Disulfide-linked protein aggregates (green) in both the cytosol and nuclei (blue) of mouse hippocampal neurons
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Large disulfide-linked protein aggregates (orange) are processed independently of lysosomes (green) in nerve cells. [photo: Robert Cumming] Dr. Robert C. Cumming
Redox Proteomics and Cell Biology
Publications
Journal Articles
- Pitts A, Dailey K, Newington JT, Chien A, Arseneault R, Cann T, Thompson LM and Cumming RC. Dithiol-based compounds maintain the expression of the antioxidant protein Peroxiredoxin 1 which counteracts the toxicity of mutant Huntingtin. J Biol Chem. 287(27), 22717-22729 (2012)
- Newington JT, Pitts A, Chien A, Arseneault R, Schubert D and Cumming RC. Amyloid beta resistance in nerve cells is mediated by the Warburg effect. PLoS One. 6(4):e19191 (2011)
- Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A and Finley KD. p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects. Autophagy 7(6), (2011).
- Schubert D., Herrera F., Cumming R., Read J., Low W., Maher P. and Fischer WH. Neural cells secrete a unique repertoire of proteins. J Neurochem. 109(2):427-35 (2009).
- Simonsen A.*, Cumming R.C.*, Brech A., Isakson P., Schubert D. and Finley K.D. Enhanced Neuronal Autophagy Promotes Longevity and Oxidant Resistance in Drosophila. Autophagy 4(2):176-84 (2008). * equal contribution
- Cumming R.C. , Dargusch R., Fischer W.H. and Schubert D. Increase in expression and resistance to sulfhydryl oxidation of peroxiredoxin isoforms in Amyloid-beta-resistant nerve cells. J Biol Chem. 282 (42), 30523- 30534 ( 2007).
- Simonsen A., Cumming R.C. and Finley K.D. Linking Lysosomal Trafficking Defects with Changes in Aging and Stress Response in Drosophila, Autophagy. 3(5), 499-501 (2007).
- Simonsen A., Cumming R.C., Lindmo K., Galaviz V., Cheng S., Rusten T.E., Finley K.D . Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles. Genetics. 176 (2), 1283-1297 (2007).
- Cumming R.C. and Schubert D. Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer’s disease. F ASEB J. 19 (14), 2060-2062 (2005).
- Cumming R.C. , Andon N.L., Haynes P.A., Park M., Fischer W.H., Schubert D.Protein disulfide bond formation in the cytoplasm during oxidative stress. J Biol Chem. 279 (21), 21749-21758 (2004)
- Soucek T., Cumming R., Dargusch R., Maher P and Schubert D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39 (1), 43-56 (2003)
- Finley K.D., Edeen P.T., Cumming R.C., Mardahl-Dumesnill M.D., Taylor B.J., Benedetti M. and McKeown M. blue cheese Mutations Define a Novel, Conserved Gene Involved in Progressive Neural Degeneration. J of Neuroscience. 23(4), 1254-1264 (2003)
- Cumming R.C. , Lightfoot J., Beard K., Youssoufian H., O’Brien P.J. and Buchwald M. Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nature Medicine 7(7), 814-820 (2001)
Book Chapters
- Cumming R.C. Analysis of global and specific changes in the disulfide proteome using Redox 2D-PAGE. In Methods in Molecular Biology: Redox Mediated Signal Transduction . Ed. Hancock J.T. Human Press Inc. (2008)
- Cumming R.C ., Simonsen A. and Finley K.D. Quantitative analysis of autophagic activity in Drosophila neural tissues by measuring the turnover rates of pathway substrates. Methods in Enzymology, Vol. 447, Chapter 35 (2008)
