogenetically divergent species. J. Mol. Evol., 35: 261-9.
- Ditta SD, George CF, Singh SM. (February 1992) HLA-D-region genomic DNA restriction fragments in DRw15 (DR2) familial narcolepsy. Sleep., 15: 48-57.
- Rodenhiser DI, Coulter-Mackie MB, Jung JH, Singh SM. (November 1991) A genetic study of neurofibromatosis 1 in south-western Ontario. I. Population, familial segregation of phenotype, and molecular linkage. J. Med. Genet., 28: 746-51.
- George CF, Singh SM. (June 1991) Juvenile onset narcolepsy in an individual with Turner syndrome. A case report. Sleep., 14: 267-9.
- Bond SL, Wigle MR, Singh SM (March 1991) Acetaldehyde dehydrogenase (Ahd-2)-associated DNA polymorphisms in mouse strains with variable ethanol preferences. Alcohol Clin. Exp.Res., Mar;15(2):304-7.
- Elliott J, Coulter-Mackie MB, Jung JH, Rodenhiser DI, Singh SM. (April 1991) A method for transforming lymphocytes from very small blood volumes suitable for paediatric samples. Hum Genet., 86: 615-6.
- Schisler NJ, Singh SM. (February 1991) A quantitative genetic analysis of tissue-specific catalase activity in Mus musculus. Biochem. Genet., 29: 65-89.
- el-Hage S, Singh SM. (October 1990) A 5-fold reduction in sister-chromatid exchange following implantation of mouse embryos is not directly related to the expression of embryonic genes responsible for oxygen radical metabolism. Mutat. Res., 232: 217-26.
- Singh SM, George CF, Kryger MH, Jung JH. (March 1990) Genetic heterogeneity in narcolepsy. Lancet., 335: 726-7.
- Reimer DL, Singh SM. (1990) In situ hybridization studies on murine catalase mRNA expression during embryonic development. Dev. Genet., 11: 318-25.
- el-Hage S, Singh SM. (1990) Temporal expression of genes encoding free radical-metabolizing enzymes is associated with higher mRNA levels during in utero development in mice. Dev. Genet., 11: 149-59.
- Bond SL, Singh SM. (1990) Studies with cDNA probes on the in vivo effect of ethanol on expression of the genes of alcohol metabolism. Alcohol., 25: 385-94.
- Wei VL, Singh SM. (1988) Genetically determined response of hepatic aldehyde dehydrogenase activity to ethanol exposures may be associated with alcohol sensitivity in mouse genotypes. Alcohol Clin. Exp. Res., 12: 39-45.
- Schisler NJ, Singh SM. (1987) Inheritance and expression of tissue-specific catalase activity during development and aging in mice. Genome., 29: 748-60.
- Singh SM, Reimer DL. (1984) Distribution of sister chromatid exchanges on the mouse chromosomes in vivo with reference to the replication properties of the X chromosome. Can. J. Genet. Cytol., 26: 152-7.
- Reimer DL, Singh SM. (1983) Cyclophosphamide-induced in vivo sister chromatid exchanges (SCE) in Mus musculus. III. Quantitative genetic analysis. Genetics., 1983 Sep;105(1):169-79.
- Reimer DL, Singh SM. (1983) Cyclophosphamide-induced in vivo sister chromatid exchange in Mus Musculus. II: Effect of age and genotype on sister chromatid exchange, micronuclei and metaphase index. Mech. Ageing Dev., 1983 Jan;21(1):59-68.
- Reimer DL, Singh SM. (1982) Cyclophosphamide induced in vivo sister chromatid exchanges (SCE) in Mus musculus. I: Strain differences and empirical association with relative chromosome size. Can. J. Genet. Cytol., 1982;24(5):521-8.
- Reimer D, Singh SM. (1981) A kindred with 5 cases of multiple endocrine adenomatosis type I. Hum. Hered., 1981;31(2):84-8.
